Mycobacterium Avium Prosthetic Hip Infection on Abatacept Presenting as Fever of Unknown Origin

Sigler, Rachel; Newman, Jessica

doi:10.7150/jbji.35703

Cited by 6 publications

(4 citation statements)

References 10 publications

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“…There are examples in total hip arthroplasty literature of two-stage revisions being done successfully for Mycobacterium avium PJIs. 10 , 11 Falola et al 12 presented an interesting case of M kansasii native joint septic arthritis. The patient was treated with serial arthroscopic débridements and antibiotic therapy.…”

Section: Discussionmentioning

confidence: 99%

Prosthetic Knee Joint Infection Caused by Mycobacterium kansasii

Dasari¹,

Hadro²,

Singh³

et al. 2022

JAAOS Glob Res Rev

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Mycobacterium kansasii is a nontuberculous mycobacterium that is a rare cause of prosthetic joint infections (PJIs). This case report presents a 58-year-old man who developed rapidly progressive arthritis after exposing his right knee to an unknown fluid at a microbial pharmaceutical company. Within a year, he underwent a right total knee arthroplasty (TKA). At 5 months postoperatively, he presented with pain and swelling of that knee. Imaging revealed extensive periprosthetic osteolysis with diffuse intracapsular and posterior extracapsular fluid collections. Multiple knee aspirates had negative cultures, and infectious laboratory test results were equivocal. Two years after his primary arthroplasty, the patient underwent posterior débridement and one-stage revision TKA with antibiotic cement. Synovial fluid mycobacterial cultures aspirated 2 weeks before the revision surgery became positive on postoperative day 1. PCR identified M kansasii. At 3 weeks postoperatively, intraoperative periprosthetic cultures grew mycobacterium. M kansasii was confirmed using mass spectrometry. Once susceptibilities returned, the patient was treated with targeted antimycobacterial therapy. This case report demonstrates the importance of considering atypical PJI in painful TKA with negative cultures and equivocal laboratory results. In the future, when there is concern for an atypical PJI, molecular diagnostic tools and mycobacterial cultures should be used before surgical intervention.

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Section: Discussionmentioning

confidence: 99%

Prosthetic Knee Joint Infection Caused by Mycobacterium kansasii

Dasari¹,

Hadro²,

Singh³

et al. 2022

JAAOS Glob Res Rev

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“…To date, the literature has described six cases of individuals who experienced PJI due to MAC, all of whom were considered to be immunosuppressed (Gupta and Clauss, 2009;Ingraham et al, 2017;McLaughlin et al, 1994;Sigler and Newman, 2019;Sixt et al, 2020;Tan et al, 2016). In our case series, the majority of patients (three out of five) were undergoing treatment for RA, one patient had a history of systemic lupus erythematosus (SLE) and subsequent hematologic malignancy, and one patient did not have a documented immunosuppressing risk factor for the development of MAC PJI.…”

Section: Discussionmentioning

confidence: 99%

“…Guidelines for treatment of pulmonary nontuberculous mycobacteria and PJI provide little information on how to manage PJIs caused by MAC (Daley et al, 2020;Osmon et al, 2013). Among case reports published in the literature, all of the patients reported have a comorbid immune-suppressing condition, including treated rheumatoid arthritis (RA) (Ingraham et al, 2017;Sigler and Newman, 2019), solid organ transplantation (Gupta and Clauss, 2009), hematologic malignancy (Sixt et al, 2020;Tan et al, 2016), and HIV/AIDS (McLaughlin et al, 1994). Here, we present a case series of five patients treated at two institutions with PJI caused by MAC.…”

Section: Introductionmentioning

confidence: 99%

Prosthetic joint infections caused by Mycobacterium avium complex: a series of five cases

Dobos

Suh²,

Tande³

et al. 2022

J. Bone Joint Infect.

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“…In these cases, eradicating bacilli firmly adhered to artifacts is difficult due to their poor response to medication therapy, and the clinical conditions may worsen, resulting in systemic disseminated NTM disease. Owing to NTM’s slow growth, patients may experience diagnostic delays and inadequate treatment, which can have devastating effects 21 , 22 . Notably, NTM can survive in any natural environment with water, as it forms biofilms in tap water pipes, supply and drainpipes of swimming pools and public bathhouses, inside shower heads, and in the tanks of household washing machines 23 – 25 .…”

Section: Introductionmentioning

confidence: 99%

Catheter-associated Mycobacterium intracellulare biofilm infection in C3HeB/FeJ mice

Yamamoto,

Tsujimura,

Ato

2023

Sci Rep

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Non-tuberculosis mycobacterial (NTM) diseases are steadily increasing in prevalence and mortality worldwide. Mycobacterium avium and M. intracellulare, the two major pathogens of NTM diseases, are resistant to antibiotics, and chlorine, necessitating their capacity to survive in natural environments (e.g. soil and rivers) and disinfected municipal water. They can also form biofilms on artificial surfaces to provide a protective barrier and habitat for bacilli, which can cause refractory systemic disseminated NTM disease. Therefore, preventing biofilm formation by these pathogens is crucial; however, not many in vivo experimental systems and studies on NTM biofilm infection are available. This study develops a mouse model of catheter-associated systemic disseminated disease caused by M. intracellulare that reproduces the pathophysiology of catheter-associated infections observed in patients undergoing peritoneal dialysis. In addition, the bioluminescence system enabled noninvasive visualization of the amount and distribution of bacilli in vivo and conveniently examine the efficacy of antimicrobials. Furthermore, the cellulose-based biofilms, which were extensively formed in the tissue surrounding the catheter insertion site, reduced drug therapy effectiveness. Overall, this study provides insights into the cause of the drug resistance of NTM and may guide the development of new therapies for NTM diseases.

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Mycobacterium Avium Prosthetic Hip Infection on Abatacept Presenting as Fever of Unknown Origin

Cited by 6 publications

References 10 publications

Prosthetic Knee Joint Infection Caused by Mycobacterium kansasii

Prosthetic Knee Joint Infection Caused by Mycobacterium kansasii

Prosthetic joint infections caused by Mycobacterium avium complex: a series of five cases

Catheter-associated Mycobacterium intracellulare biofilm infection in C3HeB/FeJ mice

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