Mycobacterium ulcerans and Buruli Ulcer

Benbow, M. Eric; Hall, Belinda S.; Mosi, Lydia; Roberts, Sophie; Simmonds, Rachel E.; Jordan, Heather Williamson

doi:10.1002/9781118644843.ch44

Cited by 1 publication

(1 citation statement)

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“…Despite this basic understanding, transmission mechanisms have not yet been resolved. M. ulcerans has a doubling time between 24 and 84 h, depending on laboratory conditions, and growth can take months, making culture difficult [ 17 , 18 ]. This limitation contributes to narrow understanding of MU genetic variability in natural environmental populations.…”

Section: Introductionmentioning

confidence: 99%

Linking the Mycobacterium ulcerans environment to Buruli ulcer disease: Progress and challenges

2021

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Buruli ulcer (BU), the second most common mycobacterial disease in West Africa, is a necrotizing skin disease that can lead to high morbidity in affected patients. The disease is caused by Mycobacterium ulcerans (MU), whose major virulence factor is mycolactone. Although early infection can be treated with antibiotics, an effective preventative strategy is challenging due to unknown reservoir(s) and unresolved mode(s) of transmission. Further, disease occurrence in remote locations with limited access to health facilities further complicates disease burden and associated costs. We discuss here MU transmission hypotheses and investigations into environmental reservoirs and discuss successes and challenges of studying MU and Buruli ulcer across human, animal, and environmental interfaces. We argue that a One Health approach is needed to advance the understanding of MU transmission and designing management scenarios that prevent and respond to epidemics. Although previous work has provided significant insights into risk factors, epidemiology and clinical perspectives of disease, understanding the bacterial ecology, environmental niches and role of mycolactone in natural environments and during infection of the human host remains equally important to better understanding and preventing this mysterious disease.

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Section: Introductionmentioning

confidence: 99%