Mycobacterium tuberculosis spoligotypes circulating in the Syrian population: A retrospective study

Abstract

A more inclusive study of the Syrian population is necessary to more accurately identify most of the prevailing families in the country.

Spoligotyping of Mycobacterium tuberculosis isolates using Luminex®-based method in Lebanon

“…The L4 genotype SIT53 by its ubiquitous characteristics, is definitively associated to more than one sublineage although it is also encompassed in L4.1.1 Ghana [16]. It showed a low prevalence (2%) in our study compared to earlier study from Lebanon (20%) [18], as well as to those reported from Egypt (33.8%) [35], Syria (31.3%) [33], Iraq (26.8%) [27], Iran (6.1%) [25], Algeria (25.3%) [36], Tunisia (10.5%) [37], and Italy (11.7%) [38]. This difference in prevalence between our results and others could be attributed to the low number of MTB isolates screened in this study.…”

“…Generally, the CAS sublineages displayed more diverse spoligotypes, SIT25 and SIT26 being the most predominant ones, which might be linked to a yet undeciphered evolutionary dynamics of the L3 within the MTB isolates [31]. A high prevalence of CAS1-Delhi is indeed observed in Sudan (53.9%, SIT25 (35%) [32], Iraq (41.8%; SIT25 (14.2%), SIT26 (6%)) [27], Syria (10.4%; SIT25 and SIT26 (20%)) [33], and Pakistan (CAS 39%; SIT26 39%) [34].…”

Drug-Resistant Tuberculosis and Lines of Mycobacterium Tuberculosis Circulating in Kinshasa

“…Considering other countries outside Africa, we note that the proportion of 43.7% is like those of 40.6% and 43.6% found respectively in Chile and Syria [24,25]. Generally, this LAM family is the largest in Venezuela (65%), in the Mediterranean basin (for example, 34% in Algeria, 55% in Morocco, 30% in Spain) and in the Caribbean region (30%) [25,26].…”