Mycoleptodonoides�aitchisonii suppresses asthma via Th2 and Th1 cell regulation in an ovalbumin‑induced asthma mouse model

Abstract

Asthma is a chronic respiratory disease related to hyper-responsiveness. The majority of patients suffer mild symptoms, however, some cases, especially in the young and the elderly, can lead to death by apnea. Mycoleptodonoides atichisonii (M. atichisonii) is an edible mushroom that has previously been reported to possess several bioactive properties, such as the synthesis of nerve growth factors, anti-obesity effects and the ability to prevent cell death. In the current study, the authors evaluated the anti-asthmatic effects of M. atichisonii using an ovalbumin-induced asthma mouse model. M. atichisonii dose-dependently suppressed the levels of white blood cells, eosinophils and immunoglobulin (Ig)E in BALB/c mice, resulting from ovalbumin-induced asthma. M. atichisonii recovered the typical asthmatic morphological changes in lungs, such as mucous hyper-secretion, epithelial layer hyperplasia, eosinophil infiltration and various cell surface molecules, such as CD3, CD4, CD8, CD19 and major histocompatibility complex class II. With the exception of CD19+ cells and IL-12p40, M. atichisonii affected almost all factors related to asthma induction including the T helper (Th)1/Th2 transcription factors, T-bet and GATA-3, Th1-related cytokines, Th2-related cytokines and proinflammatory cytokines. In addition, M. atichisonii significantly inhibited the expression of IL-5, IL-13 and IL-6. The authors concluded that M. atichisonii may be a promising drug candidate against asthma.

Socheongryongtang Modulates Asthma-Related Changes via Modulation of TNF-α and T-bet as well as IFN-γ in an Asthma Murine Model

“…Based on the results, we found that socheongryongtang could not modulate the eosinophil level but could control the change of neutrophil in the asthma model. IgE is one of the important biomarkers for hyperresponsiveness criteria which significantly increases in asthma patients [36] and in the ovalbumin-induced asthma animal model [9,10]. Like the reported results in the ovalbumin treatment group, the expression level of IgE significantly increased compared to that in control ( Figure 2C).…”

“…According to a WHO report, in 2015 383,000 deaths were caused by asthma, and the worldwide number of patients might be 235 million [1]. As there are a lot of causes of asthma everywhere around us [41], it is impossible to perfectly cure it [42], and most anti-asthmatic drugs which have been used have several adverse effects such as growth control in the young [7], hypertension, hyperlipidemia, peptic ulcers, immunological suppression, etc [8], so there are many trials aimed at developing new anti-asthmatic drugs from natural products [9,10]. Asthma inducers are called allergens and are classified into two groups: indoor allergens and outdoor allergens.…”

“…Therefore, for several decades there have been many trials to identify anti-asthmatic drug candidates which are more effective and less toxic [9][10][11][12]. In particular, many have attempted to develop medications for asthma based on the traditional prescriptions/drugs through the investigation of the mechanisms and/or modes of action.…”

Porphyromonas�gingivalis induced inflammatory responses and promoted apoptosis in lung epithelial cells infected with H1N1 via the Bcl‑2/Bax/Caspase‑3 signaling pathway

“…In addition, previous investigation has provided information on the formation and maintenance of good oral health ( 11 ). Epidemiological surveys demonstrated that the risk of respiratory disease is increased due to mouth-breathing habits and periodontal disease, which may be due to the airflow via the oral cavity, the lower respiratory tract and the lungs, thereby introducing periodontal pathogens into the lungs where an infection may occur ( 12 , 13 ).…”

LncRNA-AK149641 associated with airway inflammation in an OVA-induced asthma mouse model

“…IL-6, an inhibitor of T helper 1 (Th1) differentiation, is a significant modulator of effector CD4+ T cell differentiation and IL-4 production during the process of Th2 differentiation. The ability of regulating Th1 and Th2 differentiation makes IL-6 become a crucial factor in the onset of asthma (Dienz and Rincon 2009 ; Lee et al 2017 ; Neveu et al 2010 ).…”