Mycoplasma pneumoniae among Chinese Outpatient Children with Mild Respiratory Tract Infections during the Coronavirus Disease 2019 Pandemic

Chen, Jiande; Lü, Zhiwei; Chen, Yu; Huang, Su; Li, Hengtao; Lin, Shuzhu; Yu, Jun; Zeng, Xueqi; Ji, Cuihong; Zheng, Yuejie; Fangfang, Dai; Dong, Wei; Xu, Huiting; Chen, Weichao; Xiaoqun, Jin; Cui, Zhen; Qiao, Jing; Wei, Qin; Chen, Hui; Jiang, Wei; Zhang, Xiaoying; Song, Jin H.; Shao, Jie; Su, Wenyu; Wang, Chao; Liu, Fang; Zhao, Yuhua; Zou, Yingxue; Guo, Run; Zhang, Lei; Wu, Jieqiong; Yuan, Shuo; Tang, Mingyu; Wu, Yulian; Lin, Jie; Dong, Wenfang; Chen, Xing; Sun, Xin; Yin, Yong

doi:10.1128/spectrum.01550-21

Cited by 16 publications

(12 citation statements)

References 34 publications

(48 reference statements)

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“…During the SARS-CoV-2 epidemic, co- infection related to M. pneumoniae has been largely overlooked, despite the disorder being a cause of symptoms similar to those of SARS-CoV-2, including respiratory impairment, skin lesions, non-specific neurological symptoms, and severe neurological complications [ 33 , 34 , 35 ]. Co-infection SARS-CoV-2 and bacterium M. pneumoniae infection has been uncommonly reported during the recent epidemic SARS-CoV-2 infection.…”

Section: Discussionmentioning

confidence: 99%

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SARS-CoV-2: The Impact of Co-Infections with Particular Reference to Mycoplasma pneumonia—A Clinical Review

et al. 2022

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We evaluated the published literature on SARS-CoV-2 by using the medical databases PubMed, Embase, Cochrane Library, Scopus, and Web of Science. In the searches, the Medical Subject Heading (MeSH) terms “SARS-CoV-2 and Mycoplasma pneumoniae” AND “co-infection SARS-CoV-2” were used. Studies describing co-infection with SARS-CoV-2 and Mycoplasma pneumoniae in children were included in the review. The study was conducted and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results: According to the PRISMA guidelines, of the 38 identified studies, 14 were conducted in children (children/adolescents 0–18 years), 6 of which were included in this review. In total, 5867 children under the age of 17 years were diagnosed with SARS-CoV-2 infection through real-time polymerase chain reaction analysis of nasopharyngeal swabs to detect viral RNA. Elevated serum IgM levels specific to Mycoplasma pneumoniae were observed in 534 children and were associated with a Kawasaki-like illness in one child. To date, all of the children are alive. Conclusion: This study underlines the importance of considering, depending on the clinical context, a possible co-infection between SARS-CoV-2 and atypical bacteria, such as Mycoplasma pneumoniae. Co-infections with other respiratory pathogens during the pandemic and hospital stay can cause mistakes in clinical diagnostic and drug treatment. Physicians should perform early differential diagnosis of SARS-CoV-2 in association with other infectious agents. Further studies are needed to have a real incidence of these co-infections and their impact on symptoms, course, and outcome of patients with SARS-CoV-2.

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Section: Discussionmentioning

confidence: 99%

“…The bacterium M. pneumoniae is a common pathogen causing respiratory diseases in children and the epidemiologic presence of this pathogen among outpatient children with mild respiratory tract infection was studied by Chen et al [ 33 ]. A total of 862 children coming from 15 Centers in China were enrolled.…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2: The Impact of Co-Infections with Particular Reference to Mycoplasma pneumonia—A Clinical Review

et al. 2022

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“…Chen et al published their results in Microbiology Spectrum , reporting the prevalence of M. pneumoniae infection in children with mild respiratory tract infections from January 2020 to June 2021 ( 5 ). Sauteur et al reported a decline in M. pneumoniae infections during the coronavirus disease 2019 (COVID-19) pandemic ( 6 ).…”

Section: Lettermentioning

confidence: 99%

Impact of COVID-19 on the Epidemiological Features of Mycoplasma pneumoniae Infection in Children with Community-Acquired Pneumonia in Henan, China

Guo

et al. 2023

Microbiol Spectr

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“…Recently, the number of cases with MP infections had decreased remarkably due to the pandemic of COVID-19, and the decreasing rate of MRMP has also been reported [ 21 ].…”

Section: Epidemiologymentioning

confidence: 99%

Recent Trends in the Epidemiology, Diagnosis, and Treatment of Macrolide-Resistant Mycoplasma pneumoniae

Oishi

Ouchi

2022

JCM

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Among Mycoplasma pneumoniae (MP) is one of the major pathogens causing lower respiratory tract infection. Macrolide-resistant Mycoplasma pneumoniae (MRMP) isolates have been increasing and has become a global concern, especially in East Asian countries. This affects the treatment of MP infection; that is, some patients with MRMP infections fever cannot be controlled despite macrolide therapy. Therefore, alternative therapies, including secondary antimicrobials, including tetracyclines, fluoroquinolones, or systemic corticosteroids, were introduced. However, there are insufficient data on these alternative therapies. Thus, this article provides reviews of the recent trends in the epidemiology, diagnosis, and treatment of MRMP.

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Mycoplasma pneumoniae among Chinese Outpatient Children with Mild Respiratory Tract Infections during the Coronavirus Disease 2019 Pandemic

Cited by 16 publications

References 34 publications

SARS-CoV-2: The Impact of Co-Infections with Particular Reference to Mycoplasma pneumonia—A Clinical Review

SARS-CoV-2: The Impact of Co-Infections with Particular Reference to Mycoplasma pneumonia—A Clinical Review

Impact of COVID-19 on the Epidemiological Features of Mycoplasma pneumoniae Infection in Children with Community-Acquired Pneumonia in Henan, China

Recent Trends in the Epidemiology, Diagnosis, and Treatment of Macrolide-Resistant Mycoplasma pneumoniae

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