Mycoplasma gallisepticum induced exosomal gga-miR-193a to disturb cell proliferation, apoptosis, and cytokine production by targeting the KRAS/ERK signaling pathway

Zou, Meiling; Fu, Yali; Zhao, Yabo; Sun, Yingfei; Yin, Xun; Peng, Xiuli

doi:10.1016/j.intimp.2022.109090

Cited by 3 publications

(1 citation statement)

References 40 publications

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“…Following M. gallisepticum infection, exosomes secreted from M. gallisepticum -infected alveolar epithelial cells can cause or exacerbate lung inflammation and significantly increase TNF-α and IL-1β protein levels in DF-1 cells [ 95 ]. Gga-miR-193a content increased in exosomes to disturb distal cell proliferation, apoptosis, and cytokine production by targeting the KRAS/ERK signaling pathway [ 102 ] and gga-miR-451 was significantly reduced in exosomes, enhancing the inflammatory response in DF-1 cells, although gga-miR-451 expression was highly significantly upregulated in M. gallisepticum -infected CP-II cells [ 90 ]. In addition, the inflammatory response is critical in modulating the host’s immune response to pathogens such as bacteria, viruses, and parasites but a strong inflammatory immune response is an important cause of CRD.…”

Section: Escape From Innate Immune Responsementioning

confidence: 99%

Immune Evasion of Mycoplasma gallisepticum: An Overview

Liu,

Wang,

Zheng

2024

IJMS

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Mycoplasma gallisepticum is one of the smallest self-replicating organisms. It causes chronic respiratory disease, leading to significant economic losses in poultry industry. Following M. gallisepticum invasion, the pathogen can persist in the host owing to its immune evasion, resulting in long-term chronic infection. The strategies of immune evasion by mycoplasmas are very complex and recent research has unraveled these sophisticated mechanisms. The antigens of M. gallisepticum exhibit high-frequency changes in size and expression cycle, allowing them to evade the activation of the host humoral immune response. M. gallisepticum can invade non-phagocytic chicken cells and also regulate microRNAs to modulate cell proliferation, inflammation, and apoptosis in tracheal epithelial cells during the disease process. M. gallisepticum has been shown to transiently activate the inflammatory response and then inhibit it by suppressing key inflammatory mediators, avoiding being cleared. The regulation and activation of immune cells are important for host response against mycoplasma infection. However, M. gallisepticum has been shown to interfere with the functions of macrophages and lymphocytes, compromising their defense capabilities. In addition, the pathogen can cause immunological damage to organs by inducing an inflammatory response, cell apoptosis, and oxidative stress, leading to immunosuppression in the host. This review comprehensively summarizes these evasion tactics employed by M. gallisepticum, providing valuable insights into better prevention and control of mycoplasma infection.

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Section: Escape From Innate Immune Responsementioning

confidence: 99%

Immune Evasion of Mycoplasma gallisepticum: An Overview

Liu,

Wang,

Zheng

2024

IJMS

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Lactobacillus salivarius ameliorates Mycoplasma gallisepticum-induced inflammation via the JAK/STAT signaling pathway involving respiratory microbiota and metabolites

Wang,

Miao,

Liu

et al. 2024

Poultry Science

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Exosomal microRNA/miRNA Dysregulation in Respiratory Diseases: From Mycoplasma-Induced Respiratory Disease to COVID-19 and Beyond

Wang,

Zou,

Zhao

et al. 2023

Cells

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Respiratory diseases represent a significant economic and health burden worldwide, affecting millions of individuals each year in both human and animal populations. MicroRNAs (miRNAs) play crucial roles in gene expression regulation and are involved in various physiological and pathological processes. Exosomal miRNAs and cellular miRNAs have been identified as key regulators of several immune respiratory diseases, such as chronic respiratory diseases (CRD) caused by Mycoplasma gallisepticum (MG), Mycoplasma pneumoniae pneumonia (MMP) caused by the bacterium Mycoplasma pneumoniae, coronavirus disease 2019 (COVID-19), chronic obstructive pulmonary disease (COPD), asthma, and acute lung injury/acute respiratory distress syndrome (ALI/ARDS). Consequently, miRNAs seem to have the potential to serve as diagnostic biomarkers and therapeutic targets in respiratory diseases. In this review, we summarize the current understanding of the functional roles of miRNAs in the above several respiratory diseases and discuss the potential use of miRNAs as stable diagnostic biomarkers and therapeutic targets for several immune respiratory diseases, focusing on the identification of differentially expressed miRNAs and their targeting of various signaling pathways implicated in disease pathogenesis. Despite the progress made, unanswered questions and future research directions are discussed to facilitate personalized and targeted therapies for patients with these debilitating conditions.

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Mycoplasma gallisepticum induced exosomal gga-miR-193a to disturb cell proliferation, apoptosis, and cytokine production by targeting the KRAS/ERK signaling pathway

Cited by 3 publications

References 40 publications

Immune Evasion of Mycoplasma gallisepticum: An Overview

Immune Evasion of Mycoplasma gallisepticum: An Overview

Lactobacillus salivarius ameliorates Mycoplasma gallisepticum-induced inflammation via the JAK/STAT signaling pathway involving respiratory microbiota and metabolites

Exosomal microRNA/miRNA Dysregulation in Respiratory Diseases: From Mycoplasma-Induced Respiratory Disease to COVID-19 and Beyond

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