Myasthenia Gravis with Thymoma: Analysis of and Postoperative Prognosis for 65 Patients with Thymomatous Myasthenia Gravis

Monden, Yasumasa; Nakahara, Kazunari; Kagotani, K; Fujii, Yoshitaka; Masaoka, Akira; Kawashima, Yasunaru

doi:10.1016/s0003-4975(10)62185-6

Cited by 63 publications

(22 citation statements)

References 23 publications

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“…An interesting exception was patient DE, who suffered from myasthenia for 20 years, was intermittently treated with azathioprine, and was found to have a benign thymoma. As reported in other studies (2,46), the neoplastic tissue portion was joined by residual thymus tissue with lympho-follicular hyperplasia and marked germinal center formation and preponderant mature T3' lymphocytes. Almost all of the thymomatous thymocytes had the immature, "cortical" T6' phenotype, as described in other thymomas (47).…”

Section: Methodssupporting

confidence: 77%

Thymus in myasthenia gravis. Isolation of T-lymphocyte lines specific for the nicotinic acetylcholine receptor from thymuses of myasthenic patients.

Melms¹,

Schalke²,

Kirchner³

et al. 1988

J. Clin. Invest.

142

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The thymus is believed to play a central role in the pathogenesis of Myasthenia gravis (MG). According to a previous hypothesis, MG is initiated within the thymus by immunogenic presentation of locally produced nicotinic acetylcholine receptor (AChR) to potentially autoimmune T cells. Data of 10 consecutive MG patients demonstrate two critical features of MG thymuses that support the concept of intrathymic activation of autoreactive, AChR-specific lymphocytes. Morphologically, the thymuses showed lympho-follicular hyperplasia in nine cases and benign thymoma in one case. The paramount feature revealed by immunohistological double marker analyses was the intimate association of myoid cells (antigen producing) with interdigitating reticulum cells (potentially antigen presenting cells), both of which were surrounded by T3+ lymphocytes in thymus medulla. All 10 thymuses contained T lymphocytes reactive with AChR. This was in contrast to the peripheral immune compartment (blood) where in only 3 of 10 patients, significant T cell responses to AChR were observed. AChR-specific T cell lines could be established from 8 of 10 thymuses, all members of the helper/inducer subset as indicated by the expression of markers T3 and T4.

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Section: Methodssupporting

confidence: 77%

Thymus in myasthenia gravis. Isolation of T-lymphocyte lines specific for the nicotinic acetylcholine receptor from thymuses of myasthenic patients.

Melms¹,

Schalke²,

Kirchner³

et al. 1988

J. Clin. Invest.

142

View full text Add to dashboard Cite

show abstract

“…[22] The most common PNS associated are MG (30-50%), Cushing syndrome, pure red blood cell aplasia, hypogammaglobulinemia, limbic encephalitis ,and rheumatoid arthritis. In this series, PNS was associated in 20 patients, 17 having MG and 3 having Cushing syndrome.…”

Section: Discussionmentioning

confidence: 99%

Thymoma: Clinical experience from a tertiary care institute from North India

Kumar

Bera

et al. 2013

J Can Res Ther

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“…12 Other factors, including completeness of resection, tumor size, involvement of vessels, and association with myasthenia gravis, have also been reported to have correlations with postoperative outcome. [13][14][15][16][17][18][19][20][21] Postoperative outcomes of patients with thymomas with reference to completeness of resection and involvement of the great vessels are shown in Figs. 2 and 3, respectively.…”

Section: Correlation Of Who Histological Classifi Cation With Oncologmentioning

confidence: 99%

Clinical and pathological aspects of thymic epithelial tumors

Okumura

Shiono

Minami

et al. 2008

Gen Thorac Cardiovasc Surg

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A histological classification of thymic epithelial tumors was presented by the World Health Organization (WHO) in 1999 and again in 2004 following slight modifications, in which thymic epithelial tumors were categorized as thymomas and thymic carcinomas. Whereas thymoma is defined as an organotypic (thymus-like) tumor, thymic carcinoma is a malignant epithelial neoplasm with a morphology similar to that of malignant neoplasms arising from other organs. Herein, the recent progress in research of thymic epithelial tumors is reviewed with reference to the WHO histological classification system, with the focus on thymomas. Thymomas are classified into five types--A, AB, B1, B2, B3--according to the shape and atypia of their epithelial cells as well as the abundance of lymphocytes. The invasiveness, prognosis, and genetic imbalance of thymomas have been shown to be related to this classification system. Myasthenia gravis is frequently associated with types B1 and B2. The WHO histological classification of thymomas is not only useful for treatment but reflects their biological characteristics, including genetic alterations. Advances are expected in future studies of thymomas from the standpoint of their clinical, pathological, and biological aspects.

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Myasthenia Gravis with Thymoma: Analysis of and Postoperative Prognosis for 65 Patients with Thymomatous Myasthenia Gravis

Cited by 63 publications

References 23 publications

Thymus in myasthenia gravis. Isolation of T-lymphocyte lines specific for the nicotinic acetylcholine receptor from thymuses of myasthenic patients.

Thymus in myasthenia gravis. Isolation of T-lymphocyte lines specific for the nicotinic acetylcholine receptor from thymuses of myasthenic patients.

Thymoma: Clinical experience from a tertiary care institute from North India

Clinical and pathological aspects of thymic epithelial tumors

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