Mycobacterium celatum sp. nov.

Butler, W. Ray; O'Connor, S P; Yakrus, Mitchell A.; Smithwick, Ronald W.; Plikaytis, Bonnie B.; Moss, C W; Floyd, Margaret M.; Woodley, Charles L.; Kilburn, James O.; VADNEY, F. S.; Gross, W.

doi:10.1099/00207713-43-4-868

Cited by 31 publications

(61 citation statements)

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“…This pattern of mycolic acid subclasses is characteristic for the Mycobacterium avium complex, and is also seen in M. celatum and M. branderi, suggesting that the new isolates are closely related to these Mycobacterium species (Fig. 1) (Butler et al, 1993;Brander et al, 1992).…”

Section: Resultsmentioning

confidence: 99%

“…Among the non-tuberculous mycobacteria, Mycobacterium celatum was first described by Butler et al (1993). It has unique species-specific 16S rRNA and superoxide dismutase sequences, resembling those of Mycobacterium xenopi, but is biochemically indistinguishable from the Mycobacterium avium complex (Butler et al, 1993). Sequencing analysis of the 16S rRNA gene in additional M. celatum strains revealed the existence of a new subtype, which is distinct from but very similar to the two previously reported subtypes (types 1 and 2) (Butler et al, 1993).…”

Section: Introductionmentioning

confidence: 84%

“…It has unique species-specific 16S rRNA and superoxide dismutase sequences, resembling those of Mycobacterium xenopi, but is biochemically indistinguishable from the Mycobacterium avium complex (Butler et al, 1993). Sequencing analysis of the 16S rRNA gene in additional M. celatum strains revealed the existence of a new subtype, which is distinct from but very similar to the two previously reported subtypes (types 1 and 2) (Butler et al, 1993). Furthermore, Mycobacterium branderi was described as a novel species in 1995, and analysis of its 16S rRNA sequence has confirmed the close phylogenetic relationship of this organism to M. celatum (Koukila-Kahkola et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

“…Currently, there are more than 100 species of nontuberculous mycobacteria, of which approximately 60 are considered to be potential pathogens (Brown-Elliott & Wallace, 2005). Among the non-tuberculous mycobacteria, Mycobacterium celatum was first described by Butler et al (1993). It has unique species-specific 16S rRNA and superoxide dismutase sequences, resembling those of Mycobacterium xenopi, but is biochemically indistinguishable from the Mycobacterium avium complex (Butler et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

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Mycobacterium kyorinense sp. nov., a novel, slow-growing species, related to Mycobacterium celatum, isolated from human clinical specimens

Okazaki

Ohkusu

Hata

et al. 2009

INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLO

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Mycobacterium kyorinense sp. nov., a novel, slow-growing species, related to Mycobacterium celatum, isolated from human clinical specimens A novel, non-pigmented, slow-growing mycobacterium was identified on the basis of biochemical and nucleic acid analyses, as well as growth characteristics. Three isolates were cultured from clinical samples (two from sputum and one from pus in lymph nodes) obtained from three immunocompetent patients with infections. Bacterial growth occurred at 28-42 6C on Middlebrook 7H11-OADC agar. The isolates showed negative results for Tween hydrolysis, nitrate reductase, semiquantitative catalase, urease activity, 3 day arylsulfatase activity, pyrazinamidase, tellurite reduction and niacin accumulation tests, but positive results for 14 day arylsulfatase activity and heat-stable catalase tests. The isolates contained a-, keto-, and dicarboxymycolates in their cell walls. Sequence analysis revealed that all isolates had identical, unique 16S rRNA sequences. Phylogenetic analysis of the 16S rRNA, rpoB, hsp65 and sodA gene sequences confirmed that these isolates are unique but closely related to Mycobacterium celatum. DNA-DNA hybridization of the isolates demonstrated less than 50 % reassociation with M. celatum and Mycobacterium branderi. On the basis of these findings, a novel species designated Mycobacterium kyorinense sp. nov. is proposed. The type strain is KUM 060204 T (5JCM 15038 T 5DSM 45166 T ).The GenBank/EMBL/DDBJ accession numbers for the 16S rRNA, hsp65, proB and sodA gene sequences of strains KUM 060204 T , NTH 512-121 and AHM 060905 are, respectively: AB370111, AB370169 and AB370170 (16S rRNA); AB370171, AB370176, and AB370177 (hsp65); AB370178, AB370182, and AB370183 (rpoB); AB370184, AB370188, and AB370189 (sodA).

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mycobacterium kyorinense sp. nov., a novel, slow-growing species, related to Mycobacterium celatum, isolated from human clinical specimens

Okazaki

Ohkusu

Hata

et al. 2009

INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLO

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“…For example, the MA of M.bovis BCG can be distinguished from those of M.tuberculosis and M. bovis [45]. It can also be used to suggest the phylogenetic position of newly isolated mycobacteria [46]. By coupling HPLC to electrospray ionization quadrupole TOF-MS it is possible to provide both qualitative and semi-quantitative analysis of mycolic acids.…”

Section: Structural Properties Of Mycolic Acids Of Mycobacterium Specmentioning

confidence: 99%

Towards understanding the functional diversity of cell wall mycolic acids of Mycobacterium tuberculosis

Verschoor

Baird

Grooten

2012

Progress in Lipid Research

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Mycolic acids constitute the waxy layer of the outer cell wall of Mycobacterium spp and a few other genera. They are diverse in structure, providing a unique chromatographic foot-print for almost each of the more than seventy Mycobacterium species. Although mainly esterified to cell wall arabinogalactan, trehalose or glucose, some free mycolic acid is secreted during in vitro growth of M. tuberculosis. In M. tuberculosis, alpha-, keto-and methoxy-mycolic acids are the main classes, each differing in their ability to attract neutrophils, induce foamy macrophages or adopt an antigenic structure for antibody recognition. Of interest is their particular relationship to cholesterol, discovered by their ability to attract cholesterol, to bind Amphotericin B or to be recognised by monoclonal antibodies that cross-react with cholesterol. The structural elements that determine this diverse functionality include the carboxylic acid in the mycolic motif, as well as the nature and stereochemistry of the two functional groups in the merochain. The functional diversity of mycolic acid classes implies that much information may be contained in the selective expression and secretion of mycolic acids to establish tuberculosis after infection of the host. Their cholesteroid nature may relate to how they utilize host cholesterol for their persistent survival.

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Mycobacterium celatum pulmonary infection mimicking pulmonary tuberculosis in a patient with ankylosing spondylitis

Tan

Lai

Chou

et al. 2009

International Journal of Infectious Diseases

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Mycobacterium celatum, a slow-growing acid-fast bacillus, is an uncommon cause of human infection, mainly occurring in patients with AIDS. Rarely, infections restricted to the lung and lymph nodes have been reported in immunocompetent hosts. We report herein a case of M. celatum pulmonary infection that mimicked pulmonary tuberculosis in a patient with ankylosing spondylitis. The literature was reviewed and clinical features of eight HIV-negative patients with M. celatum infection are discussed. The clinical presentation of M. celatum is indistinguishable from tuberculosis, especially in patients with a previous history of pulmonary tuberculosis. Proper treatment depends on a definitive identification of this pathogen, which requires 16S rDNA sequencing or mycolic acid high performance liquid chromatography analysis.

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Mycobacterium celatum sp. nov.

Cited by 31 publications

References 0 publications

Mycobacterium kyorinense sp. nov., a novel, slow-growing species, related to Mycobacterium celatum, isolated from human clinical specimens

Mycobacterium kyorinense sp. nov., a novel, slow-growing species, related to Mycobacterium celatum, isolated from human clinical specimens

Towards understanding the functional diversity of cell wall mycolic acids of Mycobacterium tuberculosis

Mycobacterium celatum pulmonary infection mimicking pulmonary tuberculosis in a patient with ankylosing spondylitis

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