Mycofabricated biosilver nanoparticles interrupt Pseudomonas aeruginosa quorum sensing systems

Singh, Braj Raj; Singh, Brahma N.; Singh, Akanksha; Khan, Wasi; Naqvi, Andleeb Z.; Singh, Harikesh Bahadur

doi:10.1038/srep13719

Cited by 154 publications

(113 citation statements)

References 47 publications

(73 reference statements)

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“…Therefore, any interference with the swarming motility is bound to effect * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * Figure S1). Results obtained in the present study are comparable to the decrease in swarming motility reported in recent studies for mycofabricated silver nanoparticles [46], Ag nanoparticles synthesized from Sargassum polyphyllum [57], and green zinc oxide nanostructures [24].…”

Section: Inhibition Of Eps and Swarmingsupporting

confidence: 80%

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Biofabrication of Zinc Oxide Nanoparticle fromOchradenus baccatusLeaves: Broad-Spectrum Antibiofilm Activity, Protein Binding Studies, andIn VivoToxicity and Stress Studies

Al‐Shabib

Husain

Hassan

et al. 2018

Journal of Nanomaterials

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Biofilms are complex aggregation of cells that are embedded in EPS matrix. These microcolonies are highly resistant to drugs and are associated with various diseases. Biofilms have greatly affected the food safety by causing severe losses due to food contamination and spoilage. Therefore, novel antibiofilm agents are needed. This study investigates the antibiofilm and protein binding activity of zinc nanoparticles (ZnNPs) synthesized from leaf extract of Ochradenus baccatus. Standard physical techniques, including UVvisible spectroscopy Fourier transform infrared spectroscopy and X-ray diffraction and transmission electron microscopy, were used to characterize the synthesized OB-ZnNPs. Synthesized OB-ZnNPs demonstrated significant biofilm inhibition in human and food-borne pathogens (Chromobacterium violaceum, Escherichia coli, P. aeruginosa, Klebsiella pneumoniae, Serratia marcescens, and Listeria monocytogenes) at subinhibitory concentrations. OB-ZnNPs significantly reduced the virulence factors like violacein, prodigiosin, and alginate and impaired swarming migration and EPS production. OB-ZnNPs demonstrated efficient binding with HSA protein and no change in their structure or stability was observed. In addition, in vivo toxicity evaluation confirmed that OBZnNPs possessed no serious toxic effect even at higher doses. Moreover, they were found to have excellent antioxidant properties that can be employed in the fields of food safety and medicine. Hence, it is envisaged that the OB-ZnNPs can be used as potential nanomaterials to combat drug resistant bacterial infections and prevent contamination/spoilage of food.

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Section: Inhibition Of Eps and Swarmingsupporting

confidence: 80%

“…Inhibition of alginate production would reduce the rate of resistance among bacteria and make them susceptible to the drugs. Previously, mycofabricated biosilver nanoparticles have been shown to inhibit alginate production in P. aeruginosa [46].…”

Section: Inhibition Of Alginate Production In P Aeruginosa Pao1mentioning

confidence: 99%

Biofabrication of Zinc Oxide Nanoparticle fromOchradenus baccatusLeaves: Broad-Spectrum Antibiofilm Activity, Protein Binding Studies, andIn VivoToxicity and Stress Studies

Al‐Shabib

Husain

Hassan

et al. 2018

Journal of Nanomaterials

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“…They hypothesized that acquired apoptotic resistance might be a key aspect of cadmium-induced malignant transformation of prostate epithelial cells and could contribute to both tumour initiation and the acquisition of aggressive characteristics subsequent to tumour formation. However, other researchers (Singh et al, 2012) have identified this self destructive cell (apoptotic) process as the key to finding a method of destroying prostate cancer cells.…”

Section: Heavy and Toxic Metalsmentioning

confidence: 99%

“…Additional studies are needed to reveal the factors that influence the expression of MT in prostate epithelial cells, and to analyze the free and compound forms of Cd at the same time. Singh et al, (2012) India Laboratory Investigation…”

Section: -2002 National Health and Nutrition Examination Survey (mentioning

confidence: 99%

An Update on Occupation and Prostate Cancer

Doolan¹,

Benke²,

Giles³

2014

Asian Pacific Journal of Cancer Prevention

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Background: Our aim was to identify gaps and limitations in the current literature and to make recommendations for future research required to address these. Materials and Methods: We reviewed occupational exposures and related factors associated with the risk of prostate cancer between 2000 and 2012. These included chemical, ergonomic, physical or environmental, and psychosocial factors which have been reported by epidemiological studies across a range of industries. Results: The results are inconsistent from study to study and generally this is due to the reliance upon the retrospectivity of case-control studies and prevalence (ecological) studies. Exposure assessment bias is a recurring limitation of many of the studies in this review. Conclusions: We consider there is insufficient evidence to implicate prostate cancer risk for ergonomic, physical, environmental or psychosocial factors, but there is sufficient evidence to implicate toxic metals, polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs). More research is required to identify specific pesticides that may be associated with risk of prostate cancer.

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“…Higher activity of caspase-3 and caspase-9 was noted in QDs treated cancer cells. Finally, due to the induction of caspasedependent apoptotic cell death of cancer cells, it is suggest that biologically stabilized CdS-QDs bear the potential to be apply in biomedicine, specifically in tumor therapy (Singh et al, 2012).…”

Section: Cadmium Quantum Dotsmentioning

confidence: 99%

Nanoparticle Induced Oxidative Stress in Cancer Cells: Adding New Pieces to an Incomplete Jigsaw Puzzle

Nogueira¹,

Rolim²,

Farooqı³

2014

Asian Pacific Journal of Cancer Prevention

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Nanotechnology is an emerging field with many promising applications in drug delivery systems. Because of outstanding developments in this field, rapidly increasing research is directed to the development of nanocarriers that may enhance the availability of drugs to the target sites. Substantial fraction of information has been added into the existing scientific literature focusing on the fact that nanoparticles usually generate reactive oxygen species to a greater extent than micro-sized particles. It is worth mentioning that oxidative stress regulates an array of cell signaling cascades that resulted in cancer cell damage. Accumulating experimental evidence over the years has shown that wide-ranging biological mechanisms are triggered by these NPs in cultured cells due to the unique properties of engineered nanoparticles. In this review, we have attempted to provide an overview of the signaling cascades that are activated by oxidative stress in cancer cells in response to different kinds of nanomaterials, including quantum dots, metallic and polymeric nanoparticles.

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Mycofabricated biosilver nanoparticles interrupt Pseudomonas aeruginosa quorum sensing systems

Cited by 154 publications

References 47 publications

Biofabrication of Zinc Oxide Nanoparticle fromOchradenus baccatusLeaves: Broad-Spectrum Antibiofilm Activity, Protein Binding Studies, andIn VivoToxicity and Stress Studies

Biofabrication of Zinc Oxide Nanoparticle fromOchradenus baccatusLeaves: Broad-Spectrum Antibiofilm Activity, Protein Binding Studies, andIn VivoToxicity and Stress Studies

An Update on Occupation and Prostate Cancer

Nanoparticle Induced Oxidative Stress in Cancer Cells: Adding New Pieces to an Incomplete Jigsaw Puzzle

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