Myasthenia-Like Syndrome Induced by Overdosage of Cibenzoline.

Abstract

A case of cibenzoline-induced myasthenia-like syndrome is reported. A 67-year-old woman with renal failure and no previous disorder of neuromuscular junction complained of fatigue during climbing up a flight of stairs and experiencing heavy eyelids after administration of100 mg/ day of cibenzoline. Repetitive nerve stimulation tests revealed decrement at 5-10 Hz. After reduction of the dosage, myasthenia-like signs and symptomsdisappeared. The peak cibenzoline concentration was still high even after the dose reduction (666.4 ng/ml). In conclusion, cibenzoline, at a high plasma level, may induce myasthenia-like syndrome without any disorder of the neuromuscular junction. (Internal Medicine 35: 512-514, 1996)

Severe Respiratory Failure and Torsades de Pointes Induced by Disopyramide in a Patient with Myasthenia Gravis

“…Ne g a t i v e T wa v e p e r s i s t e d u n t i l 4 7 t h d a y o n t h e E CG f i n d i n g s a n d t h e n g r a d u a l l y n o r ma l i z e d . (8,9 (3,5,6,11) and hypokalemia (12 …”

Myasthenialike syndrome due to adverse effects of cibenzoline in a patient with chronic renal failure

“…Recently, Kasuga et al 5 reported a case of mild myasthenialike syndrome induced by cibenzoline in a patient with renal failure. We suggest that particular caution is needed if cibenzoline is given to patients with renal dysfunction.…”