Mycobacterium tuberculosis burden, multidrug resistance pattern, and associated risk factors among presumptive extrapulmonary tuberculosis cases at Dessie Referral Hospital, Northeast Ethiopia

Tedla, Endalkachew; Ayalew, Getnet

doi:10.4103/ejcdt.ejcdt_49_19

Cited by 3 publications

(9 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of the total of 20 articles reviewed, eight studies were undertaken in the Amhara region [ 15 – 22 ], four studies in Addis Ababa [ 23 – 26 ], four in Oromia [ 27 – 30 ], one study in the Southern Nations Nationalities and People Region [ 31 ], and the remaining three studies were based on data collected from different regions of the country [ 32 – 34 ]. The data collection period ranges from 1998 [ 31 ] to 2020 [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

“…Fourteen studies only examined one type of sample, while the remaining six studies reported evaluating various sample types. Regarding diagnostic methods, five studies used smear microscopy and culture methods [ 26 , 29 , 32 – 34 ], three studies used smear microscopy, culture, and Xpert MTB/RIF assay [ 15 , 25 , 28 ], two studies applied smear microscopy [ 16 , 31 ], two studies used the Xpert MTB/RIF assay [ 20 , 22 ], two studies used the culture and Xpert MTB/RIF assay [ 19 , 30 ], one study used the Xpert MTB/RIF and microscopy [ 21 ], and the remaining five studies used the culture [ 17 , 18 , 23 , 24 , 27 ] ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…The impact of each study on the overall meta-analysis summary estimate was investigated. A history of PTB infection and contact with PTB patients was found to be significant risk factors for EPTB incidence in the majority of investigations [ 15 , 16 , 19 – 22 ]. Furthermore, having regular and direct contact with live animals, as well as the consumption of raw milk, were found to be strongly related to the incidence of EPTB [ 16 , 34 ].…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, having regular and direct contact with live animals, as well as the consumption of raw milk, were found to be strongly related to the incidence of EPTB [ 16 , 34 ]. Additionally, being HIV-positive [ 19 , 20 , 22 ], ages <14 [ 15 ], age 41–50 [ 20 ], being male [ 15 , 20 ], monthly less income [ 16 ], urban [ 15 ] were all linked to the most common EPTB.…”

Section: Resultsmentioning

confidence: 99%

“…In this current systematic review and meta-analysis investigation, HIV-1 infected patients were the most significant risk factors for EPTB infection [ 19 , 20 , 22 ]. Similarly, several studies have examined the association between HIV-1 infection and EPTB infection [ 6 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Bacteriologically confirmed extrapulmonary tuberculosis and the associated risk factors among extrapulmonary tuberculosis suspected patients in Ethiopia: A systematic review and meta-analysis

Diriba

Alemu

Eshetu³

et al. 2022

PLoS ONE

View full text Add to dashboard Cite

Background The actual burden of bacteriologically confirmed extrapulmonary tuberculosis (EPTB) and risk factors in Ethiopia is not well known due to the lack of a strong surveillance system in Ethiopia. Thus, this study was conducted to estimate the pooled prevalence of bacteriologically confirmed EPTB and the associated risk factors among persons suspected to have non-respiratory tuberculosis in Ethiopia. Methods A systematic review and meta-analysis of published studies reporting the prevalence of EPTB from searched electronic databases; Science Direct, PubMed, and Google Scholar was estimated spread across the research periods, nationally, and in different areas, using a fixed-effects model. We used I2 to analyze heterogeneity in the reported prevalence of bacteriologically confirmed extrapulmonary tuberculosis. Results After reviewing 938 research articles, 20 studies (19 cross-sectional and 1 retrospective) from 2003 to 2021 were included in the final analyses. The pooled prevalence of bacteriologically confirmed EPTB was 43% (95%CI; 0.34–0.52, I2 = 98.45%). The asymmetry of the funnel plot revealed the presence of publication bias. Specifically the pooled prevalence of bacteriologically confirmed EPTB based on smear microscopy, Xpert MTB/RIF assay, and culture were 22% (95%CI; 0.13–0.30, I2 = 98.56%), 39% (95%CI; 0.23–0.54, I2 = 98.73%) and 49% (95%CI; 0.41–0.57, I2 = 96.43%) respectively. In this study, a history of pulmonary tuberculosis (PTB) contact with PTB patients, contact with live animals, consumption of raw milk, HIV-positive, male, and lower monthly income, were found to be independently associated with bacteriologically confirmed EPTB. Conclusion Ethiopia has a high rate of bacteriologically confirmed EPTB. A history of previous PTB, being HIV-positive and having contact with PTB patients were the most reported risk factors for EPTB in the majority of studies. Strengthening laboratory services for EPTB diagnosis should be given priority to diagnose EPTB cases as early as possible.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Bacteriologically confirmed extrapulmonary tuberculosis and the associated risk factors among extrapulmonary tuberculosis suspected patients in Ethiopia: A systematic review and meta-analysis

Diriba

Alemu

Eshetu³

et al. 2022

PLoS ONE

View full text Add to dashboard Cite

show abstract

Burden of Mycobacterium tuberculosis and Associated Factors among Presumptive Extra pulmonary Tuberculosis Patients from Selected Health Facilities, Addis Ababa, Ethiopia

Alehegn¹,

Gebreyohannes²,

Berhane³

et al. 2023

IJID Regions

View full text Add to dashboard Cite

The Burden of Bacteriologically Negative TB Diagnosis: A Four-Year Review of Tuberculosis Cases at a Tertiary Facility

Afriyie-Mensah,

Aryee,

Zigah

et al. 2023

Tuberculosis Research and Treatment

View full text Add to dashboard Cite

Aim. We aimed to investigate the demographic and clinical factors associated with TB mortality in patients managed at a tertiary TB referral center. Methods. We conducted a retrospective review of the medical records of 1,933 TB patients seen between January 2017 and December 2020 at the Korle-Bu Teaching Hospital (KBTH) Chest Department in Accra, Ghana. TB mortality was defined as any TB patient who died for any reason during the course of treatment. Multivariable logistic regression was used to estimate adjusted odds ratios with 95% confidence intervals for factors associated with TB mortality. Results. A total of 1,933 patients with TB were registered at the chest clinic over the study period. Males accounted for 1,227 (63.5%), and majority of participants were between 24 and 64 years old. Pulmonary TB (PTB) and extrapulmonary TB (EPTB) cases accounted for 51% and 48.4% of the total TB cases, respectively. A significant proportion (69%) of the patients managed for TB had no bacteriological confirmation of the disease. About 34% of tested TB patients were HIV positive. Mortality among patients was 33.6%. In a multivariable regression model, patients with HIV positive status had over 3-fold increased risk of mortality, compared to those with HIV negative status. TB patients diagnosed empirically had an increased risk of death compared to those with a confirmed diagnosis. Conclusion. The proportion of clinically diagnosed TB was high among the patients seen at the chest clinic. Mortality was high among the patients with HIV/TB coinfection as well as in patients with empirical TB diagnosis.

show abstract

Mycobacterium tuberculosis burden, multidrug resistance pattern, and associated risk factors among presumptive extrapulmonary tuberculosis cases at Dessie Referral Hospital, Northeast Ethiopia

Cited by 3 publications

References 10 publications

Bacteriologically confirmed extrapulmonary tuberculosis and the associated risk factors among extrapulmonary tuberculosis suspected patients in Ethiopia: A systematic review and meta-analysis

Bacteriologically confirmed extrapulmonary tuberculosis and the associated risk factors among extrapulmonary tuberculosis suspected patients in Ethiopia: A systematic review and meta-analysis

Burden of Mycobacterium tuberculosis and Associated Factors among Presumptive Extra pulmonary Tuberculosis Patients from Selected Health Facilities, Addis Ababa, Ethiopia

The Burden of Bacteriologically Negative TB Diagnosis: A Four-Year Review of Tuberculosis Cases at a Tertiary Facility

Contact Info

Product

Resources

About