Mycoplasma Pneumonia

Forsyth, B R; Chanock, R M

doi:10.1146/annurev.me.17.020166.002103

Cited by 20 publications

(4 citation statements)

References 26 publications

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“…Therefore pathological specimens of human M. pneumoniae pneumonia are rarely obtained. Pathological descriptions of this pneumonia include marked plasma cell-rich lymphocytic infiltration in peribronchial and perivascular areas, with accumulations of macrophages, neutrophils, and lymphocytes in the alveolar spaces, foci of interstitial pneumonia, and hyperplasia of type II pneumocytes ( Golden, 1944 ; Forsyth and Chanock, 1966 ; Meyers and Hirschman, 1972 ; Chan et al, 1999 ). Bronchiolitis and alveolitis with dense mononuclear cells infiltration, epithelioid cell granulation tissue filling alveolar ducts, organizing alveolar exudates, and hyaline membranes are characteristic findings in fulminant M. pneumoniae pneumonia ( Koletsky and Weinstein, 1980 ; Rollins et al, 1986 ; Ito et al, 1995 ; Ebnother et al, 2001 ; Izumikawa et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Correlation between Radiological and Pathological Findings in Patients with Mycoplasma pneumoniae Pneumonia

Tanaka

2016

Front. Microbiol.

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Studies focused on the pathological–radiological correlation of human Mycoplasma (M) pneumoniae pneumonia have rarely been reported. Therefore, we extensively reviewed the literature regarding pathological and radiological studies of Mycoplasma pneumonia, and compared findings between open lung biopsy specimen and computed tomography (CT). Major three correlations were summarized. (1) Peribronchial and perivascular cuffing characterized by mononuclear cells infiltration was correlated with bronchovascular bundles thickening on CT, which was the most common finding of this pneumonia. (2) Cellular bronchitis in the small airways accompanied with exudates or granulation tissue in the lumen revealed as centrilobular nodules on CT. (3) Neutrophils and exudates in the alveolar lumen radiologically demonstrated as air-space consolidation or ground-glass opacities. In M. pulmonis-infected mice model, pathologic patterns are strikingly different according to host cell-mediated immunity (CMI) levels; treatment with interleukin-2 lead to marked cellular bronchitis in the small airways and treatment with prednisolone or cyclosporin-A lead to neutrophils and exudates in the alveolar lumen. Patients with centrilobular nodules predominant radiologic pattern have a high level of CMI, measuring by tuberculin skin test. From these findings, up-regulation of host CMI could change radiological pattern to centrilobular nodules predominant, on the other hand down-regulation of host CMI would change radiological pattern to ground-glass opacity and consolidation. It was suggested the pathological features of M. pneumoniae pneumonia may be altered by the level of host CMI.

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Section: Introductionmentioning

confidence: 99%

Correlation between Radiological and Pathological Findings in Patients with Mycoplasma pneumoniae Pneumonia

Tanaka

2016

Front. Microbiol.

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“…Mycoplasma pneumoniae causes a wide spectrum of respiratory infection ranging from inapparent or mild upper respiratory tract infection to pneumonia. Although only 3-10 % of people infected with M. pneumoniae actually develop pneumonia (Forsyth & Chanock, 1966), the organism is the most common cause of primary atypical pneumonia, and in a study in Seattle, Washington it accounted for 20 % of all pneumonia cases in the general population (Foy et al 1970).…”

Section: Introductionmentioning

confidence: 99%

The specific IgM response toMycoplasma pneumoniaeinfection: interpretation and application to early diagnosis

Moule¹,

Caul²,

Wreghitt

1987

Epidemiol. Infect.

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Specific IgM antibody production in patients with serologically proven Mycoplasma pneumoniae infection by the complement fixation (CF) test was studied using a mu-capture ELISA. Sera from 79% of patients were found to be IgM positive. Patients could be divided into two groups relating to the amount of specific antibody produced. High levels of specific IgM (greater than or equal to 10 units) were more commonly found in younger patients. Seventy-six per cent of patients under the age of 20 produced relatively high levels of IgM compared to 35% of patients over the age of 20. In contrast, the number of patients who produced low or undetectable levels of IgM (less than 10 units) was found to increase with age. This trend was found to be significant which suggests that low or undetectable levels of IgM may be due to reinfection with M. pneumoniae. Specific IgM was found to appear in the serum at approximately 7 days after the onset of symptoms, peaking at between 10 and 30 days, and then falling to undetectable levels at an estimated 12-26 weeks post onset of symptoms. Twenty-eight per cent of acute-phase sera (CF titres less than 256) from patients whose sera subsequently showed a fourfold or greater rise in M. pneumoniae CF antibody titre were IgM positive. Thus using mu-capture ELISA a diagnosis of M. pneumoniae infection may often be made more rapidly than by the complement fixation test.

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“…2 Loraine, J., Bell, E., Harkness, R., Mears, E., and Jackson, M., Lancer, 1963, 2, 902. Junkmann, K., Mitt.…”

Section: Long-acting Contraceptivesmentioning

confidence: 99%

Long-acting contraceptives.

1966

BMJ

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Mycoplasma Pneumonia

Cited by 20 publications

References 26 publications

Correlation between Radiological and Pathological Findings in Patients with Mycoplasma pneumoniae Pneumonia

Correlation between Radiological and Pathological Findings in Patients with Mycoplasma pneumoniae Pneumonia

The specific IgM response toMycoplasma pneumoniaeinfection: interpretation and application to early diagnosis

Long-acting contraceptives.

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