Mycoleptodiscins A and B, Cytotoxic Alkaloids from the Endophytic Fungus <i>Mycoleptodiscus</i> sp. F0194

Ortega, Humberto E.; Graupner, Paul R.; Asai, Yumi; Tendyke, Karen; Qiu, Dayong; Shen, Yongchun; Ríos, Nivia; Arnold, A. Elizabeth; Coley, Phyllis D.; Kursar, Thomas A.; Gerwick, William H.; Cubilla‐Rios, Luis

doi:10.1021/np300792t

Cited by 46 publications

(21 citation statements)

References 16 publications

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“…Siriwach et al (2012) isolated a new chromone derivative, Mycoleptione, from Mycoleptodiscus sp MU41. Two novel reddish-orange alkaloids were also isolated from Mycoleptodiscus sp, which was obtained from Desmotes incomparabilis in Panama (Ortega et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

A cultured endophyte community is associated with the plant Clerodendrum inerme and antifungal activity

Gong¹,

Xh²,

Yq³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Fungal endophytes live in the inner tissues of Clerodendrum inerme and may be significant resources for new chemicals in drug discovery. A total of 242 endophytic fungi were recovered from 602 sample segments of C. inerme; 66 were purified. The 66 fungi belonging to 16 taxa and 11 genera (Alternaria, Nigrospora, Bartalinia, Pestalotiopsis, Fusarium, Mycoleptodiscus, Trichoderma, Phomopsis, Diaporthe, Lasiodiplodia, and Curvularia) were identified by morphological characteristics and fungal internal transcribed spacer sequences. The most abundant genera were Alternaria and Lasiodiplodia. Some of the endophytes exhibited tissue specificity. The colonization frequencies of endophytes in the stems were evidently higher than those in the roots and leaves. The crude ethyl acetate extracts were tested against 6 endophytes isolated from C. inerme. Three of 10 (33.3%) endophytes, which were identified as Phomopsis sp, Curvularia sp, and Mycoleptodiscus sp, displayed distinct antifungal activity against ≥3 tested fungi. To our knowledge, this is the first report of an endophytic community associated with C. inerme in China and its antifungal activity in vitro.

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Section: Discussionmentioning

confidence: 99%

A cultured endophyte community is associated with the plant Clerodendrum inerme and antifungal activity

Gong¹,

Xh²,

Yq³

et al. 2015

Genet. Mol. Res.

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“…Regardless of the nature of these symbioses, foliar fungal endophytes represent a cryptic reservoir of biodiversity. Understanding factors shaping the distribution of these fungi could also aid bioprospecting efforts that aim to discover diverse secondary metabolites and novel bioactive compounds (Higginbotham et al 2013;Ortega et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Host associations and beta diversity of fungal endophyte communities in New Guinea rainforest trees

2016

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Processes shaping the distribution of foliar fungal endophyte species remain poorly understood. Despite increasing evidence that these cryptic fungal symbionts of plants mediate interactions with pathogens and herbivores, there remain basic questions regarding the extent to which dispersal limitation and host specificity might shape fungal endophyte community composition in rainforests. To assess the relative importance of spatial pattern and host specificity, we isolated fungi from a sample of mapped trees in lowland Papua New Guinea. Sequences of the internal transcribed spacer (ITS) region were obtained for 2079 fungal endophytes from three sites and clustered into molecular operational taxonomic units (MOTUs) at 95% similarity. Multivariate analyses suggest that host affinity plays a significant role in structuring endophyte community composition whereas there was no evidence of endophyte spatial pattern at the scale of tens to hundreds of metres. Differences in endophyte communities between sampled trees were weakly correlated with variation in foliar traits but not with tree species relatedness. The dominance of relatively few generalist endophytes and the presence of a large number of rare MOTUs was a consistent observation at three sites separated by hundreds of kilometres and regional turnover was low. Host specificity appears to play a relatively weak but more important role than dispersal limitation in shaping the distribution of fungal endophyte communities in New Guinea forests. Our results suggest that in the absence of strong ecological gradients and host turnover, beta diversity of endophyte communities could be low in large areas of contiguous forest.

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“…Compound 324 was tested against the four cancer cell lines H460, A2058 (human melanoma), H522-T1 (non-small cell lung cancer), and PC-3 (prostate cancer), showing strong cytotoxicity, with IC 50 values ranging from 0.60 to 0.78 μM. However, this compound was also strongly cytotoxic against nonproliferating normal cells (IMR-90, IC 50 0.41 μM), indicating an indiscriminant cytotoxicity [90].…”

Section: Fig 82 (Continued)mentioning

confidence: 99%

Endophytic Fungi as a Source of Novel Metabolites

2015

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Mycoleptodiscins A and B, Cytotoxic Alkaloids from the Endophytic Fungus Mycoleptodiscus sp. F0194

Cited by 46 publications

References 16 publications

A cultured endophyte community is associated with the plant Clerodendrum inerme and antifungal activity

A cultured endophyte community is associated with the plant Clerodendrum inerme and antifungal activity

Host associations and beta diversity of fungal endophyte communities in New Guinea rainforest trees

Endophytic Fungi as a Source of Novel Metabolites

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