Myasthenia gravis, Hashimoto’s disease and pernicious anaemia

Durston, J. H.

doi:10.1136/pgmj.45.522.290

Cited by 12 publications

(1 citation statement)

References 14 publications

(7 reference statements)

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“…Though less frequent, an association with pernicious anaemia has been reported (Singer & Samay 1966, Durston 1969. A review of the literature reveals that this as-sociation is found in less than 1 % of the large series (Howard et a1 1965, Reaves 1965 with the exception of Simpson's series (Simpson 1964) with 9 cases of pernicious anaemia among 491 myasthenia gravis patients.…”

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confidence: 98%

Humoral and Cellular Immunity to Intrinsic Factor in Myasthenia Gravis

Zittoun

Tulliez

Estournet

et al. 1979

Scandinavian Journal of Haematology

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Myasthenia gravis (MG) is an autoimmune disease often associated with other autoimmune disorders. A case history of MG with a coexisting atypical megaloblastic anaemia with vitamin BIZ deficiency and anti Intrinsic Factor (IF) antibodies, led to a study of humoral and cellular immunity to IF in 81 MG patients. Within this series, 3 other patients had a disturbed humoral and cellular immunity to IF. These 3 patients presented no other features of pernicious anaemia. The possible origins and significance of the anti IF antibodies in MG patients are discussed.

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mentioning

confidence: 98%

Humoral and Cellular Immunity to Intrinsic Factor in Myasthenia Gravis

Zittoun

Tulliez

Estournet

et al. 1979

Scandinavian Journal of Haematology

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Myasthenic Syndromes in Hypothyroidism

Takamori¹,

Gutmann²,

Crosby³

et al. 1972

Arch Neurol

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Two hypothyroid patients, one with autoimmune thyroiditis and pernicious anemia and the other with idiopathic primary myxedema, were studied electrophysiologically. The former showed findings of the Eaton-Lambert myasthenic syndrome, and the latter showed findings of the desensitization block of neuromuscular transmission or the conduction block at the fine terminal filaments of the motor axon. The muscle contraction study revealed the posttetanic muscle contracture without electrical discharges in the former, and the posttetanic twitch depression and the decreased tetanic force in the latter.(26: [326][327][328][329][330][331][332][333][334][335] 1972) S: )INCE the report of Feinberg et al,1 the association of myasthenia gravis and hypo¬ thyroidism has been known, although rela¬ tively infrequent as compared with its as¬ sociation with hyperthyroidism.2 To our knowledge, some of the reported myasthénie patients with hypothyroidism were not nec¬ essarily well-controlled by anticholinesterase drugs.3 7 Norris5 described three patients whose electrophysiological characteristics were not similar to those of myasthenia gravis and were termed "myasthénie syn¬ drome with poor response to edrophonium" by Pearce and Aziz.8 We report two hypothyroid patients with myasthénie syndrome the electrophysiological features of which were different from those of myasthenia gravis. The one represented the Eaton-Lam¬ bert myasthénie syndrome due to a defect of acetylcholine release from the nerve termi¬ nal in association with the findings suggesting autoimmune disturbance, and the other was suggestive of the neuromuscular transmis¬ sion defect due to a desensitization of the postjunctional receptor to acetylcholine or the conduction block at terminal branching points of the motor axon. Abnormalities of the muscle contraction were also investigat¬ ed by determining the posttetanic change of isometric twitches and the tetanus develop¬ ment. The results of electrophysiological studies in these two patients were then com¬ pared with those of 20 normal subjects, 23 patients with myasthenia gravis, and 4 pa¬ tients with Eaton-Lambert myasthénie syn¬ drome associated with bronchogenic carci¬ noma.

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Prednisone Use in Concurrent Autoimmune Diseases

Harati¹

1979

Arch Neurol

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Myasthenia gravis, Hashimoto’s disease and pernicious anaemia

Cited by 12 publications

References 14 publications

Humoral and Cellular Immunity to Intrinsic Factor in Myasthenia Gravis

Humoral and Cellular Immunity to Intrinsic Factor in Myasthenia Gravis

Myasthenic Syndromes in Hypothyroidism

Prednisone Use in Concurrent Autoimmune Diseases

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