MybA, a new player driving survival of the conidium of the human pathogen Aspergillus fumigatus

Bayram, Özgür; Latgé, Jean Paul

doi:10.1007/s00294-017-0740-5

Cited by 12 publications

(2 citation statements)

References 35 publications

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“…Our results found that genes responsible for intracellular trehalose production were downregulated in ΔBbcmr1 , and the content of intracellular trehalose was also reduced. We supposed that the decreased viability and significantly increased susceptibility of ΔBbcmr1 conidia to stressors could be partially attributed to trehalose changes, as observed in other filamentous fungi ( 45 , 47 , 48 ).…”

Section: Discussionmentioning

confidence: 87%

The Zinc Finger Transcription Factor BbCmr1 Regulates Conidium Maturation in Beauveria bassiana

et al. 2022

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Section: Discussionmentioning

confidence: 87%

The Zinc Finger Transcription Factor BbCmr1 Regulates Conidium Maturation in Beauveria bassiana

et al. 2022

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“…One of the fundamental functions of fungal photoreception is self-defense against the harmful effects of UV light. Fungal spores are densely packed with protective pigments and osmolytes which protect the next generation of fungi from stressors such as UV light and oxidative stress [31][32][33]. The second fundamental function of photoreception is possibly to find optimum conditions or time for spore dispersal [34,35].…”

Section: Fungal Light Responsesmentioning

confidence: 99%

An Anatomy of Fungal Eye: Fungal Photoreceptors and Signalling Mechanisms

Bayram

2023

JoF

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Organisms have developed different features to capture or sense sunlight. Vertebrates have evolved specialized organs (eyes) which contain a variety of photosensor cells that help them to see the light to aid orientation. Opsins are major photoreceptors found in the vertebrate eye. Fungi, with more than five million estimated members, represent an important clade of living organisms which have important functions for the sustainability of life on our planet. Light signalling regulates a range of developmental and metabolic processes including asexual sporulation, sexual fruit body formation, pigment and carotenoid production and even production of secondary metabolites. Fungi have adopted three groups of photoreceptors: (I) blue light receptors, White Collars, vivid, cryptochromes, blue F proteins and DNA photolyases, (II) red light sensors, phytochromes and (III) green light sensors and microbial rhodopsins. Most mechanistic data were elucidated on the roles of the White Collar Complex (WCC) and the phytochromes in the fungal kingdom. The WCC acts as both photoreceptor and transcription factor by binding to target genes, whereas the phytochrome initiates a cascade of signalling by using mitogen-activated protein kinases to elicit its cellular responses. Although the mechanism of photoreception has been studied in great detail, fungal photoreception has not been compared with vertebrate vision. Therefore, this review will mainly focus on mechanistic findings derived from two model organisms, namely Aspergillus nidulans and Neurospora crassa and comparison of some mechanisms with vertebrate vision. Our focus will be on the way light signalling is translated into changes in gene expression, which influences morphogenesis and metabolism in fungi.

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Protein O-mannosyltransferases are required for sterigmatocystin production and developmental processes in Aspergillus nidulans

Oki

Goto

et al. 2018

Curr Genet

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Aspergillus nidulans produces sterigmatocystin (ST), a precursor of a carcinogenic secondary metabolite aflatoxin (AF), during its developmental process. ST biosynthesis has been shown to be affected by various regulatory factors. In this study, we investigated the involvement of O-mannosyltransferases (PmtA, PmtB, PmtC), in ST production and morphological development. Deletion of pmtA (ΔpmtA), pmtB (ΔpmtB) or pmtC (ΔpmtC) caused no spore production and a significant decline of vegetative growth. A tremendous decline of ST level was observed in all Δpmt mutants at the third day after inoculation. By extending the growth period, ST production of ΔpmtA and ΔpmtB increased to the wild-type level 7 days after inoculation. On the other hand, ST was not detected from 7- or 14-day cultures in ΔpmtC. Expression levels of aflR gene, an essential regulator of the ST biosynthesis pathway, were also down-regulated in the Δpmt strains. By introducing the aflR overexpression cassette, ST production in the ΔpmtA and ΔpmtB significantly increased to levels comparable to the wild type. However, the presence of the aflR overexpression cassette could not improve ST production in the ΔpmtC mutant. These data suggest that the PMT family is a new endogenous factor that is required for ST biosynthesis in A. nidulans. These findings provide better understanding of the regulatory mechanisms of AF/ST biosynthesis, which can ultimately contribute to our ability to control aflatoxin contamination.

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MybA, a new player driving survival of the conidium of the human pathogen Aspergillus fumigatus

Cited by 12 publications

References 35 publications

The Zinc Finger Transcription Factor BbCmr1 Regulates Conidium Maturation in Beauveria bassiana

The Zinc Finger Transcription Factor BbCmr1 Regulates Conidium Maturation in Beauveria bassiana

An Anatomy of Fungal Eye: Fungal Photoreceptors and Signalling Mechanisms

Protein O-mannosyltransferases are required for sterigmatocystin production and developmental processes in Aspergillus nidulans

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