Mycobacterium tuberculosis infection: a rare late complication after cord blood hematopoietic SCT

Assis, Reijane Alves de; Kerbauy, Fábio R.; Rodrigues, Morgani; Seguro, Fernanda Salles; Aranha, LF; Fayad, Luis; Shpall, Elizabeth J.; Lima, Marcos de; Hamerschlak, Nelson

doi:10.1038/bmt.2008.379

Cited by 13 publications

(13 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The incidence of M. tuberculosis infections in recipients of HSCT varies considerably according to the type of HSCT and to the geographical location (1, 14, 21, 23, 26–30). The prevalence of M. tuberculosis infections is higher in recipients of solid organ transplant (SOT) than in HSCT presumably due to the longer immunosuppression in SOT recipients (15, 28, 31, 32).…”

Section: Tuberculosis Infections In Recipients Of Hsctmentioning

confidence: 99%

“…In countries, such as Spain and Turkey, the incidence M. tuberculosis was 1.6% while in Taiwan and Hong Kong, it was 8.57%. The vast majority of M. tuberculosis infections have been reported from Asia and the incidence of TB in recipients of allogeneic HSCT is directly proportional to the incidence of TB in the general population (1, 14, 21, 23, 26–29). Approximately 95% of TB infections in allogeneic HSCT patients have been reported from developing countries, where HSCT is infrequently performed, while the incidence of M. tuberculosis infections in allograft recipients is low in developed countries where HSCT is often performed.…”

Section: Tuberculosis Infections In Recipients Of Hsctmentioning

confidence: 99%

“…M. tuberculosis infections have been reported in various forms of HSCT (5, 16, 19, 26, 29, 32, 41–44). The exact incidence of M. tuberculosis infections among recipients of umbilical cord blood transplant (UCBT) is unknown (16, 26, 41).…”

Section: Tuberculosis Infections In Recipients Of Hsctmentioning

confidence: 99%

“…The exact incidence of M. tuberculosis infections among recipients of umbilical cord blood transplant (UCBT) is unknown (16, 26, 41). The interval between UCBT and the diagnosis of TB infection varies considerably from as early as 21 days to as late as 3 years post-transplant.…”

Section: Tuberculosis Infections In Recipients Of Hsctmentioning

confidence: 99%

See 3 more Smart Citations

Infections Caused by Mycobacterium tuberculosis in Recipients of Hematopoietic Stem Cell Transplantation

2014

View full text Add to dashboard Cite

Mycobacterium tuberculosis (M. tuberculosis) infections are uncommon in recipients of hematopoietic stem cell transplantation. These infections are 10–40 times commoner in recipients of stem cell transplantation than in the general population but they are 10 times less in stem cell transplantation recipients compared to solid organ transplant recipients. The incidence of M. tuberculosis infections in recipients of allogeneic stem cell transplantation ranges between <1 and 16% and varies considerably according to the type of transplant and the geographical location. Approximately 80% of M. tuberculosis infections in stem cell transplant recipients have been reported in patients receiving allografts. Several risk factors predispose to M. tuberculosis infections in recipients of hematopoietic stem cell transplantation and these are related to the underlying medical condition and its treatment, the pre-transplant conditioning therapies in addition to the transplant procedure and its own complications. These infections can develop as early as day 11 and as late as day 3337 post-transplant. The course may become rapidly progressive and the patient may develop life-threatening complications. The diagnosis of M. tuberculosis infections in stem cell transplant recipients is usually made on clinical grounds, cultures obtained from clinical specimens, tissues biopsies in addition to serology and molecular tests. Unfortunately, a definitive diagnosis of M. tuberculosis infections in these patients may occasionally be difficult to be established. However, M. tuberculosis infections in transplant recipients usually respond well to treatment with anti-tuberculosis agents provided the diagnosis is made early. A high index of suspicion should be maintained in recipients of stem cell transplantation living in endemic areas and presenting with compatible clinical and radiological manifestations. High mortality rates are associated with infections caused by multidrug-resistant strains, miliary or disseminated infections, and delayed initiation of therapy. In recipients of hematopoietic stem cell transplantation, isoniazid prophylaxis has specific indications and bacillus Calmette-Guerin vaccination is contraindicated as it may lead to disseminated infection. The finding that M. tuberculosis may maintain long-term intracellular viability in human bone marrow-derived mesenchymal stem cells complicates the development of effective vaccines and strategies to eliminate tuberculosis. However, the introduction of linezolid, cellular immunotherapy, and immunomodulation in addition to autologous mesenchymal stem cell transplantation will ultimately have a positive impact on the overall management of infections caused by M. tuberculosis.

show abstract

Section: Tuberculosis Infections In Recipients Of Hsctmentioning

confidence: 99%

Section: Tuberculosis Infections In Recipients Of Hsctmentioning

confidence: 99%

Section: Tuberculosis Infections In Recipients Of Hsctmentioning

confidence: 99%

Section: Tuberculosis Infections In Recipients Of Hsctmentioning

confidence: 99%

See 2 more Smart Citations

Infections Caused by Mycobacterium tuberculosis in Recipients of Hematopoietic Stem Cell Transplantation

2014

View full text Add to dashboard Cite

show abstract

“…Only seven patients were identified (Table 1, including the patient presented here, labeled as 'Patient 6'). Except for 'Patient 7', who was diagnosed with localized TB more than 4 years post transplant and was off immuno-suppressive drug therapy, 9 TB presented in disseminated form and occurred within the first 100 days after cord blood transplantation (median onset of~50 days post transplant) in other patients. In addition, the mortality rate was extremely high in five out of six cases.…”

mentioning

confidence: 99%

Tuberculosis in umbilical cord blood transplant recipients: clinical characteristics and challenges

Zhang

Mošunjac

Moon

et al. 2015

Bone Marrow Transplant

View full text Add to dashboard Cite

Molecular Methods for Detection of Invasive Fungal Infections and Mycobacteria and Their Clinical Significance in Hematopoietic Stem Cell Transplantation

Yurdakul

Çolakoğlu

2013

Methods in Molecular Biology

View full text Add to dashboard Cite

Infection remains an important source of morbidity and mortality in patients who undergo hematopoietic stem cell transplantation (HSCT). In the immune reconstitution period after transplantation, HSCT recipients are most likely to have bacterial or fungal infections. Invasive fungal infections (IFIs) and mycobacterial infections (MBIs) are among the complications of HSCT, with high morbidity and mortality rates. Early diagnosis of both is crucial in order to manipulate the disease and to avoid fulminant outcomes. This chapter reviews the current knowledge on the molecular diagnosis of IFIs and MBIs in HSCT recipients, describing two different polymerase chain reaction (PCR)-based methods, one commercial (qPCR, Roche) and one in-house IS6110-based protocol.

show abstract

Mycobacterium tuberculosis infection: a rare late complication after cord blood hematopoietic SCT

Cited by 13 publications

References 10 publications

Infections Caused by Mycobacterium tuberculosis in Recipients of Hematopoietic Stem Cell Transplantation

Infections Caused by Mycobacterium tuberculosis in Recipients of Hematopoietic Stem Cell Transplantation

Tuberculosis in umbilical cord blood transplant recipients: clinical characteristics and challenges

Molecular Methods for Detection of Invasive Fungal Infections and Mycobacteria and Their Clinical Significance in Hematopoietic Stem Cell Transplantation

Contact Info

Product

Resources

About