Mycobacterium species on the cutaneous microbiome of very preterm neonates admitted to the NICU in a tertiary health care hospital

Shah, Pritik A; Govindarajan, Varun; Rangaiah, Ambica; Diggikar, Shivashankar; Devadas, Sahana; Chunchanur, Sneha K; Shankar, Sathyanarayan Muthur; Kariyappa, Mallesh

doi:10.1016/j.ijantimicag.2021.106421.152

Cited by 2 publications

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“…Colonization by Candida species in high abundance increases the risk of candidaemia according to previous studies, though none of our babies had any invasive fungal sepsis. 5,6 One baby died due to multi-organ dysfunction secondary to bacterial sepsis. The mere presence of these species in premature babies is alarming for the treating physician concerned about the possible hazards of invasive fungal sepsis, cross-infection, and outbreaks.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Skin Mycobiome in Very Preterm babies during the early neonatal period in a Neonatal Intensive Care Unit of India

Shah

Govindarajan

Diggikar³

et al. 2022

Trop Doct

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The neonatal skin microbiome consists of all the genomes and genetic products of micro-organisms harbouring the skin of babies. Host and the microbiota develop a harmonious environment resulting in symbiosis. Any disruption of this environment could lead to pathological disease. Our study was conducted to explore the neonatal skin fungal microbiome of very preterm neonates admitted to Neonatal Intensive Care Unit at a tertiary health care setting using Next Generation Sequencing of the18S rRNA gene. The most abundant genera found in 22/30 samples were Candida followed by Bipolaris & Cladosporium on the skin microbiome of these neonates. The presence of these fungi, whether just as commensals or as potential pathogens, is currently under research, owing to the risk of early exposure and incidence of infection right from birth.

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Section: Discussionmentioning

confidence: 99%

Exploring the Skin Mycobiome in Very Preterm babies during the early neonatal period in a Neonatal Intensive Care Unit of India

Shah

Govindarajan

Diggikar³

et al. 2022

Trop Doct

Self Cite

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Mycobacterium Species on the Cutaneous Microbiome of Very Preterm Neonates

Shah

Govindarajan

Rangaiah

et al. 2022

Journal of Tropical Pediatrics

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The neonatal skin microbiome consists of all the genomes and genetic products of microorganisms harboring on an infant’s skin. Host and the microbiota develop a harmonious environment resulting in symbiosis. Any disruption of this environment could lead to pathological disease. This study was conducted to understand the neonatal skin microbiome of very preterm neonates (under 32 weeks) admitted to the Neonatal Intensive Care Unit(NICU) at a tertiary healthcare setting before and after kangaroo mother care (KMC), using next-generation sequencing (NGS). Skin swabs were collected on two different occasions and analyzed using the NGS technique after amplification via polymerase chain reaction. The results showed relative abundance for Mycobacterium tuberculosis in 83.33% and 66.67% (p = 0.29) and Mycobacteroides abscessus in 100% and 93.33% (p = 0.30) of the very preterm neonates on the skin microbiome before and after KMC, respectively as an incidental finding. The mere presence of these bacilli as commensals or as potential pathogens is alarming due to the risk of early exposure and incidence of tuberculosis from birth. These findings, in our view, are the first findings to be established in such a setting.

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Mycobacterium species on the cutaneous microbiome of very preterm neonates admitted to the NICU in a tertiary health care hospital

Cited by 2 publications

References 0 publications

Exploring the Skin Mycobiome in Very Preterm babies during the early neonatal period in a Neonatal Intensive Care Unit of India

Exploring the Skin Mycobiome in Very Preterm babies during the early neonatal period in a Neonatal Intensive Care Unit of India

Mycobacterium Species on the Cutaneous Microbiome of Very Preterm Neonates

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