Mycobacterial catalases, peroxidases, and superoxide dismutases and their effects on virulence and isoniazid-susceptibility in mycobacteria - a review

Bartoš, Milan; Falkinham, Joseph O.; Pavlík, I.

doi:10.17221/5691-vetmed

Cited by 12 publications

(2 citation statements)

References 60 publications

(77 reference statements)

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“…From the standpoint of the host organism, particularly of pigs, which are the most susceptible farm animals to mycobacterial infections, contamination with both M. a. hominissuis and M. fortuitum and other conditionally pathogenic mycobacteria which may induce tuberculous lesions in the lymph nodes of pigs must be considered (Matlova et al, 2003). Especially members of M. avium complex (M. a. avium, M. a. hominissuis, and M. intracellulare) are causal agents of serious infections in animal and human populations (Dvorska et al, 1999;Pavlik et al, 2000Pavlik et al, , 2002Dvorska et al, 2002;Lescenko et al, 2003;Machackova et al, 2003Machackova et al, , 2004Bartos et al, 2004;Dvorska et al, 2004;Matlova et al, 2004a,b,c,d;Pavlik et al, 2004).…”

Section: The Risk Of Kaolin Contamination With Mycobacteriamentioning

confidence: 99%

Kaolin, bentonite, and zeolites as feed supplements for animals: health advantages and risks

Trčková¹,

Mátlová²,

Dvorská³

et al. 2004

Vet. Med.

113

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Feeding kaolin as a supplement to pigs for prevention of diarrheal diseases has been introduced into some farms in the CzechRepublic. Peat was used in the 1990s for a similar purpose; however, most farmers ceased feeding peat as a supplement because of its frequent contamination with conditionally pathogenic mycobacteria, esp. with Mycobacterium avium subsp. hominissuis. The aim of the present paper is to review available literature from the standpoint of the advantages and disadvantages related to feeding kaolin as a supplement to animals. Its positive effects exerted through the diet primarily consist in its adsorbent capability which may be useful for detoxification of the organism and for prevention of diarrheal diseases in pigs. Because the mechanism of action of kaolin fed as a supplement is unknown, a risk related to its potential interactions with other nutrient compounds of the diet exists. Therefore, it is necessary to investigate the effectiveness and safety of feeding kaolin in detail with regard to the health status and performance of each farm animal species. The disadvantage of kaolin use is its potential toxicity, provided it has been mined from the environment with natural or anthropogenic occurrence of toxic compounds. Another risk factor is a potential contamination of originally sterile kaolin with conditionally pathogenic mycobacteria from surface water, dust, soil, and other constituents of the environment in the mines during kaolin extraction, processing and storage.

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Section: The Risk Of Kaolin Contamination With Mycobacteriamentioning

confidence: 99%

Kaolin, bentonite, and zeolites as feed supplements for animals: health advantages and risks

Trčková¹,

Mátlová²,

Dvorská³

et al. 2004

Vet. Med.

113

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“…Although it is not known if pigs are a source of human MAC infection, care should be taken when using feed supplements, such as peat and clay minerals (kaolin, bentonite, and zeolite) that may increase the risk of pigs becoming infected with MAC. Human infections caused by the members of MAC are considered serious diseases very o�en resistant to and tituberculotic treatment Bartos et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Tuberculous lesions in pig lymph nodes caused by kaolin fed as a supplement

Mátlová¹,

Dvorská²,

Bartoš³

et al. 2004

Vet. Med.

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An increased incidence of tuberculous lesions in head and mesenteric lymph nodes from slaughtered pigs weighing about 115 kg was recorded in a herd of pigs kept in two farms A and B in the Czech Republic. Tuberculous lesions were more frequently (P < 0.01) diagnosed in pigs from Farm A (10.4%) than from Farm B (1.1%). The follow-up investigation of potential sources of infection on Farm A revealed that the piglets were fed kaolin from a nearby mine as a supplement. Among 20 samples from the pigs' environment, atypical conditionally pathogenic mycobacteria (ACPM) were detected in four samples as follows: dust (n = 2), pig faeces (n = 1) and kaolin fed as a supplement (n = 1). Mycobacterium avium subsp. hominissuis of genotype IS901-and IS1245+ and serotype 8 was isolated from kaolin and pig lymph nodes, M. fortuitum from stable dust and pig faeces and other ACPM from stable dust. When kaolin feeding to piglets ceased, the incidence of tuberculous lesions in these pigs at slaughter 5-6 months later decreased from 16.1% to 3.4%. No ACPM was detected on Farm B in 27 samples from the environment. An investigation of surface kaolin mines did not detect mycobacteria in non-extracted kaolin. However, surface water (three isolates among 13 samples) from the pond used for kaolin levigation and 23 batches of the final product of kaolin (10 samples from each batch, i.e. a total of 230 samples were examined) were contaminated with ACPM. Among the la�er, ACPM were isolated from three samples originating from three different batches. ACPM were likely to survive during transport of the kaolin, as a suspension through the pipeline, and during its further processing to the final product (sedimentation, addition of colloid substances, drying and other procedures).

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Control and Eradication of Bovine Tuberculosis in Central Europe

Pavlík¹

2006

Mycobacterium Bovis Infection in Animals and Humans

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Mycobacterial catalases, peroxidases, and superoxide dismutases and their effects on virulence and isoniazid-susceptibility in mycobacteria - a review

Cited by 12 publications

References 60 publications

Kaolin, bentonite, and zeolites as feed supplements for animals: health advantages and risks

Kaolin, bentonite, and zeolites as feed supplements for animals: health advantages and risks

Tuberculous lesions in pig lymph nodes caused by kaolin fed as a supplement

Control and Eradication of Bovine Tuberculosis in Central Europe

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