Mycophenolate mofetil for psoriasis

Kirby,; Yates,

doi:10.1046/j.1365-2133.1998.02391.x

Cited by 8 publications

(7 citation statements)

References 7 publications

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“…Given the low toxicity of MPA, the only concern is its role in unwanted immunosuppression . The extensive use of MPA in medicine has indicated that these concerns are minimal .…”

Section: Formation Toxicity and Occurrence Of Emerging Mycotoxinsmentioning

confidence: 99%

“…250 Given the low toxicity of MPA, the only concern is its role in unwanted immunosuppression. 251 The extensive use of MPA in medicine has indicated that these concerns are minimal. 239 Levels in food do not even come close to therapeutic doses in humans, so it is safe to assume that MPA should also not be of any dietary concern.…”

Section: Journal Of Agricultural and Food Chemistrymentioning

confidence: 99%

See 1 more Smart Citation

Emerging Mycotoxins: Beyond Traditionally Determined Food Contaminants

Gruber-Dorninger¹,

Novak²,

Nagl³

et al. 2016

J. Agric. Food Chem.

304

212

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Modern analytical techniques can determine a multitude of fungal metabolites contaminating food and feed. In addition to known mycotoxins, for which maximum levels in food are enforced, also currently unregulated, so-called "emerging mycotoxins" were shown to occur frequently in agricultural products. The aim of this review is to critically discuss the relevance of selected emerging mycotoxins to food and feed safety. Acute and chronic toxicity as well as occurrence data are presented for enniatins, beauvericin, moniliformin, fusaproliferin, fusaric acid, culmorin, butenolide, sterigmatocystin, emodin, mycophenolic acid, alternariol, alternariol monomethyl ether, and tenuazonic acid. By far not all of the detected compounds are toxicologically relevant at their naturally occurring levels and are therefore of little or no health concern to consumers. Still, gaps in knowledge have been identified for several compounds. These gaps should be closed by the scientific community in the coming years to allow a proper risk assessment.

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“…Given the low toxicity of MPA, the only concern is its role in unwanted immunosuppression . The extensive use of MPA in medicine has indicated that these concerns are minimal .…”

Section: Formation Toxicity and Occurrence Of Emerging Mycotoxinsmentioning

confidence: 99%

Section: Journal Of Agricultural and Food Chemistrymentioning

confidence: 99%

Emerging Mycotoxins: Beyond Traditionally Determined Food Contaminants

Gruber-Dorninger¹,

Novak²,

Nagl³

et al. 2016

J. Agric. Food Chem.

304

212

View full text Add to dashboard Cite

show abstract

“…[156][157][158] However, in 1997 it was stated that "the question of MPA's role in immunosuppression, the increased incidence of latent viral infections, and the question of carcinogenicity led to the discontinuation of the majority of investigations of MPA as a treatment for psoriasis". 159,160 Psoriasis has also been treated with a prodrug form of MPA (see below).…”

Section: B Use Of Mycophenolic Acidmentioning

confidence: 99%

“…In the previously mentioned work on the treatment of psoriasis, it was noted that use of MPA had actually been discontinued because of uncertainty of the longterm role of MPA in immunosuppression and because there were concerns regarding the incidence of latent viral infections and potential carcinogenicity. 160 The extensive use of MMF in other situations (and also for psoriasis) has apparently indicated that these concerns are minimal. One recent report concerns patients receiving MMF for periods from two months to three years.…”

Section: Mycophenolate Mofetil a Prodrugmentioning

confidence: 99%

Mycophenolic Acid: A One Hundred Year Odyssey from Antibiotic to Immunosuppressant

2000

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“…20 This success of MMF in treating otherwise resistant psoriatics, including one case of erythrodermic psoriasis, 21 has been confirmed by others. [22][23][24][25][26][27] One of the largest studies to date demonstrated improvement, as measured by reduction in their Psoriasis Area and Severity Index (PASI) scores, in seven of 11 patients within 3 weeks of MMF therapy (2 g/d). 28 Promise exists for use of topical mycophenolate in the MMF form, even though topical mycophenolate in the MPA form has not been effective in treating psoriasis.…”

Section: Psoriasismentioning

confidence: 98%

Mycophenolate in dermatology

Liu

Mackool

2003

Journal of Dermatological Treatment

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Originally used to treat psoriasis nearly three decades ago, mycophenolic acid, reformulated as mycophenolate mofetil (MMF), has been rediscovered by the world of dermatology. As a relatively well-tolerated immunosuppressive used in organ transplant recipients, MMF has recently been reported to show promise for several dermatologic conditions, including psoriasis, pemphigus vulgaris, pyoderma gangrenosum, bullous lichen planus, and even connective tissue diseases such as lupus erythematosus and dermatomyositis. Although not intended to be exhaustive, this review discusses MMF with regard to its basic pharmacology, its side effects, and its reported efficacy in a variety of dermatologic indications. Relevant literature was retrieved by a Medline search combining the terms "mycophenolate" or "mycophenolic acid" and "skin" or "skin disease" or a number of specific conditions ("psoriasis", "dermatitis", "eczema", "pemphigoid", "pemphigus", "vasculitis", "pyoderma gangrenosum", "Crohn's disease", "graft-versus-host disease", "lichen planus"). As MMF has only been recently re-introduced for dermatologic application, the nature of much of the literature is admittedly that of case reports or case series. Nevertheless, the results are sufficiently promising to warrant further larger, control studies.

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Mycophenolate mofetil for psoriasis

Cited by 8 publications

References 7 publications

Emerging Mycotoxins: Beyond Traditionally Determined Food Contaminants

Emerging Mycotoxins: Beyond Traditionally Determined Food Contaminants

Mycophenolic Acid: A One Hundred Year Odyssey from Antibiotic to Immunosuppressant

Mycophenolate in dermatology

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