Mycobacterium malmoense: an easily missed pathogen

Hoffner, Sven; Henriques, Birgitta; Petrini, Björn; Källenius, Gunilla

doi:10.1128/jcm.29.11.2673-2674.1991

Cited by 42 publications

(12 citation statements)

References 8 publications

(7 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such a difference in detection time was described before (23). It is well-known that LJ is not the best medium for the isolation of MOTT isolates, because LJ is designed primarily for the growth of M. tuberculosis and is not reliable for the recovery of other species (10,12,18).…”

Section: Discussionmentioning

confidence: 91%

Comparison of fluorescent BACTEC 9000 MB system, Septi-Chek AFB system, and Lowenstein-Jensen medium for detection of mycobacteria

1996

View full text Add to dashboard Cite

The newly developed fluorescent BACTEC 9000 MB system for automated culture of mycobacteria was compared with the Septi-Chek AFB system and Lowenstein-Jensen medium (LJ). A total of 2,005 clinical specimens were included in the study. Mycobacteria were isolated from 202 (10.1%) specimens, including 155 Mycobacterium tuberculosis complex isolates and 47 Mycobacteria other than M. tuberculosis isolates. Of 131 isolates detected by the BACTEC system, the Septi-Chek AFB system, or both, 120 (91.6%) were detected by the BACTEC system and 105 (80.2%) were detected by the Septi-Chek AFB system (P < 0.02). The recovery rate in the BACTEC system compared with that in the Septi-Chek AFB system was significantly higher for M. tuberculosis complex isolates (P < 0.005) and for isolates from acid-fast smear-negative specimens (P < 0.01). Of 148 isolates detected by the BACTEC system, LJ, or both, 142 (95.9%) were detected by the BACTEC system and 118 (79.9%) were detected by LJ (P < 0.001). The recovery rate in the BACTEC system compared with that on LJ was significantly higher for M. tuberculosis complex isolates (P < 0.001). The BACTEC system detected more mycobacteria from both smear-positive and smear-negative specimens than LJ. The mean times to detection of mycobacteria were 17.6 days for the BACTEC system, 26.0 days for the Septi-Chek AFB system, and 29.4 days for LJ. The BACTEC fluorescent 9000 MB system is a rapid, sensitive, and efficient method for the isolation of mycobacteria.

show abstract

Section: Discussionmentioning

confidence: 91%

Comparison of fluorescent BACTEC 9000 MB system, Septi-Chek AFB system, and Lowenstein-Jensen medium for detection of mycobacteria

1996

View full text Add to dashboard Cite

show abstract

“…Although the number of cases is rather small, the incidence of M. malmoense infections is rising in England (88,257,259,561), Scotland (158), and Scandinavia (269). In Sweden, it is the most common cause of mycobacterial infections after M. tuberculosis and the M. avium complex (222). M. malmoense is the second most frequent cause of lymphadenitis in southeastern England, after the M. avium complex (184).…”

Section: Epidemiology Of M Malmoense Infectionmentioning

confidence: 99%

“…M. malmoense can be easily missed in the laboratory (222). First, M. malmoense requires a longer incubation period than other nontuberculous mycobacteria for colony formation (448).…”

Section: Characteristics Of M Malmoensementioning

confidence: 99%

Epidemiology of infection by nontuberculous mycobacteria

1996

View full text Add to dashboard Cite

“…Mycobacterium malmoense is another atypical mycobacterium which was first described in 1977 [3]. In Scandinavia an increased incidence of isolates has been reported from lymph nodes in children with localized infection and from adults with pulmonary disease [4]. A disseminated infection with M .…”

Section: Introductionmentioning

confidence: 99%

Disseminated Mycobacterium malmoense infection in a patient with chronic granulocytic leukaemia

Engervall

Björkholm

Petrini

et al. 1993

Journal of Internal Medicine

View full text Add to dashboard Cite

Mycobacterium malmoense is an atypical mycobacterium previously isolated from lymph nodes in children and from adults with pulmonary disease. Disseminated infection is extremely rare and bone marrow involvement has never previously been described. We report a patient with chronic granulocytic leukaemia and persistent fever with granuloma in the bone marrow due to disseminated M. malmoense infection. The patient initially received treatment with isoniazid, ethambutol and rifampicin with clearance of mycobacteria in the bone marrow and clinical improvement. Sensitivity in vitro was established for streptomycin, amikacin, ethambutol and rifabutin. The patient eventually expired as a result of progressive respiratory failure from other opportunistic infections. At autopsy staining of samples from lung parenchyma revealed fungal hyphi but staining for Pneumocystis carinii and myobacteria were negative.

show abstract

Mycobacterium malmoense: an easily missed pathogen

Cited by 42 publications

References 8 publications

Comparison of fluorescent BACTEC 9000 MB system, Septi-Chek AFB system, and Lowenstein-Jensen medium for detection of mycobacteria

Comparison of fluorescent BACTEC 9000 MB system, Septi-Chek AFB system, and Lowenstein-Jensen medium for detection of mycobacteria

Epidemiology of infection by nontuberculous mycobacteria

Disseminated Mycobacterium malmoense infection in a patient with chronic granulocytic leukaemia

Contact Info

Product

Resources

About