Mycobacterial DnaQ is an Alternative Proofreader Ensuring DNA Replication Fidelity
Ming-Zhi Deng,
Qingyun Liu,
Shu-Jun Cui
et al.
Abstract:Remove of mis-incorporated nucleotides ensures replicative fidelity. Although the ϵ-exonuclease DnaQ is a well-established proofreader in the model organismEscherichia coli, proofreading in mycobacteria relies on the polymerase and histidinol phosphatase (PHP) domain of replicative polymerase despite the presence of an alternative DnaQ homolog. Here, we show that depletion of DnaQ inMycolicibacterium smegmatisresults in increased mutation rate, leading to AT-biased mutagenesis and elevated insertions/deletions… Show more
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