MYC Amplification in Two Further Cases of Acute Myeloid Leukemia with Trisomy 4 and Double Minute Chromosomes

O'Malley, F. M.; Rayeroux, Kathleen C.; Cole‐Sinclair, Merrole; Tong, Michael C. F.; Campbell, Lynda J.

doi:10.1016/s0165-4608(98)00160-5

Cited by 23 publications

(20 citation statements)

References 10 publications

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“…Fourteen cases of dmin in acute leukaemia have been analysed using molecular techniques. [22][23][24] Of these, 10 were shown to contain MYC sequences (normally located at 8q24), three showed amplification of MLL sequences 10,12 and one showed amplification of various genes on 11q23-24. 22 Our study contributes a further five acute leukaemias with MLL sequences present on dmin.…”

Section: Discussionmentioning

confidence: 99%

MLL amplification in acute leukaemia: a United Kingdom Cancer Cytogenetics Group (UKCCG) study

et al. 2000

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The MLL gene, located at 11q23, is frequently rearranged in acute leukaemia as either chimaeric fusion genes or partial tandem duplications. We report a series of 12 acute leukaemia cases with apparent amplification of the MLL gene ascertained using fluorescence in situ hybridisation (FISH). Seven cases showed intrachromosomal amplification of MLL, four cases showed extrachromosomal amplification as double minute chromosomes (dmin) and one case had separate subclones with dmin and homogenously staining region (hsr). Southern blot analysis of the MLL gene showed MLL gene rearrangement in three of the 10 successful cases. These cases do not naturally fall into either of the two recognised categories of MLL rearrangement and may represent a third variety of MLL gene abnormalities.

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Section: Discussionmentioning

confidence: 99%

MLL amplification in acute leukaemia: a United Kingdom Cancer Cytogenetics Group (UKCCG) study

et al. 2000

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“…5 Most of the dmins described in leukemia are the result of amplification of the c-MYC gene. 6 We report the first case of a secondary myelodysplastic syndrome (MDS) with dmins and c-MYC amplification in a child after chemotherapy for acute lymphoblastic leukemia (ALL).…”

Section: Correspondencementioning

confidence: 99%

“…Dmin chromosomes have been described in both de novo and therapy-related AML and MDS. 6,7 However, amplified DNA sequences in acute leukemia have not been well characterized by molecular methods. Of the cases identified with dmins, molecular studies showed that the c-MYC gene is amplified in most cases.…”

Section: Figurementioning

confidence: 99%

“…Of the cases identified with dmins, molecular studies showed that the c-MYC gene is amplified in most cases. 6 Dmins tend to occur in elderly patients who had AML or MDS. 6,7 To date, dmins have been observed in only one case of childhood secondary T cell ALL.…”

Section: Figurementioning

confidence: 99%

“…6 Dmins tend to occur in elderly patients who had AML or MDS. 6,7 To date, dmins have been observed in only one case of childhood secondary T cell ALL. 5 In most reported cases, dmins have occurred in association with other complex chromosomal abnormalities, or chromosomal aneusomy.…”

Section: Figurementioning

confidence: 99%

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Double minute chromosomes and c-MYC amplification in a child with secondary myelodysplastic syndrome after treatment for acute lymphoblastic leukemia

et al. 2000

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Double minute chromosomes in monoblastic (M5) and myeloblastic (M2) acute myeloid leukemia: Two case reports and a review of literature

et al. 2004

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Double minutes (dmin) are small, paired chromatin bodies that lack a centromere and represent a form of extrachromosomal gene amplification. Although they have been found in a variety of solid tumors, their presence in hematological malignancies, especially acute myeloid leukemia (AML), is rare. In addition, the presence of dmin may be a mechanism for upregulated oncogene expression and is generally associated with a poor prognosis. We describe two patients who had dmin at initial presentation of AML, including the first case of M5a with C-MYC amplification on dmin, and another case with C-MYC amplification as the only cytogenetic finding. We review here a total of 33 cases with dmin in AML. C-MYC was amplified by the dmin in 25 cases, while other putative oncogenes were amplified in the other 8. Am.

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MYC Amplification in Two Further Cases of Acute Myeloid Leukemia with Trisomy 4 and Double Minute Chromosomes

Cited by 23 publications

References 10 publications

MLL amplification in acute leukaemia: a United Kingdom Cancer Cytogenetics Group (UKCCG) study

MLL amplification in acute leukaemia: a United Kingdom Cancer Cytogenetics Group (UKCCG) study

Double minute chromosomes and c-MYC amplification in a child with secondary myelodysplastic syndrome after treatment for acute lymphoblastic leukemia

Double minute chromosomes in monoblastic (M5) and myeloblastic (M2) acute myeloid leukemia: Two case reports and a review of literature

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