Myasthenia Gravis and Associated Diseases

Tanovska, Nikolina; Novotni, Gabriela; Sazdova-Burneska, Slobodanka; Kuzmanovski, Igor; Boshkovski, Bojan; Кондов, Горан; Jovanovski-Srceva, Marija; Anita, Kokareva; Isjanovska, Rozalinda

doi:10.3889/oamjms.2018.110

Cited by 31 publications

(36 citation statements)

References 49 publications

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“…Coexisting ADs were detected in 14.6% of AChR-MG patients and in 17.9% of DSN-MG patients, which were consistent with the previous reported total frequency of MG (8–26%) ( 29 , 30 ). However, the frequency of coexisting AD in MuSK-MG patients was much higher (42.9%).…”

Section: Discussionsupporting

confidence: 91%

Regional Features of MuSK Antibody-Positive Myasthenia Gravis in Northeast China

et al. 2020

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Objective: To summarize the characteristics of muscle-specific receptor tyrosine kinase antibody-positive myasthenia gravis (MuSK-MG) in Northeast China. Methods: We retrospectively collected 183 confirmed MG patients and divided them into three groups based on the type of serum antibodies: MuSK-MG (14 cases), acetylcholine receptor (AChR)-MG (130 cases), and double-seronegative (DSN)-MG (39 cases). The clinical, diagnostic, therapeutic, and prognosis data were analyzed. Results: MuSK antibody was detected in 26.7% of seronegative MG. The mean age of onset in MuSK-MG was 53.2 ± 13.6 years. Fifty percent of MuSK-MG patients with an onset symptom of pure ocular muscle weakness. The time from onset to other muscle groups' involvement and the time from onset to myasthenic crisis had no significant difference among the three groups ( P > 0.05). The proportion of Osserman classification I in MuSK-MG group was lower than that in DSN-MG group. The proportion of Osserman classification IV in MuSK-MG group was higher than that in the other two groups. The incidences of other coexisting autoimmune diseases in MuSK-MG group were higher. Prognosis after the treatment of steroid combined with tacrolimus for MuSK-MG was similar to AChR-MG treated with steroid combined with an immunosuppressant agent ( P > 0.05). Conclusion: Patients with MuSK-MG in Northeast China have a modestly later onset age and a proportion of patients may have a mild form of the disease with delayed disease progression. We confirmed the existence of a rare ocular MuSK-MG phenotype, a high proportion of coexisting with other autoimmune diseases, and a good response to steroids combined with tacrolimus for our MuSK-MG series.

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Section: Discussionsupporting

confidence: 91%

Regional Features of MuSK Antibody-Positive Myasthenia Gravis in Northeast China

et al. 2020

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“…Neuromuscular diseases are a broadly defined group of disorders that involve injury or dysfunction of the peripheral nerve or muscle and include wide variety of disorders, such as multiple sclerosis (MS), Charcot–Marie–Tooth (CMT) disease, amyotrophic lateral sclerosis (ALS), myasthenia gravis (MG), and neuropathic pain [ 85 ]. The most common of these diseases is MG, which is an autoimmune disease where the immune system produces antibodies that attach themselves to the neuromuscular junction and prevent transmission of the nerve impulse to the muscle [ 86 ].…”

Section: Sex Differences In the Prevalence/incidence Of Neurologicmentioning

confidence: 99%

Effect of Caffeine Consumption on the Risk for Neurological and Psychiatric Disorders: Sex Differences in Human

et al. 2020

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Caffeine occurs naturally in various foods, such as coffee, tea, and cocoa, and it has been used safely as a mild stimulant for a long time. However, excessive caffeine consumption (1~1.5 g/day) can cause caffeine poisoning (caffeinism), which includes symptoms such as anxiety, agitation, insomnia, and gastrointestinal disorders. Recently, there has been increasing interest in the effect of caffeine consumption as a protective factor or risk factor for neurological and psychiatric disorders. Currently, the importance of personalized medicine is being emphasized, and research on sex/gender differences needs to be conducted. Our review focuses on the effect of caffeine consumption on several neurological and psychiatric disorders with respect to sex differences to provide a better understanding of caffeine use as a risk or protective factor for those disorders. The findings may help establish new strategies for developing sex-specific caffeine therapies.

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“…Associated diseases are systemic lupus erythematosus (SLE), hypertension, heart disease, and dyslipidemia. Around 10.2% were diagnosed with extrathymic tumors [23].…”

Section: Treatment Advances For Mgmentioning

confidence: 99%

Myasthenia Gravis and its Association With Thyroid Diseases

Amin¹,

Myat²,

Gandhi³

et al. 2020

Cureus

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Myasthenia gravis (MG) is a rare autoimmune neuromuscular junction disorder, and thyroid disorder is a disorder involving the thyroid receptor, of which Graves' disease (GD) is the most common autoimmune thyroid disorder, in which antibodies develop against thyroid receptors. Both may have similar clinical features. In myasthenia gravis, autoimmune antibodies develop against postsynaptic neuromuscular junction disrupting the neuromuscular transmission, resulting in fluctuating muscle weakness and fatigue. It is a disease of young women and older men. The two pathologies may coexist in a patient or can precede one another. Graves' disease (GD) among thyroid diseases is most often associated with MG. Similarities in clinical features lead to difficulty in distinguishing MG and GD. Despite the standard treatment of myasthenia gravis, including steroids, acetylcholinesterases, rituximab, immunosuppressants, and thymectomy, there is still an increased number of relapses and myasthenia crisis. Eculizumab and plasmapheresis are the two new treatment options for MG, with supporting evidence of marked improvement in recent studies. Myasthenia gravis and Graves' disease have a seesaw relationship. Treating one pathology may worsen the other, so physicians should always consider MG as a differential in patients of hyperthyroidism presenting with new symptoms of fatigue or respiratory failure or neuromuscular weakness. In this comprehensive review article, we tried to establish an association between myasthenia gravis and Graves' disease (GD) by exploring currently available literature from PubMed. However, more studies need to be done to establish an association between pathologies.

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Myasthenia Gravis and Associated Diseases

Cited by 31 publications

References 49 publications

Regional Features of MuSK Antibody-Positive Myasthenia Gravis in Northeast China

Regional Features of MuSK Antibody-Positive Myasthenia Gravis in Northeast China

Effect of Caffeine Consumption on the Risk for Neurological and Psychiatric Disorders: Sex Differences in Human

Myasthenia Gravis and its Association With Thyroid Diseases

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