Myasthenia Gravis in Children

Wyllie, W. G.; Bodian, Martin; Burrows, N. F. Elliott

doi:10.1136/adc.26.129.457

Archives of Disease in Childhood

1951

DOI: 10.1136/adc.26.129.457

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Myasthenia Gravis in Children

W. G. Wyllie¹,

Martin Bodian²,

N. F. Elliott Burrows³

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1953

1983

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Cited by 5 publications

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Congenital Myasthenia Gravis

Clarke¹,

Velde²

1971

Am J Dis Child

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Thymectomy and subsequent short course of corticotropin in high doses did not change the course of persistent and unusually severe congenital myasthenia gravis in a 5-year-old boy. Grossly, the thymus appeared normal in size and consistency for the patient's age. On histopathologic examination several changes consistent with an autoimmune disorder were demonstrable, including lymphoid hyperplasia and large numbers of thymic plasma cells. Electron microscopic studies showed intralobular vascular changes and the presence of thymic myoid cells. Their possible significance is discussed.Although myasthenia gravis in the neonate is not common, a sufficient number of cases have been reported to allow classification into neonatal and congenital forms (Table). Neonatal myasthenia is more common and appears in 10% to 15% of infants born of myasthénie mothers. This form of myasthenia is transitory and medication is rarely required for longer than four weeks. Survival