Mycobacterium thermoresistible Recovered from a Cutaneous Lesion in an Otherwise Healthy Individual

Cummings, George H.; Natarajan, Sridhar; DeWitt, Caroline C.; Gardner, Timothy L.; Garces, Maria C.

doi:10.1086/314020

Cited by 6 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[14,15] Moreover, the currently available commercial diagnostic kits do not include species-specific probes for M. thermoresistibile. [17] One of the greatest difficulties concerning NTM is whether the isolation of an NTM is merely colonization or cause of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…A modification of the proportional susceptibility test was suggested by the authors. Their antimicrobial test showed susceptibility to AN, CIP, DOX, RMP, ETH, STR, caproemycin and tetracycline and resistance to ETN, PAS, INH and OFL.A coinfection of M. thermoresistibile and M. fortuitum was described by Cummings et al [15] It concerned a patient with a slowly expanded cutaneous lesion developed after an injury with garden shears. Identification was achieved with high-pressure liquid chromatography (HPLC).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Mycobacterium Thermoresistibile: Case Report of a Rarely Isolated Mycobacterium From Europe and Review of Literature

Neonakis

Gitti

Kontos

et al. 2009

Indian Journal of Medical Microbiology

View full text Add to dashboard Cite

Mycobacterium thermoresistibile is a non-tuberculous mycobacterium strongly associated with human infections. Since 1966, there have only been six reports of its isolation from clinical samples. We report on the first case from Europe and review all the previous cases. Identification was achieved with sequencing of the 16S rRNA and hsp65 genes. This study presents its phenotypic and biochemical profile, susceptibilities to selected antibiotics and hsp65 polymerase chain reaction-restriction fragment length polymorphism profile with BsteII and Hae III. Key words: hsp65, Mycobacterium thermoresistibile, nontuberculous mycobacteriaAlthough Mycobacterium tuberculosis is responsible for majority of the mycobacterial infections worldwide, many non-tuberculous mycobacteria (NTM) are also of medical relevance. Over the past four decades, more than 120 mycobacterial species have been described. A growing number of NTM isolates, often of newly described species, are submitted to laboratories for identification.[1] Members of the M. avium complex, M. chelonae, M. abscessus, M. fortuitum, M. kansasii and M. xenopi, have been considered responsible for most of the NTM infections like pulmonary diseases, lymphadenopathy and skin and soft tissue lesions. Among NTM, rapidly growing mycobacteria (RGM) are those which show visible growth on solid culture media within seven days.M. thermoresistibile is an RGM that was first recovered from soil samples in Japan by Tsukamura in 1966. [2] Of the commonly known species, it is closely related to M. phlei and, as its name points out, has the ability to grow at 52°C. M. thermoresistibile has been strongly related with human infections. [3,4] However, it is rarely isolated. Since 1966, there have been only six reports of M. thermoresistibile isolations from human clinical samples.We report on the isolation of M. thermoresistibile from a sputum culture of a patient from the island of Crete, Greece, with chronic obstructive pulmonary disease (COPD), diabetes and purpura. To our knowledge, this is the first report of M. thermoresistibile isolation from clinical samples in Europe. Identification was achieved with sequencing. Its biochemical profile and susceptibilities to selected antibiotics are reported and a concise review of previous cases is presented. The polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) profile of hsp65 using BstEII and HaeIII is also presented. Case ReportA 67-year-old male, human immunodeficiency virus negative, who was a heavy smoker (one pack/day for 30 years) and had a history of COPD, type II respiratory distress syndrome, diverticulosis and diabetes was presented to our hospital with fever (38 o C), productive cough, dyspnea, weakness and acute purpura. The chest radiograph revealed an elevated cardiothoracic ratio as well as chronic obstructive lung disease, peribronchial infiltrations, consolidations in the right middle and lower lung zones and a small blunt at the left pneumodiaphragmatic angle. The Mantoux test was positive (30 ...

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Mycobacterium Thermoresistibile: Case Report of a Rarely Isolated Mycobacterium From Europe and Review of Literature

Neonakis

Gitti

Kontos

et al. 2009

Indian Journal of Medical Microbiology

View full text Add to dashboard Cite

show abstract

A case of severe Mycobacterium thermoresistibile pneumonia

Subramaniam,

Kanhere,

Shephard

et al. 2024

Respirology Case Reports

View full text Add to dashboard Cite

Mycobacterium thermoresistibile is a thermotolerant nontuberculous mycobacterium which can rarely result in human infection. Although immunosuppression has been identified as a risk factor for infection, it is possible that mycobacterial laboratories may have previously under‐recognized M. thermoresistibile as standard mycobacterial incubation temperatures are suboptimal for culture of this organism. Here, we present a case of severe M. thermoresistibile pneumonia associated with achalasia requiring life support in the intensive care unit. We speculated that the interplay between specific host and environmental risk factors contributed to acquisition of infection. Infection with this fastidious organism required prolonged treatment with multiple antimicrobials and adjunctive therapeutic drug monitoring which led to clinical cure despite residual lung injury. We also reviewed literature documenting cases of human infection with M. thermoresistibile. The diagnosis of M. thermoresistibile requires a high degree of clinical suspicion considering its association with immunosuppressive conditions, postulated environmental inoculation and eponymous culture growth characteristics.

show abstract

Environments Providing Favourable Conditions for the Multiplication and Transmission of Mycobacteria

Pavlík

Falkinham

Kazda

2009

The Ecology of Mycobacteria: Impact on Animal's and Human's Health

View full text Add to dashboard Cite

Mycobacterium thermoresistible Recovered from a Cutaneous Lesion in an Otherwise Healthy Individual

Abstract: This is the first report of coinfection by Mycobacterium thermoresistible and Mycobacterium fortuitum and only the fifth case of human infection by M. thermoresistible reported in the world literature.

Cited by 6 publications

References 5 publications

Mycobacterium Thermoresistibile: Case Report of a Rarely Isolated Mycobacterium From Europe and Review of Literature

Mycobacterium Thermoresistibile: Case Report of a Rarely Isolated Mycobacterium From Europe and Review of Literature

A case of severe Mycobacterium thermoresistibile pneumonia

Environments Providing Favourable Conditions for the Multiplication and Transmission of Mycobacteria

Contact Info

Product

Resources

About