Mycobacterial Lipids Induce Calcium Mobilization and Degranulation of Mast Cells

Torres-Atencio, Ivonne; Rosero, Sara; Ordoñez, Ciara; Ruiz, Michelle; Goodridge, Amador

doi:10.1164/rccm.201803-0436le

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…The recombinant MTB antigens MTSA-10, MPT-63, and ESAT-6 were found to induce the release of inflammatory mediators ( 66 ). MCs also respond specifically to MTB lipids increasing calcium influx and degranulation ( 73 ). In contrast, such immune response have been tested as therapeutic strategy for chronic diseases such as chronic spontaneous urticaria (CSU) ( 74 ).…”

Section: Mcs and Tuberculosismentioning

confidence: 99%

Uncovering the Mast Cell Response to Mycobacterium tuberculosis

et al. 2022

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The immunologic mechanisms that contribute to the response to Mycobacterium tuberculosis infection still represent a challenge in the clinical management and scientific understanding of tuberculosis disease. In this scenario, the role of the different cells involved in the host response, either in terms of innate or adaptive immunity, remains key for defeating this disease. Among this coordinated cell response, mast cells remain key for defeating tuberculosis infection and disease. Together with its effector’s molecules, membrane receptors as well as its anatomical locations, mast cells play a crucial role in the establishment and perpetuation of the inflammatory response that leads to the generation of the granuloma during tuberculosis. This review highlights the current evidences that support the notion of mast cells as key link to reinforce the advancements in tuberculosis diagnosis, disease progression, and novel therapeutic strategies. Special focus on mast cells capacity for the modulation of the inflammatory response among patients suffering multidrug resistant tuberculosis or in co-infections such as current COVID-19 pandemic.

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Section: Mcs and Tuberculosismentioning

confidence: 99%

Uncovering the Mast Cell Response to Mycobacterium tuberculosis

et al. 2022

Self Cite

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“…Such infections include Mycoplasma pneumonia [ 137 ], Escherichia coli [ 138 ], Citrobacter rodentium [ 139 ], Francisella tularensis [ 140 ], Helicobacter sp. [ 141 ], and Mycobacterium tuberculosis [ 142 ]. MCs recognize bacteria through TLR signaling and contribute to bacterial clearance by inducing immune cell recruitment and by linking the innate and adaptive immune response through promoting DC maturation ( Figure 1 A) [ 83 ].…”

Section: Role Of Mast Cells In Barrier Integrity and Host Defensementioning

confidence: 99%

Mast Cells in the Skin: Defenders of Integrity or Offenders in Inflammation?

Voß

Kotrba

Gaffal

et al. 2021

IJMS

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Mast cells (MCs) are best-known as key effector cells of immediate-type allergic reactions that may even culminate in life-threatening anaphylactic shock syndromes. However, strategically positioned at the host–environment interfaces and equipped with a plethora of receptors, MCs also play an important role in the first-line defense against pathogens. Their main characteristic, the huge amount of preformed proinflammatory mediators embedded in secretory granules, allows for a rapid response and initiation of further immune effector cell recruitment. The same mechanism, however, may account for detrimental overshooting responses. MCs are not only detrimental in MC-driven diseases but also responsible for disease exacerbation in other inflammatory disorders. Focusing on the skin as the largest immune organ, we herein review both beneficial and detrimental functions of skin MCs, from skin barrier integrity via host defense mechanisms to MC-driven inflammatory skin disorders. Moreover, we emphasize the importance of IgE-independent pathways of MC activation and their role in sustained chronic skin inflammation and disease exacerbation.

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“…Such infections include Mycoplasma pneumonia [137], Escherichia coli [138], Citrobacter rodentium [139], Francisella tularensis [140], Helicobacter sp. [141], and Mycobacterium tuberculosis [142]. MCs recognize bacteria through TLR signaling and contribute to bacterial clearance by inducing immune cell recruitment and by linking the innate and adaptive immune response through promoting DC maturation (Figure 1A) [83].…”

Section: The Role Of Mast Cells In Bacterial Infectionsmentioning

confidence: 99%

Mast Cells in the Skin: Defenders of Integrity or Offenders in Inflammation?

Voß

Kotrba

Gaffal

et al. 2021

Preprint

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Mast cells (MCs) are best known as key effector cells of immediate type allergic reactions that may even culminate in life-threatening anaphylactic shock syndromes. However, strategically positioned at host-environment interfaces and equipped with a plethora of receptors, MCs also play an important role in the first line defense against pathogens. Their main characteristic, the huge amount of preformed pro-inflammatory mediators embedded in secretory granules, allow for a rapid response and initiation of further immune effector cell recruitment. The same mechanism, however, may account for detrimental overshooting responses. MCs are not only detrimental in MC-driven diseases, but also responsible for disease exacerbation in other inflammatory disorders. Focusing on the skin as the largest immune organ, we herein review both beneficial and detrimental functions of skin MCs all the way from skin barrier integrity via host defense mechanisms to MC-driven inflammatory skin disorders. Moreover, we emphasize the importance of IgE-independent pathways of MC activation and their role in sustained chronic skin inflammation and disease exacerbation.

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Mycobacterial Lipids Induce Calcium Mobilization and Degranulation of Mast Cells

Cited by 3 publications

References 7 publications

Uncovering the Mast Cell Response to Mycobacterium tuberculosis

Uncovering the Mast Cell Response to Mycobacterium tuberculosis

Mast Cells in the Skin: Defenders of Integrity or Offenders in Inflammation?

Mast Cells in the Skin: Defenders of Integrity or Offenders in Inflammation?

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