Myasthenia Gravis and Vitamin D Serum Levels: A Systematic Review
and Meta-analysis

Bonaccorso, Giovanni

doi:10.2174/1871527321666220707111344

Cited by 6 publications

(5 citation statements)

References 32 publications

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“…A mounting body of evidence has demonstrated that Tregs are functionally defective in patients with MG, emphasizing their pivotal role in immune regulation. Recent studies in healthy individuals have supported the hypothesized immune-regulating impact of vitamin D, which is believed to be connected to increased regulatory T cells [ 10 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin D deficiency is associated with various chronic autoimmune diseases such as multiple sclerosis (MS) [7], systemic lupus erythematosus (SLE) [8], and rheumatoid arthritis (RA) [9]. Recent studies and systematic reviews have demonstrated significantly lower plasma 25(OH)D levels in patients with MG relative to healthy controls, suggesting the importance of monitoring 25(OH)D levels in MG patients [10].…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D add on the standard treatment for myasthenia gravis symptoms following total gastrectomy: a case report

Zhang,

Zhong,

et al. 2024

BMC Neurol

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Background Myasthenia gravis (MG) is a long-term autoimmune disorder that affects the neuromuscular junction, causing muscle weakness and fatigue as its primary clinical features. Vitamin D is crucial for both the autoimmune response and skeletal muscle function. Case presentation Here, we presented a case report documenting the substantial improvement in symptoms experienced by a patient who underwent subtotal gastrectomy for gastric cancer following high-dose Vitamin D supplementation. The patient developed generalized MG two months after the surgery and did not respond adequately to pyridostigmine therapy, experiencing a progressive deterioration of the condition. A significant reduction in vitamin D concentration was observed following subtotal gastrectomy. In response, high-dose vitamin D supplementation was administered to the patient. Within one week of treatment, swallowing symptoms improved, enabling the consumption of a small amount of liquid food. By the second week, substantial swallowing and neck function improvements were evident. After one month, the patient regained the ability to straighten the neck while walking and consumed a regular diet despite persistent difficulties chewing hard food. Conclusions This case underscores the therapeutic potential of vitamin D in alleviating MG symptoms, particularly in individuals with compromised vitamin D levels following gastrectomy. The observed improvements present a new perspective on the possible involvement of vitamin D supplementation in the management of postoperative MG cases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vitamin D add on the standard treatment for myasthenia gravis symptoms following total gastrectomy: a case report

Zhang,

Zhong,

et al. 2024

BMC Neurol

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“…According to previous studies, vitamin D may have immunomodulatory properties, which increases tolerance to autoantigens ( 33 ). A recent meta-analysis suggests that serum vitamin D levels are significantly lower in MG patients than in healthy controls ( 34 ). It is therefore possible that vitamin D deficiency may play a role in the development of autoimmune diseases like MG.…”

Section: Discussionmentioning

confidence: 99%

Causal effect of vitamin D on myasthenia gravis: a two-sample Mendelian randomization study

et al. 2023

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IntroductionObservational studies suggest that vitamin D supplementation may be effective in preventing myasthenia gravis (MG). However, the causal relationship between circulating vitamin D levels and MG remains unclear. This study aimed to examine the genetic causality of circulating vitamin D and MG using data from large population-based genome-wide association studies (GWAS).MethodsSNPs (single nucleotide polymorphisms) strongly associated with exposure were selected. Two-sample Mendelian Randomization (MR) was performed with inverse variance weighting (IVW), MR-Egger (Mendelian randomization-Egger), weight median and MR-PRESSO (Mendelian randomization pleiotropy residual sum and outlier) methods. Heterogeneity was tested via IVW and MR-Egger. Pleiotropy was tested using MR-Egger intercept test and MR-PRESSO method. MR-PRESSO was also used to detect outliers. Leave-one-out analysis was used to identify SNPs with potential effect. Reverse MR analysis was also performed.ResultIn IVW, circulating vitamin D levels had no causal effect on MG [OR = 0.91 (0.67–1.22), p = 0.532] and MG had no causal effect on circulating vitamin D [OR = 1.01 (099–1.02), p = 0.663]. No heterogeneity or pleiotropy was observed (p > 0.05). Other MR methods also agreed with IVW results.ConclusionThis study provides the causal relationship between genetically predicted circulating vitamin D levels and MG and provides new insights into the genetics of MG.

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“…6.6.1. Micronutrients-Roles, Levels, Administration: Current Knowledge Significantly lower plasmatic concentrations of 25-OH vitamin D were observed in patients with MG [56]. Moreover, lower levels in patients with myasthenic crisis were reported compared with those of patients with MG without myasthenic crisis.…”

Section: Myasthenia Gravismentioning

confidence: 98%

The Role of Micronutrients in Neurological Disorders

Lahoda Brodska,

Klempir,

Zavora

et al. 2023

Nutrients

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Trace elements and vitamins, collectively known as micronutrients, are essential for basic metabolic reactions in the human body. Their deficiency or, on the contrary, an increased amount can lead to serious disorders. Research in recent years has shown that long-term abnormal levels of micronutrients may be involved in the etiopathogenesis of some neurological diseases. Acute and chronic alterations in micronutrient levels may cause other serious complications in neurological diseases. Our aim was to summarize the knowledge about micronutrients in relation to selected neurological diseases and comment on their importance and the possibilities of therapeutic intervention in clinical practice.

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Myasthenia Gravis and Vitamin D Serum Levels: A Systematic Review and Meta-analysis

Cited by 6 publications

References 32 publications

Vitamin D add on the standard treatment for myasthenia gravis symptoms following total gastrectomy: a case report

Vitamin D add on the standard treatment for myasthenia gravis symptoms following total gastrectomy: a case report

Causal effect of vitamin D on myasthenia gravis: a two-sample Mendelian randomization study

The Role of Micronutrients in Neurological Disorders

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