Mycobacillin

Banerjee, Ayan; Majumdar, S. K.; Bose, S. K.

doi:10.1007/978-3-642-46054-8_24

Biosynthesis 1967

DOI: 10.1007/978-3-642-46054-8_24

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Mycobacillin

Ayan Banerjee¹,

S. K. Majumdar²,

S. K. Bose³

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1972

1987

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Cited by 2 publications

References 15 publications

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Differential Amino Acid Requirements for Sporulation in Bacillus subtilis

Doering

Bott

1972

J Bacteriol

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The amino acid requirements for sporulation were studied by use of auxotrophic mutants of Bacillus subtilis 168. Cells were grown to T 0 in medium containing the test amino acid and were then transferred to a minimal medium lacking that amino acid. Omission of leucine caused no reduction in sporulation. Omission of methionine, lysine, and phenylalanine appeared to cause reduced levels of sporulation, and sporulation was completely inhibited when isoleucine, tryptophan, and threonine were omitted. The amino acids in this third class showed a sequence of requirements, with tryptophan required earlier than isoleucine, which in turn was required earlier in the sporulation process than threonine. Isoleucine omission did not affect the early sporulation functions of extracellular protease formation or septum formation, but prevented the increased levels of protein synthesis and oxygen consumption that normally accompany early sporulation stages. Isoleucine did not appear to be metabolized to other compounds in significant amounts during sporulation. The role of isoleucine in the sporulation process remains unclear.

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Differential Amino Acid Requirements for Sporulation in Bacillus subtilis

Doering

Bott

1972

J Bacteriol

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Effects of antibiotics and other inhibitors on ATP-dependent protein translocation into membrane vesicles

Tai¹

1987

J Bacteriol

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The effects of several membrane antibiotics and other agents on ATP-dependent protein translocation were examined in membrane vesicles under conditions where no significant proton motive force was present. The membrane perturbants ethanol and procaine abolished ATP-dependent protein translocation. Phenethyl alcohol at low concentrations abolished translocation, whereas at high concentrations it allowed precursors to be translocated but inhibited their processing. Translocation of precursors promoted by phenethyl alcohol was temperature dependent and occurred without an added energy source but was enhanced by ATP. However, such precursors could not be further processed to mature forms upon removal of the alcohol. The membrane-active antibiotics polymyxin B and gramicidin S were strong inhibitors of translocation, whereas gramicidin D, cerulenin, and mycobacillin had no effect even at higher concentrations, indicating some specificity in interference with protein translocation. Duramycin, an antibiotic previously shown to affect protein-lipid interaction, severely impaired protein translocation. These results showed that membrane structures play important roles, either directly or indirectly, in protein translocation. Chelating agents

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Mycobacillin

Cited by 2 publications

References 15 publications

Differential Amino Acid Requirements for Sporulation in Bacillus subtilis

Differential Amino Acid Requirements for Sporulation in Bacillus subtilis

Effects of antibiotics and other inhibitors on ATP-dependent protein translocation into membrane vesicles

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