Mycobacterium microti Infection in Two Meerkats (Suricata suricatta)

Palgrave, Christopher J; Benato, Livia; Eatwell, Kevin; Laurenson, Ian F.; Smith, Noel H.

doi:10.1016/j.jcpa.2011.06.001

Cited by 17 publications

(9 citation statements)

References 28 publications

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“…Indeed, field voles (Microtus agrestis), bank voles (Myodes glareolus), wood mice (Apodemus sylvaticus), and shrews (Sorex araneus), which are particularly susceptible to M. microti infection, constitute its natural reservoirs (1). However, an increasing number of cases have also been reported in domestic and wild mammals (2), such as cats (3,4), pigs (5), European wild boar (Sus scrofa) (6), ferrets (Mustela putorius), badgers (Meles meles) (4), New World camelids (Lama glama and Vicugna pacos) (4), squirrel monkeys (Saimiri sciureus) (7), meerkats (Suricata suricatta) (8), and a dog (9). Until now, 27 cases of M. microti infection in both immunocompetent (10) and immunocompromised human patients (11) have been described (12), demonstrating its capacity for causing clinical illness and thus for being a potential zoonotic agent.…”

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confidence: 99%

Infection with Mycobacterium microti in Animals in France

et al. 2015

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confidence: 99%

Infection with Mycobacterium microti in Animals in France

et al. 2015

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“…Occasionally, it was also found in llamas, cats, pigs, cows, and dogs (3,(6)(7)(8)(9)(10)(11)(12)(13). Recently, the widespread host range of M. microti seemed to be increasing, with reports of an infected cat population in England (9,14,15) and with accounts of new hosts, such as squirrel monkeys (16), meerkats (17), and South American camelids (18). In humans, infection by M. microti is infrequent, and to date only 27 cases have been reported in immunosuppressed and/or immunocompetent patients (19)(20)(21)(22)(23).…”

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Detection and Molecular Characterization of Mycobacterium microti Isolates in Wild Boar from Northern Italy

et al. 2014

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Approximately 23,000 hunter-harvested wild boars from the pre-Alpine area of northern Italy were examined for tuberculosis over a 9-year period (2003 to 2011). Retropharyngeal and mandibular lymph nodes from the wild boars were examined grossly, and 1,151 of the lymph nodes were analyzed in our laboratory by histology (728 samples) and culture isolation (819 samples). Mycobacterium tuberculosis complex (MTBC)-specific PCR (1,142 samples) was used for molecular-level detection in tissue samples, as was a gyrB restriction fragment length polymorphism (RFLP) assay (322 samples). Lesions compatible with tuberculosis and indistinguishable from those described in cases of Mycobacterium bovis infection had been observed since 2003. Mycobacterium microti was identified directly in 256 tissue samples by the adopted molecular approaches. However, only 26 M. microti strains were obtained by culture isolation due to the well-known difficulties in isolating this slow-growing mycobacterium. During 2006, a prevalence study was performed in two provinces of the area, and the diffusion of M. microti was calculated to be 5.8% (95% confidence intervals surrounding the estimated prevalences [CI P95% ], 3.94 to 7.68%). Over the following years (2007 to 2011), the presence of M. microti appeared to be stable. All isolates were genotyped by spoligotyping and exact tandem repeat analysis (ETR types A to F). In addition to the typical vole type (SB0118), a new spoligotype lacking the 43 spacers was found. Spoligotyping was also applied directly to tissue samples, and a geographical cluster distribution of the two spoligotypes was observed. This is the first report studying the diffusion and genetic variability of M. microti in wild boar.

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“…7,15 Mycobacteriosis, another important zoonotic disease, was recently reported in freeranging and zoo meerkats. 5,16 From public health and treatment perspectives, it is important to differentiate Yersinia spp. from other organisms using immunohistochemistry and bacterial identification.…”

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Yersiniosis due to infection byYersinia pseudotuberculosis4b in captive meerkats (Suricata suricatta) in Japan

et al. 2015

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Two meerkats (Suricata suricatta) housed in the same zoological garden in Japan died due to Yersinia pseudotuberculosis serotype 4b infection. Gross and microscopic lesions included necrotizing enteritis and enlargement of the spleen and liver with multifocal necrosis. Inflammatory cells, primarily neutrophils, and nuclear debris were associated with clusters of Gram-negative bacilli. Additionally, there were aberrant organism forms that were larger than bacilli and appeared as basophilic globular bodies. Immunohistochemical examination showed that the bacilli and globular bodies were strongly positive for Y. pseudotuberculosis O4 antigen. The globular bodies were considered a shape-changed form of Y. pseudotuberculosis, and these morphologically abnormal bacteria could present a diagnostic challenge.

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Mycobacterium microti Infection in Two Meerkats (Suricata suricatta)

Cited by 17 publications

References 28 publications

Infection with Mycobacterium microti in Animals in France

Infection with Mycobacterium microti in Animals in France

Detection and Molecular Characterization of Mycobacterium microti Isolates in Wild Boar from Northern Italy

Yersiniosis due to infection byYersinia pseudotuberculosis4b in captive meerkats (Suricata suricatta) in Japan

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