Mycobiota and C-Type Lectin Receptors in Cancers: Know thy Neighbors

Zhang, Lilong; Chai, Dongqi; Chen, Chen; Li, Chunlei; Qiu, Zhendong; Kuang, Tianrui; Parveena, Mungur; Dong, Kai; Yu, Jia; Deng, Wenhong; Wang, Weixing

doi:10.3389/fmicb.2022.946995

Cited by 11 publications

(11 citation statements)

References 168 publications

(278 reference statements)

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“…However, contrary to our expectation, we found both cell lines expressed comparable amounts of dectin-2 protein (12). A recent study suggested that dectin-1, another C-type lectin receptor (14), has a role distinct from that of dectin-2 in skin wound-healing through its different effects on neutrophilic inflammatory response (18). Therefore, in order to clarify the possible role of dectin-1 in UVC sensitivity, dectin-1 protein expression was compared in UVC-sensitive and -resistant cells.…”

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confidence: 99%

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Prominent Anti-UVC Activity of Lignin Degradation Products

Sakagami

Amano

Uota

et al. 2022

In Vivo

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Background/Aim: The rapid spread of COVID-19 resulted in the revision of the value of ultraviolet C (UVC) sterilization in working spaces. This study aimed at re-evaluating the anti-UVC activity of four groups of natural products against human melanoma COLO679 and human normal dermal fibroblast (HDFa) cells, based on chemotherapeutic index. Materials and Methods: Various cell lines were exposed to UVC for 3 min in the presence of increasing concentrations of test compounds and viable cell numbers were determined with the 3-( 4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide assay. The anti-UVC activity was quantified by the ratio of the 50% cytotoxic concentration (determined without irradiation) to the 50% effective concentration (which abolished by 50% the UVCinduced loss of viability). Apoptosis was quantified as the subG 1 population proportion following cell-cycle analysis. Results: Among four groups of major natural products, six phenylpropanoids showed the highest anti-UVC activity, followed by the lignified products and alkaline products that contain lignin and its degradation products. On the other hand, tannins and flavonoids showed lower activity due to their higher cytotoxicity. UVC-sensitive COLO679 cells lack dectin-1 protein expression. Conclusion: These data suggest the prominent anti-UVC activity of lignin degradation products, and the possible involvement of dectin-1 expression in UVC-sensitivity.

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“…We reported the prominent anti-UVC activity of lignincarbohydrate complex (LCC) (13). LCC from Lentinus edodes mycelia extract enhanced gene expression of dectin-2, a C-type lectin receptor (14) which recognizes microbial polysaccharides (15). This suggests a significant role of the activation of the dectin-2 signaling pathway as a result of LCC action.…”

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confidence: 99%

Prominent Anti-UVC Activity of Lignin Degradation Products

Sakagami

Amano

Uota

et al. 2022

In Vivo

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“…Aflatoxins (mycotoxins produced by secondary metabolism of the fungus Aspergillus flavus and Aspergillus parasiticus ) are known to induce HCC [ 17 ]. In addition to the carcinogenic role of mycotoxins, several studies have shown that the intestinal mycobiota is directly involved in the development of colorectal, oral, and pancreatic cancer [ 18 – 26 ], and multicentre clinical research has revealed that gut fungi can be used for the diagnosis of colorectal cancer [ 19 ].…”

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confidence: 99%

Characterization of the intestinal fungal microbiome in patients with hepatocellular carcinoma

et al. 2023

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Objective Gut mycobiota plays a crucial role in benign liver diseases; however, its correlation with hepatocellular carcinoma (HCC) remains elusive. This study aimed to elucidate fungal differences in patients with HCC-associated cirrhosis compared to cirrhotic patients without HCC and healthy controls. Methods The 72 fecal samples from 34 HCC patients, 20 cirrhotic patients, and 18 healthy controls were collected and analyzed using ITS2 rDNA sequencing. Results Our results revealed the presence of intestinal fungal dysbiosis with significant enrichment of opportunistic pathogenic fungi such as Malassezia, Malassezia sp., Candida, and C. albicans in HCC patients compared with healthy controls and cirrhosis patients. Alpha-diversity analysis demonstrated that patients with HCC and cirrhosis showed decreased fungal diversity compared to healthy controls. Beta diversity analysis indicated that the three groups exhibited significant segregated clustering. Besides, C. albicans was found to be significantly more abundant in the HCC patients with TNM stage III-IV than those with stage I-II, in contrast to the commensal organism S. cerevisiae. We also confirmed that the HCC patients were successfully classified with an area under the curve value of 0.906 based on the fecal fungal signature. Finally, our animal experiments confirm that aberrant colonization of the intestine by C. albicans and M. furfur can promote the development of HCC. Conclusions This study indicates that dysbiosis of the gut mycobiome might be involved in HCC development. Trial registration: ChiCTR, ChiCTR2100054537. Registered 19 December 2021, http://www.chictr.org.cn/edit.aspx?pid=144550&htm=4

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“…Recently, Aykut et al made the groundbreaking discovery that fungi could move from the intestinal lumen to the pancreas and that pathogenic fungi stimulate pancreatic adenocarcinoma via activating the mannosebinding lectin/complement-3 pathway (Aykut et al, 2019). Our previous review also detailed the close relationship between intestinal fungi and cancers of the colorectum, cavity, stomach, esophagus, and pancreas (Zhang et al, 2022). Thus, it is necessary to perform further studies regarding the changes in the composition of fecal fungi in the progression from health to ICC, thereby providing a new theoretical basis for the prevention and treatment of ICC.…”

Section: Introductionmentioning

confidence: 99%

Alterations of gut mycobiota profiles in intrahepatic cholangiocarcinoma

Zhang

Chen²,

Chai³

et al. 2023

Front. Microbiol.

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ObjectiveIntrahepatic cholangiocarcinoma (ICC) is a silent liver malignancy with an increasing incidence. Gut mycobiota plays a crucial role in benign liver diseases; however, its correlation with ICC remains elusive. This study aimed to elucidate fungal differences in patients with ICC compared to healthy controls.MethodsThe 40 fecal samples from 23 ICC patients and 17 healthy controls were collected and analyzed using ITS2 rDNA sequencing. Obtaining the OTUs and combining effective grouping, we carried out the biodiversity and composition of the fungi, as well as FUNGuild functional annotation.ResultsOur results revealed the presence of intestinal fungal dysbiosis with significant enrichment of opportunistic pathogenic fungi such as Candida and C. albicans, and significant depletion of the beneficial fungus Saccharomyces cerevisiae in ICC patients compared with healthy controls. Alpha-diversity analysis demonstrated that patients with ICC showed decreased fungal diversity compared to healthy controls. Beta diversity analysis indicated that the two groups exhibited significant segregated clustering. Besides, C. albicans was found to be significantly more abundant in the ICC patients with TNM stage III-IV than those with stage I-II. The FUNGuild functional classification predicted that pathotrophs were the most abundant taxon in the ICC group, well above their abundance in healthy controls.ConclusionThis study indicates that dysbiosis of the fecal mycobiome might be involved in ICC development. Further research into gut fungi may contribute to new therapeutic options for ICC patients.

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Mycobiota and C-Type Lectin Receptors in Cancers: Know thy Neighbors

Cited by 11 publications

References 168 publications

Prominent Anti-UVC Activity of Lignin Degradation Products

Prominent Anti-UVC Activity of Lignin Degradation Products

Characterization of the intestinal fungal microbiome in patients with hepatocellular carcinoma

Alterations of gut mycobiota profiles in intrahepatic cholangiocarcinoma

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