Mycobacterium avium subsp. paratuberculosis and Crohn’s disease: characterization of the interaction with different aspects of the disease

Espeschit, Isis Freitas; Bastos, Daniel Silva Sena; Fonseca, Ana Carolina Machado da; Cardoso, Sílvia Almeida; Ferrari, Maria Luisa; Moreira, Maria Aparecida Scatamburlo

doi:10.1007/s42770-023-00932-4

Cited by 4 publications

(6 citation statements)

References 31 publications

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“…MAP can survive outside the animal for quite some time. In river waters, it can stay alive for 5 months and in lake waters, it can survive for 9 months [49]. In feces and soil, MAP can survive for 11 months, while in urine, it can only survive for 7 days [50].…”

Section: Morphology and Biological Characteristics Of Mycobacterium A...mentioning

confidence: 99%

“…MAP is transmitted by oral ingestion, mainly in the feces and, to a lesser extent, through contaminated milk and colostrum. The main source of infection for flocks is adult animals at an advanced stage of infection that shed the bacterium in large quantities [49]. In humans, Mycobacterium sp.…”

Section: Morphology and Biological Characteristics Of Mycobacterium A...mentioning

confidence: 99%

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Long Non-Coding RNAs and Their “Discrete” Contribution to IBD and Johne’s Disease—What Stands out in the Current Picture? A Comprehensive Review

Triantaphyllopoulos

2023

IJMS

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Non-coding RNAs (ncRNA) have paved the way to new perspectives on the regulation of gene expression, not only in biology and medicine, but also in associated fields and technologies, ensuring advances in diagnostic means and therapeutic modalities. Critical in this multistep approach are the associations of long non-coding RNA (lncRNA) with diseases and their causal genes in their networks of interactions, gene enrichment and expression analysis, associated pathways, the monitoring of the involved genes and their functional roles during disease progression from one stage to another. Studies have shown that Johne’s Disease (JD), caused by Mycobacterium avium subspecies partuberculosis (MAP), shares common lncRNAs, clinical findings, and other molecular entities with Crohn’s Disease (CD). This has been a subject of vigorous investigation owing to the zoonotic nature of this condition, although results are still inconclusive. In this review, on one hand, the current knowledge of lncRNAs in cells is presented, focusing on the pathogenesis of gastrointestinal-related pathologies and MAP-related infections and, on the other hand, we attempt to dissect the associated genes and pathways involved. Furthermore, the recently characterized and novel lncRNAs share common pathologies with IBD and JD, including the expression, molecular networks, and dataset analysis results. These are also presented in an attempt to identify potential biomarkers pertinent to cattle and human disease phenotypes.

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Section: Morphology and Biological Characteristics Of Mycobacterium A...mentioning

confidence: 99%

Section: Morphology and Biological Characteristics Of Mycobacterium A...mentioning

confidence: 99%

Long Non-Coding RNAs and Their “Discrete” Contribution to IBD and Johne’s Disease—What Stands out in the Current Picture? A Comprehensive Review

Triantaphyllopoulos

2023

IJMS

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“…MAP is found in the same environmental niches as FLA, including water and soil, and is the causative agent of Johne's disease, a chronic gastrointestinal disease of ruminants (Rayamajhee et al, 2022; Samba‐Louaka et al, 2018). Furthermore, there is a controversial proposed association of MAP with Crohn's disease in humans (Espeschit et al, 2023; Zou et al, 2022). Amoebae may act as catalysts of genetic modification, allowing MAP to develop phenotypes different from those expressed in the culture medium (Partridge, 2005).…”

Section: Introductionmentioning

confidence: 99%

Modelling dynamics between free‐living amoebae and bacteria

Ali,

Rice,

Byrne

et al. 2024

Environmental Microbiology

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Free‐living amoebae (FLA) serve as hosts for a variety of endosymbionts, which are microorganisms that reside and multiply within the FLA. Some of these endosymbionts pose a pathogenic threat to humans, animals, or both. The symbiotic relationship with FLA not only offers these microorganisms protection but also enhances their survival outside their hosts and assists in their dispersal across diverse habitats, thereby escalating disease transmission. This review is intended to offer an exhaustive overview of the existing mathematical models that have been applied to understand the dynamics of FLA, especially concerning their interactions with bacteria. An extensive literature review was conducted across Google Scholar, PubMed, and Scopus databases to identify mathematical models that describe the dynamics of interactions between FLA and bacteria, as published in peer‐reviewed scientific journals. The literature search revealed several FLA–bacteria model systems, including Pseudomonas aeruginosa, Pasteurella multocida, and Legionella spp. Although the published mathematical models account for significant system dynamics such as predator–prey relationships and non‐linear growth rates, they generally overlook spatial and temporal heterogeneity in environmental conditions, such as temperature, and population diversity. Future mathematical models will need to incorporate these factors to enhance our understanding of FLA–bacteria dynamics and to provide valuable insights for future risk assessment and disease control measures.

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“…Prophylactically treating at-risk livestock with MP could help prevent the development of chronic disease and potentially the frequency of passive shedding [6]. MAP has also long been considered one of many "triggering agents" involved in Crohn's disease [7]. As research progresses, evidence continues to support that MAP infection or exposure is related to the prevalence of Crohn's disease, with a regional prevalence of Crohn's disease correlated to an environmental incidence of MAP [8].…”

Section: Introductionmentioning

confidence: 99%

Alginate-Encapsulated Mycobacteriophage: A Potential Approach for the Management of Intestinal Mycobacterial Disease

O’Connell,

Coffey,

O’Mahony

2023

Viruses

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Encapsulated medication is a common method of administering therapeutic treatments. As researchers explore alternative therapies, it is likely that encapsulation will remain a feature of these novel treatments, particularly when routes of delivery are considered. For instance, alginate-encapsulation is often favoured where gastric digestion poses an obstacle. When exposed to cations (namely Ca2+), alginate readily forms gels that are resilient to acidic conditions and readily dissociate in response to mid-range pH. This action can be extremely valuable for the encapsulation of phages. The efficient delivery of phages to the intestine is important when considering mycobacteriophage (MP) therapy (or MP prophylaxis) for disseminated mycobacterial infections and chronic gastroenteritis conditions. This study presents the design and in vitro validation of an alginate-encapsulated MP capable of releasing phages in a pH-dependent manner. Ultimately, it is shown that encapsulated phages pretreated with simulated gastric fluid (SGF) are capable of releasing viable phages into simulated intestinal fluid (SIF) and thereby reducing the mycobacterial numbers in spiked SIF by 90%. These findings suggest that alginate encapsulation may be a viable option for therapeutic and prophylactic approaches to the management of intestinal mycobacterial disease, such as Johne’s disease.

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Mycobacterium avium subsp. paratuberculosis and Crohn’s disease: characterization of the interaction with different aspects of the disease

Cited by 4 publications

References 31 publications

Long Non-Coding RNAs and Their “Discrete” Contribution to IBD and Johne’s Disease—What Stands out in the Current Picture? A Comprehensive Review

Long Non-Coding RNAs and Their “Discrete” Contribution to IBD and Johne’s Disease—What Stands out in the Current Picture? A Comprehensive Review

Modelling dynamics between free‐living amoebae and bacteria

Alginate-Encapsulated Mycobacteriophage: A Potential Approach for the Management of Intestinal Mycobacterial Disease

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