Mycobacterium ulcerans infection in Ashanti region, Ghana

Werf, Tjip S. van der; Graaf, Winette T.A. van der; Groothuis, D.G.; Knell, A.J.

doi:10.1016/0035-9203(89)90521-x

Cited by 71 publications

(41 citation statements)

References 18 publications

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“…4,5,8 Children were predominantly affected. Hospitalization was prolonged, reflecting the severity of cases at the time of presentation.…”

Section: Discussionmentioning

confidence: 99%

“…9 The first suspected case of Buruli ulcer in Ghana was reported at the Korle-Bu Teaching Hospital in Accra in 1971. 10 Since then, other cases have been described: 96 cases in Ashanti Akim north, 4 90 cases in the Amansie West district, 5 and recently another 105 cases in the Amansie West district. 6 Buruli ulcer has been known in endemic communities for years.…”

mentioning

confidence: 99%

“…The increasing number of cases in recent years in West Africa has raised serious health concerns. Cases have been reported in Benin, 2,3 Ghana, [4][5][6] Togo, 1 Cote d'Ivoire, 7,8 and Liberia. 9 The first suspected case of Buruli ulcer in Ghana was reported at the Korle-Bu Teaching Hospital in Accra in 1971.…”

mentioning

confidence: 99%

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Socioeconomic implications of Buruli ulcer in Ghana: a three-year review.

Asiedu¹,

Etuaful²

1998

The American Journal of Tropical Medicine and Hygiene

186

183

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Abstract. This study examines some of the socioeconomic cost of treating 102 cases of Buruli ulcer between 1994 and 1996 at the St. Martin's Catholic Hospital in Agroyesum in the Amansie West district of the Ashanti region of Ghana. Seventy percent of the cases were children (up to 15 years of age). There was no sex difference in the distribution of cases. Hospitalization was prolonged (average ϭ 186 days in 1994, 103 days in 1995, and 102 days in 1996) with no significant age and sex differences. There were 10 limb amputations, 12 patients were left with contracture deformities, one patient lost sight in one eye, and two died of sepsis and tetanus. The average total treatment cost per patient was $966.85 (62% indirect) in 1994, $706.08 (75% indirect) in 1995, and $658.74 (79% indirect) in 1996. With increasing number of cases, high treatment costs, and serious complications, urgent attention should be given to the disease in terms of control and research efforts aimed at early detection and treatment.

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“…4,5,8 Children were predominantly affected. Hospitalization was prolonged, reflecting the severity of cases at the time of presentation.…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Socioeconomic implications of Buruli ulcer in Ghana: a three-year review.

Asiedu¹,

Etuaful²

1998

The American Journal of Tropical Medicine and Hygiene

186

183

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“…Although the distribution of the disease is global and affects people of all ages, the burden of disease is most severe in West Africa, where Buruli ulcer is an emerging disease. In West Africa, cases typically occur among rural, economically deprived populations (11,31). M. ulcerans is an environmental pathogen; however, the method of transmission from the environment to humans remains elusive (5,11,32).…”

mentioning

confidence: 99%

Persistent Association of Mycobacterium ulcerans with West African Predaceous Insects of the Family Belostomatidae

Mosi

Williamson

Wallace

et al. 2008

Appl Environ Microbiol

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A number of studies have suggested that Mycobacterium ulcerans, the etiological agent of Buruli ulcer, may be transmitted to humans by insect bites. M. ulcerans has been isolated from a predaceous aquatic insect, and PCR detection of M. ulcerans DNA in aquatic environments suggests that the organism is widely distributed within many invertebrate taxa and functional feeding groups. Thus, M. ulcerans may be concentrated through different trophic links. However, the specific environmental niche of M. ulcerans and route of transmission to humans remain a mystery. In this study, a biologically relevant infection model in which M. ulcerans-infected mosquito larvae were fed to a species of predaceous hemiptera (African Belostomatidae) was used to demonstrate the persistent colonization of M. ulcerans and subsequent transmission of bacteria to naïve prey. The association of M. ulcerans with specific anatomical compartments showed that M. ulcerans accumulates preferentially on the exoskeleton. In contrast, few organisms were found in dissected guts or salivary glands. No difference was found between the ability of wild-type M. ulcerans and an M. ulcerans isogenic mycolactonenegative mutant to colonize belostomatids. These data show that African belostomatids can successfully be colonized by M. ulcerans and support the trophic transfer of M. ulcerans within the environment.

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“…6,[8][9][10] Indeed, in endemic areas, a presumptive diagnosis based on the appearance of the lesion and the presence of acid-fast bacilli in exudates is relatively straightforward. However, the diagnosis can be greatly delayed in areas where the disease is not well known.…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium ulcerans infection (Buruli ulcer): first reported case in a traveler.

Semret

Koromihis²,

MacLean³

et al. 1999

The American Journal of Tropical Medicine and Hygiene

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Abstract. A chronic, painless sore developed over a 2-month period on the left calf of a Canadian man traveling for 8 months in Africa. A presumptive diagnosis of a Mycobacterium spp. infection was made despite initially negative biopsy and culture results, after failure of several courses of anti-bacterial antibiotics. Mycobacterium ulcerans was eventually isolated and the lesion progressed despite treatment with multiple anti-mycobacterial agents. The lesion finally responded to wide and repeated excision, aggressive treatment with anti-mycobacterial antibiotics, and splitthickness skin grafting. The isolation and treatment of this unusual organism are discussed.In 1897, Sir Albert Cook described a range of unusual and chronic necrotizing skin ulcers in Africans.

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Mycobacterium ulcerans infection in Ashanti region, Ghana

Cited by 71 publications

References 18 publications

Socioeconomic implications of Buruli ulcer in Ghana: a three-year review.

Socioeconomic implications of Buruli ulcer in Ghana: a three-year review.

Persistent Association of Mycobacterium ulcerans with West African Predaceous Insects of the Family Belostomatidae

Mycobacterium ulcerans infection (Buruli ulcer): first reported case in a traveler.

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