Mycoplasma genitalium on the Loose: Time to Sound the Alarm

Manhart, Lisa E.

doi:10.1097/olq.0000000000000665

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…More information about the pattern of infection, clinical manifestations and biological ramifications of M. genitalium infection in MSM would inform testing guidelines. Furthermore, internationally there have been widespread reports of increasing M. genitalium resistance to azithromycin, a macrolide antibiotic used for first-line treatment 8. MSM populations may be particularly vulnerable to acquiring and transmitting macrolide resistant M. genitalium due to their higher risk of STIs and the increased likelihood of prior macrolide therapy.…”

Section: Introductionmentioning

confidence: 99%

Mycoplasma genitalium: high prevalence of resistance to macrolides and frequent anorectal infection in men who have sex with men in western Sydney

et al. 2018

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We demonstrated a high prevalence of and very high levels of macrolide resistance among MSM attending WSSHC. Our findings support the routine use of an assay to detect macrolide resistance mutations in infections. This will ensure, in regions or populations with high rates of macrolide resistance among strains, that first-line treatment with azithromycin will only be used if a macrolide-sensitive strain is identified.

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Section: Introductionmentioning

confidence: 99%

Mycoplasma genitalium: high prevalence of resistance to macrolides and frequent anorectal infection in men who have sex with men in western Sydney

et al. 2018

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“…Furthermore, it is resistant to antibiotics and treatment options are becoming more limited (Manhart, 2017). Animal studies are needed to comprehensively study the pathogenesis of M.…”

Section: Mycoplasma Genitaliummentioning

confidence: 99%

Contribution of the swine model in the study of human sexually transmitted infections

Käser

Renois

Wilson

et al. 2018

Infection, Genetics and Evolution

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The pig has garnered more and more interest as a model animal to study various conditions in humans. The growing success of the pig as an experimental animal model is explained by its similarities with humans in terms of anatomy, genetics, immunology, and physiology, by their manageable behavior and size, and by the general public acceptance of using pigs for experimental purposes. In addition, the immunological toolbox of pigs has grown substantially in the last decade. This development led to a boost in the use of pigs as a preclinical model for various human infections including sexually transmitted diseases (STIs) like Chlamydia trachomatis. In the current review, we discuss the use of animal models for biomedical research on the major human STIs. We summarize results obtained in the most common animal models and focus on the contributions of the pig model towards the understanding of pathogenesis and the host immune response. In addition, we present the main features of the porcine model that are particularly relevant for the study of pathogens affecting human female and male genital tracts. We also inform on the technological advancements in the porcine toolbox to facilitate new discoveries in this biologically important animal model. There is a continued need for improvements in animal modeling for biomedical research inclusive STI research. With all its advantages and the highly improved toolbox, the porcine model can play a crucial role in STI research and open the door to new exciting discoveries.

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Exploring the implications for coincidental treatment of Mycoplasma genitalium infection in Neisseria gonorrhoeae-positive patients

Mhango

Trembizki

Thng

et al. 2021

JAC-Antimicrobial Resistance

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Mycoplasma genitalium on the Loose: Time to Sound the Alarm

Cited by 4 publications

References 21 publications

Mycoplasma genitalium: high prevalence of resistance to macrolides and frequent anorectal infection in men who have sex with men in western Sydney

Mycoplasma genitalium: high prevalence of resistance to macrolides and frequent anorectal infection in men who have sex with men in western Sydney

Contribution of the swine model in the study of human sexually transmitted infections

Exploring the implications for coincidental treatment of Mycoplasma genitalium infection in Neisseria gonorrhoeae-positive patients

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