Myasthenia gravis exacerbation after cetirizine administration

Abstract

Background Although perhaps the most common worker‐management structure, there has been surprisingly little research on describing and evaluating the characteristics of health and safety committees. Methods A survey of 380 health and safety committee members from 176 manufacturing workplaces was supplemented with administrative data and compared with reported workers' compensation rates. Survey respondents also reported perceptions of overall safety, committee, effectiveness, committee activities, and “best practices.” Results Extensive descriptive data is presented, including a mean of 8.7 members per committee spending 1,167 hr per year on committee business for an estimate of $40,500 worth of time per committee. Higher speed to correct action items, a focus on ergonomics, and planning for safety training was associated with lower injury rates. The discrepancy between managers and hourly committee members in estimating overall safety was strongly positively associated with injury rates. Conclusions Communications and worker involvement may be important to address discrepancy issues. Prospective studies are needed to distinguish directionality of associations. Am. J. Ind. Med. 56:163–179, 2013. © 2011 Wiley Periodicals, Inc.

Management of Insomnia and Anxiety in Myasthenia Gravis

“…In other words, while they may cause antimuscarinic effects (e.g., dry mouth, blurry vision, constipation, urinary retention, drowsiness), they should not theoretically produce antinicotinic effects (e.g., neuromuscular blockade or skeletal muscle weakness) the latter would be particularly problematic in myasthenia gravis (16). However, in one case it was reported that cetirizine appeared to trigger an episode of diplopia, dysphagia, and facial weakness in a patient with a history of myasthenia gravis previously in complete stable remission; the mechanism by which this likely occurred is unclear but may be related to the anticholinergic properties of the disease (17).…”