Mycobacteria and autoimmunity

Ribeiro, Francinne Machado; Goldenberg, Telma

doi:10.1177/0961203314559634

Cited by 31 publications

(19 citation statements)

References 88 publications

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“…Further, the present case exemplifies the already described association between mycobacterial infections and autoimmune phenomena, including the emergence of diverse autoantibodies, such as ANA, antineutrophil cytoplasmic antibodies, and anti-SSA/Ro antibodies ( 15 ). Recently, Chao et al have described a significant association between non-tuberculous mycobacterial infection and SS ( 16 ), which can be reflecting the pathogenic involvement of mycobacterial infections in SS.…”

Section: Discussionsupporting

confidence: 80%

First Association of Interleukin 12 Receptor Beta 1 Deficiency with Sjögren’s Syndrome

et al. 2017

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IntroductionInterleukin 12 receptor beta 1 (IL12Rβ1) deficiency is a primary immunodeficiency resulting mainly in susceptibility to opportunistic infection by non-tuberculous, environmental mycobacteria and severe infection caused by Salmonella spp. Till now, less than 300 patients with IL12Rβ1 deficiency have been reported. Among them, only three have been described to develop autoimmunity.Case presentationWe present the case of a 50-year-old male with IL12Rβ1 deficiency due to compound heterozygosity [c. 1623_1624delGCinsTT (pGln542Stop) and c.1791 + 2T > C (donor splice site)], who—18 months after diagnosis of disseminated BCGitis—presented with recurrent fever and sicca syndrome. No indication of an infectious origin of these symptoms could be found at that point. The diagnosis of a Sjögren’s syndrome (SS) was made on the basis of fulfilled American-European consensus classification criteria, including a positive minor salivary gland biopsy.ConclusionApart from persistent antigenic stimulation, which may drive autoimmune inflammation in primary immunodeficiency, evidence on the involvement of interleukin 12 in pathogenesis of SS suggests that the same immunological mechanism may underlie both defense against infection and the maintenance of tolerance. To our knowledge, this is the first report of a case of autoimmunity in the form of SS in a patient with a primary immunodeficiency and one of the rare cases of IL12Rβ1 deficiency with manifested autoimmunity.

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Section: Discussionsupporting

confidence: 80%

First Association of Interleukin 12 Receptor Beta 1 Deficiency with Sjögren’s Syndrome

et al. 2017

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“…The patient in this report had a medical history of pelvic tuberculosis and oligomenorrhea or amenorrhea occurred after anti-tuberculosis therapy. While mycobacterial tuberculosis infections are known to induce the development of autoantibodies and even autoimmune diseases [20, 21]. In a recent study of ROS case, it demonstrated that IgG/IgM-antibodies directed against some forms of gonadotropins were found in serum and respective antibodies in this serum only react with some but not all forms of FSH [13].…”

Section: Discussionmentioning

confidence: 99%

Successful live birth in a woman with resistant ovary syndrome following in vitro maturation of oocytes

Pan

Yuan

et al. 2016

J Ovarian Res

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BackgroundResistant ovary syndrome (ROS) is a rare endocrine disorder characterized with hypergonadotrophic hypogonadism. Infertility is a common complaint of woman presenting with ROS, and little progress has been made in term of reproduction with the patient’s own gamete. So far only one case report of live birth has been reported after in vitro maturation (IVM) of oocytes in a patient suffering from ROS in 2013.Case presentationA secondary infertile woman of 33 years-old was manifested with oligomenorrhea and markedly increased gonadotropin levels around postmenopausal range, but had normal antral follicle count, normal serum inhibin B and anti-Müllerian hormone levels. She had normal karyotype of 46,XX and normal thyroid function. There were no abnormal findings in some autoantibody assays and FSH receptor sequencing. After oral contraceptive pills combined with triptorelin depot were administered, her gonadotropin levels reduced but it showed no response to high doses of exogenous gonadotropins (hp-HMG 300IU/d for 15 days). Then endometrium was prepared with estradiol valerate and IVM from small antral follicles were performed. Five immature oocytes were retrieved. Twenty-four hours after IVM culture, 3 oocytes matured to metaphase II stage and were inseminated by intracytoplasmic sperm injection using her husband’s sperm. Two top-quality embryos were transferred and one embryo was cryopreserved. The patient got pregnant and delivered a healthy boy at term.ConclusionIVM using their own oocytes could be an available treatment for infertile women with ROS.

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“…Yet, we cannot exclude the possibility of a T-cell independent humoral immune response against retina antigens nor potential molecular mimicry as has been demonstrated to exist for mycobacterial heat-shock protein-65 and medium molecular weight neurofilament (NF-M). 25,26 Discrepancies between autoantibody positivity and the absence of detectable circulating autoreactive T-cells have been observed in other disease entities as well, for instance in anti-Hu antibody-associated paraneoplastic neurological syndromes. 27 The high ARA prevalence observed in our current study might be an overestimation as the number of patients per uveitis group was small.…”

Section: Discussionmentioning

confidence: 99%

No Evidence for Circulating Retina Specific Autoreactive T-cells in Latent Tuberculosis-associated Uveitis and Sarcoid Uveitis

Schrijver

Hardjosantoso

Berge

et al. 2020

Ocular Immunology and Inflammation

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Purpose: To detect circulating retina-specific autoreactive CD4 + T-cells and antiretinal antibodies (ARA) in latent tuberculosis (TB)-associated uveitis or sarcoid uveitis patients. Methods: The presence of crude retinal extract (RE) autoreactive CD4 + T-cells was determined by a highly sensitive flowcytometric-based technique examining co-expression of CD25 and CD134 (OX40) on RE stimulated PBMC. The presence of ARA in available matched serum samples was assessed by indirect immunofluorescence. Results: No autoreactive CD4 + T-cells against RE could be detected in either latent TB-associated uveitis or sarcoid uveitis patients, while ARA were detected in the serum of the majority (5/6) of latent TBassociated uveitis and all (3/3) sarcoid uveitis patients. Conclusion: Even with the use of this highly sensitive flowcytometric technique circulating retinaspecific autoreactive CD4 + T-cells could not be detected. In contrast, ARA were detected in the majority of patients indicating an adaptive humoral immune response toward retinal antigens had occurred.

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Mycobacteria and autoimmunity

Cited by 31 publications

References 88 publications

First Association of Interleukin 12 Receptor Beta 1 Deficiency with Sjögren’s Syndrome

First Association of Interleukin 12 Receptor Beta 1 Deficiency with Sjögren’s Syndrome

Successful live birth in a woman with resistant ovary syndrome following in vitro maturation of oocytes

No Evidence for Circulating Retina Specific Autoreactive T-cells in Latent Tuberculosis-associated Uveitis and Sarcoid Uveitis

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