Mycoplasma pneumoniae and other pathogens in the aetiology of lower respiratory tract infections among Japanese children

Sakurai, Nobukiyo; Nagayama, Yoko; Honda, Akihito; Makuta, Masahiro; Yamamoto, Koshi; Kojima, Satoshi

doi:10.1016/s0163-4453(88)97604-9

Cited by 18 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2); the presence of specific antibodies in some of the young children agrees with the study of Sakurai et al, 21 who isolated M. pneumoniae with high frequency in children with respiratory disease up to the age of 3 years, suggesting that the pathological role of this organism may be more important in the 3-6 years agegroup than previously suspected. We tried to evaluate whether antibodies to any of the polypeptides would enable distinction between primary infections and re-infections (table 11).…”

supporting

confidence: 89%

Immunoblotting patterns with Mycoplasma pneumoniae of serum specimens from infected and non-infected subjects

Aubert¹,

Pozzetto²,

Hafid³

et al. 1992

Journal of Medical Microbiology

View full text Add to dashboard Cite

Summary. Two hundred and ninety-four serum specimens from 248 subjects, whose complement fixation (CF) titres to Mycoplasma pneumoniae were known, were further investigated by IgG immunoblotting. After analysis of M . pneumoniae proteins by SDS-PAGE, nine polypeptides (p) with mol. wts of 180-43 Kda were selected for immunoblotting studies. Antibodies to M. pneumoniae measured by immunoblotting appeared progressively with age; most subjects more than 19 years old gave positive results. For most of the polypeptides, there was an increase in the frequency of band detection when the CF titres were higher. Furthermore, paired serum specimens from 10 patients with M. pneumoniae infection, as demonstrated by a rise in CF antibody titre, were tested for IgG blotting patterns. Generally, p180 (the P1 adhesin of M. pneumoniae), p172 and p84 were shown to be the dominant targets of the immune response to this organism and may have diagnostic value.

show abstract

supporting

confidence: 89%

Immunoblotting patterns with Mycoplasma pneumoniae of serum specimens from infected and non-infected subjects

Aubert¹,

Pozzetto²,

Hafid³

et al. 1992

Journal of Medical Microbiology

View full text Add to dashboard Cite

show abstract

“…In the two townships studied the attack rates were significantly higher in children under five than among children from five to fourteen years old. Such data contrasts with results published by various authors who point out that first infection in early infancy is usually asymptomatic and that the most affected group is that between five and nine years [1,7,10,[12][13][14]. However, Nagayama et al [15], after studying the cases diagnosed in the pediatric practice of a general hospital in Japan, show that infection occurs very frequently in small children, four being the age with the greatest number of cases registered.…”

Section: Discussionmentioning

confidence: 76%

Community outbreak of acute respiratory infection by Mycoplasma pneumoniae

Domı́nguez

Minguell²,

Torres³

et al. 1996

Eur J Epidemiol

View full text Add to dashboard Cite

We present the results of the investigation of an epidemic outbreak of Mycoplasma pneumoniae infection which affected 95 schoolchildren from certain village in Catalonia. The investigation took an epidemiological, clinical and microbiological approach, detecting by capture enzyme-immunoassay technique the presence of IgM antibodies against M. pneumoniae. All cases occurred over a 9 week period. The attack rate in children under five was 18% and 8.2% in those from 5-14 years. The age mean and standard deviation of the cases was 5.2 +/- 3.5 years, the range being from 9 months to 14 years. Cough was the most common clinical manifestation (87.4%), followed by fever (67.4%), asthenia (21.1%), abdominal pain (18.9%), vomiting (13.7%), earache (8.4%) and sore throat (6.3%). There was no significant difference in the distribution of symptoms according to age groups. IgM anti M. pneumoniae was positive in 36 (37.9%) of the samples analysed. Treatment chosen in most cases (90) was eritromicin and there was a correct evolution in all cases except for two clinical and radiological recurrences. Hospitalization was only necessary in 5 cases. The present findings are important to emphasize the high incidence of M. pneumoniae respiratory disease in children under 5, and suggests that with respiratory processes affecting very young children, a possible Mycoplasma pneumoniae infection should also be considered and the necessary action taken in the form of early and appropriate treatment.

show abstract

“…This compares with only 7% during the UK epidemic of 1970-1972 [9], A study from Japan [10] also suggested that M. pneumoniae may be a more important pathogen than previously recognised in younger children.…”

Section: Discussionmentioning

confidence: 83%

<i>Mycoplasma pneumoniae</i> Infection in Hong Kong – Clinical and Epidemiological Features during an Epidemic

Hosker

Tam²,

Chan³

et al. 1993

Respiration

View full text Add to dashboard Cite

An epidemic of infection due to Mycoplasma pneumoniae occurred in Hong Kong in 1986-1988. One hundred and seventy-nine cases were identified at the Prince of Wales Hospital over this period. Clinically significant infection predominantly affected children under 12 years, with 32% of all infections occurring in children aged between 6 and 11 years, and 39% in children between 1 and 5 years. Ninety-seven percent of childhood infections were respiratory in nature, the other 4 presentations were neuropsychiatric. Adequate information was available on 36 of the 43 subjects over 12 years. One teenager presented with acute psychosis; all other cases (35) were respiratory. In these cases cough was universal, and fever was present in 34 (97%). A variety of nonspecific symptoms (rigors/chills, malaise, headache, sore throat, sweating) were frequently noted. Sputum production was documented in 75% of cases, and was frequently purulent. Radiological consolidation was very common (95% of cases), but resolved fully after 4 weeks. Complications were rare and included acute pericarditis in 1 patient and haemolysis in another, and both patients recovered subsequently. Clinical recovery was otherwise rapid and complete in all other patients. Persisting dry cough was the only symptom documented at follow-up. Although infection due to M. pneumoniae in an ethnic Chinese population appears similar to that described in other populations, a higher incidence in younger children was recorded in this study.

show abstract

Mycoplasma pneumoniae and other pathogens in the aetiology of lower respiratory tract infections among Japanese children

Cited by 18 publications

References 14 publications

Immunoblotting patterns with Mycoplasma pneumoniae of serum specimens from infected and non-infected subjects

Immunoblotting patterns with Mycoplasma pneumoniae of serum specimens from infected and non-infected subjects

Community outbreak of acute respiratory infection by Mycoplasma pneumoniae

<i>Mycoplasma pneumoniae</i> Infection in Hong Kong – Clinical and Epidemiological Features during an Epidemic

Contact Info

Product

Resources

About