Mycobacterium tuberculosis DNA in erythema induratum of Bazin

Detection of mycobacterial DNA in papulonecrotic tuberculid lesions by polymerase chain reaction

“…Mucosal and orificial tuberculosis has been well described as have been the chronic forms of cutaneous tuberculosis; but less clear are the relationships between the cutaneous tuberculids and the presence of M. tuberculosis within these skin lesions. The subject has been a controversial one because micobacterial DNA has never been cultured from lesions (15)(16)(17). The availability of newer molecular diagnostic techniques permits examination into the cause of these poorly defined lesions and such techniques can also be applied to archival tissues (18).…”

Detection of Mycobacterium tuberculosis DNA in Lobular Granulomatous Panniculitis (Erythema Induratum-Nodular Vasculitis)

“…patients reactive to PPD. [35][36] False-positive results can prob¬ ably be excluded, since canonical precautions to avoid con¬ tamination were taken and appropriate negative controls were used. On the other hand, only 1 patient who was not reactive to PPD had a PCR-positive biopsy specimen, which may represent a true false-positive result.…”

Vasculitis in erythema induratum of Bazin: A histopathologic study of 101 biopsy specimens from 86 patients

“…12 Although the frequency varies from some geographic areas to others, in many countries tuberculosis is still the main causative factor for erythema induratum of Bazin. [13][14][15][16][17][18][19][20] In contrast, in those countries with low prevalence of tuberculosis, this type of panniculitis may be a reactive process as a result of other causative factors such as obesity, cold climate, chronic venous insufficiency, or history of thrombophlebitis of the lower limbs.…”