Myasthenia gravis and Guillain–Barré syndrome occurring simultaneously in the same patient

Kizilay, Ferah; Ryan, Hewitt F.; Oh, Shin J.

doi:10.1002/mus.20968

Cited by 13 publications

(10 citation statements)

References 8 publications

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“…GBS and MG occurring concomitantly in the same patient have been reported in the literature (13). In this case, we did not find any clinical or laboratory evidence for MG. We regret that we did not get the patient's permission to check for serum anti-GQ1b antibody, because the patient's symptoms were more similar to those of the ophthalmoplegia without ataxia variant of GBS or MFS, which has been reported to be more prevalent in the Taiwanese population (14).…”

Section: Discussionmentioning

confidence: 51%

Ptosis as the Initial Presentation of Guillain-Barré Syndrome

Teng

Sung

2012

The Journal of Emergency Medicine

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Section: Discussionmentioning

confidence: 51%

Ptosis as the Initial Presentation of Guillain-Barré Syndrome

Teng

Sung

2012

The Journal of Emergency Medicine

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“…3 To the best of our knowledge, the occurrence of MG and GBS overlap syndrome is quite rare. [3][4][5][6][7][8][9][10][11][12][13][14] Furthermore, only 4 studies have reported the comorbidity of MG and MFS previously. [15][16][17][18] Here, we review all previously described cases and present a new case of our own.…”

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confidence: 99%

The clinical features of patients concurrent with Guillain-Barré syndrome and myasthenia gravis

Yuan

Zhang

et al. 2018

NSJ

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“…The incidence of MG and GBS was reported to be about 0.4-1.7 and 10-20 per million persons per year accordingly. In Kizilay's and Kraus's reports, post-infectious GBS was followed by MG by 3 weeks and 10 weeks, respectively [5,6].…”

Section: Discussion and Evaluationmentioning

confidence: 95%

Occurrence of Guillain-Barré syndrome and Myasthenia Gravis in an elderly male

Karri

Ramasamy

Perumal

2019

Egypt J Neurol Psychiatry Neurosurg

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Introduction: The occurrence of both Guillain-Barré syndrome(GBS) and myasthenia gravis (MG) in the same individual is rare. The underlying pathophysiology was assumed to be autoimmune humoral mechanisms and molecular mimicry with a cross-reaction between autoantibodies and myelin sheath of peripheral nerves and acetylcholine receptors of the neuromuscular junction (NMJ). Case description: A 68-year-old male known diabetic and hypertensive with good drug compliance presented with acute onset quadriparesis with bulbar involvement for 1 day. On examination, he had mild neck flexion weakness and bulbar weakness. He had flaccid quadriparesis with absent deep tendon reflexes and negative Babinski. The rest of the neurological examination was normal. Discussion and evaluation: Blood and electrophysiological studies showed evidence of demyelinating polyradiculoneuropathy with temporal dispersion suggestive of Guillain-Barré syndrome. He was treated with intravenous immunoglobin and complete resolution of symptoms. Two months later, he presented with new-onset asymmetrical ptosis and bulbar symptoms for 3 days. On further evaluation, repetitive nerve stimulation showed postsynaptic neuromuscular disorder pattern typical of myasthenia gravis, which was further confirmed by positive acetylcholinesterase receptor antibodies (AChR). Thymoma was ruled out by imaging. He was treated with anticholinesterases, low dose steroids, and immunosuppressants (azathioprine) following which he had improvement of symptoms. Conclusion: Our patient, who was initially diagnosed with Guillain-Barré syndrome and recovered, presented 2 months later with a new-onset illness suggestive of myasthenia gravis. This existence of two different neurological entities in the same individual is a rarity, and early recognition is essential for treatment decision and prognostic strategies.

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Myasthenia gravis and Guillain–Barré syndrome occurring simultaneously in the same patient

Cited by 13 publications

References 8 publications

Ptosis as the Initial Presentation of Guillain-Barré Syndrome

Ptosis as the Initial Presentation of Guillain-Barré Syndrome

The clinical features of patients concurrent with Guillain-Barré syndrome and myasthenia gravis

Occurrence of Guillain-Barré syndrome and Myasthenia Gravis in an elderly male

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