Mycobacterium avium complex infected cells promote growth of the pathogen Pseudomonas aeruginosa

Carazo-Fernández, Luis; González-Cortés, Carolina; López-Medrano, Ramiro; Diez-Tascón, Cristina; Marcos-Benavides, María Francisca; Rivero-Lezcano, Octavio Miguel

doi:10.1016/j.micpath.2022.105549

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…The simultaneous isolation of NTM and P. aeruginosa is not uncommon [110], and evidence from in vitro studies suggest that P. aeruginosa interferes with M. abscessus growth [111,112]. In contrast, it has been observed that P. aeruginosa growth was promoted in the presence of M. avium complex infected cells [113], suggesting that P.aeruginosa may benefit from a microenvironment created by a mycobacterial-induced bronchiectasis.…”

Section: Bronchiectasis and Nontuberculous Mycobacteriamentioning

confidence: 99%

Nontuberculous Mycobacteria, Mucociliary Clearance, and Bronchiectasis

Retuerto-Guerrero,

López-Medrano,

de Freitas-González

et al. 2024

Microorganisms

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Nontuberculous mycobacteria (NTM) are environmental and ubiquitous, but only a few species are associated with disease, often presented as nodular/bronchiectatic or cavitary pulmonary forms. Bronchiectasis, airways dilatations characterized by chronic productive cough, is the main presentation of NTM pulmonary disease. The current Cole’s vicious circle model for bronchiectasis proposes that it progresses from a damaging insult, such as pneumonia, that affects the respiratory epithelium and compromises mucociliary clearance mechanisms, allowing microorganisms to colonize the airways. An important bronchiectasis risk factor is primary ciliary dyskinesia, but other ciliopathies, such as those associated with connective tissue diseases, also seem to facilitate bronchiectasis, as may occur in Lady Windermere syndrome, caused by M. avium infection. Inhaled NTM may become part of the lung microbiome. If the dose is too large, they may grow excessively as a biofilm and lead to disease. The incidence of NTM pulmonary disease has increased in the last two decades, which may have influenced the parallel increase in bronchiectasis incidence. We propose that ciliary dyskinesia is the main promoter of bronchiectasis, and that the bacteria most frequently involved are NTM. Restoration of ciliary function and impairment of mycobacterial biofilm formation may provide effective therapeutic alternatives to antibiotics.

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Section: Bronchiectasis and Nontuberculous Mycobacteriamentioning

confidence: 99%

Nontuberculous Mycobacteria, Mucociliary Clearance, and Bronchiectasis

Retuerto-Guerrero,

López-Medrano,

de Freitas-González

et al. 2024

Microorganisms

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“…The stimulation of P. aeruginosa by mycobacteria provides evidence to explain their common clinical association [ 54 ]. In this sense, mycobacterial control strategies may be useful in reducing P. aeruginosa colonization in these types of patients [ 55 ].…”

Section: Biofilm Formation and Compositionmentioning

confidence: 99%

Mycobacterium biofilms

Muñoz-Egea

Akir

Esteban

2023

Biofilm

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Biofilms in mycobacterial infection

Umpeleva,

Skornyakov,

Vakhrusheva

2024

CMAC

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The ability to form biofilms in lung tissue destruction cavities has been described for both the causative agent of tuberculosis (Mycobacterium tuberculosis) and for non-tuberculous mycobacteria. This process is associated with the chronic infection. It is assumed that a change in the biology of the pathogen inside the biofilm (formation of an antibiotic-resistant phenotype) makes ineffective standard chemotherapy regimens, which based on the susceptibility test data of mycobacteria in the “free state”. This review describes the biology of mycobacterial biofilms and the main approaches to combat them. Available information suggests that control of mycobacterial biofilm formation is one potential strategy to improve the effectiveness of treatment for tuberculosis and mycobacteriosis.

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Mycobacterium avium complex infected cells promote growth of the pathogen Pseudomonas aeruginosa

Cited by 3 publications

References 32 publications

Nontuberculous Mycobacteria, Mucociliary Clearance, and Bronchiectasis

Nontuberculous Mycobacteria, Mucociliary Clearance, and Bronchiectasis

Mycobacterium biofilms

Biofilms in mycobacterial infection

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