Myasthenia gravis with a myeloma-type, gamma-G (IgG) immunoglobulin abnormality

Rowland, Lewis P.; Osserman, Elliott F.; Scharfman, William B.; Balsam, Richard F.; Ball, S. J.

doi:10.1016/0002-9343(69)90078-3

Cited by 29 publications

(7 citation statements)

References 24 publications

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“…Isolated instances of monoclonal gammopathy have been described in myasthenia gravis (Rowland et al, 1969) and polymyositis (Nishikai et al, 1974) and hypogammaglobulinaemia has been described in two subjects with thymoma and myasthenia (TeVelde et al, 1966;Cohen and Waxman, 1967). Simpson et al (1975) have recently reported depressed serum IgA levels in many patients with myasthenia gravis.…”

Section: Discussionmentioning

confidence: 99%

Serum immunogloblin levels in myasthenia gravis, polymyositis, and dermatomyositis.

Lisak¹,

Zweiman²

1976

Journal of Neurology, Neurosurgery & Psychiatry

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Section: Discussionmentioning

confidence: 99%

Serum immunogloblin levels in myasthenia gravis, polymyositis, and dermatomyositis.

Lisak¹,

Zweiman²

1976

Journal of Neurology, Neurosurgery & Psychiatry

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“…In one case report, MG preceded the development of MM by 20 years [80] . In addition, MG was described in a patient with extramedullary plasmacytoma and in another patient with MM [81] , [82] .…”

Section: Autoimmune Neurologic Disorders In Multiple Myelomamentioning

confidence: 98%

Autoimmune manifestations in patients with multiple myeloma and monoclonal gammopathy of undetermined significance

et al. 2016

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BackgroundMultiple myeloma (MM) and its precursor, monoclonal gammopathy of undetermined significance (MGUS), have been linked with several autoimmune conditions in the medical literature. Yet, significance of these associations is not well understood.MethodsHerein, we provide a comprehensive literature review on autoimmune disorders identified in patients with MM and MGUS. Most relevant papers were identified via searching the PubMed/Medline and EMBASE databases for articles published from inception until May 1, 2016.FindingsScientific literature on autoimmune conditions in patients with MM and MGUS consists of several case series and a multitude of case reports. Our analysis suggests an increased prevalence of autoimmune conditions in patients with MM and monoclonal gammopathy of undetermined significance (MGUS), including various autoimmune hematologic and rheumatologic conditions among other entities. Conversely, persons with various autoimmune conditions tend to have a higher prevalence of MGUS and MM than the general population.ConclusionsFuture research is required to explore further the link between MGUS/MM and autoimmune disorders. Inflammation in the setting of autoimmunity may serve as a trigger for MGUS and MM. In addition, a common genetic susceptibility for developing both an autoimmune disease and MM/MGUS might also exist. Autoimmune hematologic and rheumatologic diseases may pose important clinical problems for the MM patients. Therefore, a catalogue of these problems is important so that physicians are able to consider, identify and address them promptly.

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“…Monoclonal gammopathies have been reported in other neurologic diseases, including myasthenia gravis (13) and ataxia-telangiectasia (I). A patient with peripheral neuropathy and a small amount of monoclonal IgM protein in his serum, was found to have infiltration of IgM-producing lymphocytes in a saphenous nerve ( 5 ) .…”

Section: ( / [ I Mcd S C Trrrrl205mentioning

confidence: 99%

Development of Biclonal Gammopathy in a Patient with von Recklinghausen's Neurofibromatosis

Wille

Ostborg

1979

Journal of Internal Medicine

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Myasthenia gravis with a myeloma-type, gamma-G (IgG) immunoglobulin abnormality

Cited by 29 publications

References 24 publications

Serum immunogloblin levels in myasthenia gravis, polymyositis, and dermatomyositis.

Serum immunogloblin levels in myasthenia gravis, polymyositis, and dermatomyositis.

Autoimmune manifestations in patients with multiple myeloma and monoclonal gammopathy of undetermined significance

Development of Biclonal Gammopathy in a Patient with von Recklinghausen's Neurofibromatosis

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