Myasthenia Gravis

Strauss, A; Kemp, PiersonG; Douglas, S D

doi:10.1016/s0140-6736(66)90931-7

Cited by 50 publications

(7 citation statements)

References 4 publications

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“…1. One may suppose that the development of a thymoma causes small alterations in the thymic myoid cells (Mayer, 1888;Henry, 1966;Feltkamp-Vroom, 1966;Strauss, Kemp, and Douglas, 1966a). These altered muscle antigens might evoke immunological reactions, cross-reacting with normal muscles.…”

Section: Methodsmentioning

confidence: 99%

Muscle pathology, thymoma, and immunological abnormalities in patients with myasthenia gravis.

Oosterhuis¹,

Bethlem²,

Feltkamp³

1968

Journal of Neurology, Neurosurgery & Psychiatry

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Section: Methodsmentioning

confidence: 99%

Muscle pathology, thymoma, and immunological abnormalities in patients with myasthenia gravis.

Oosterhuis¹,

Bethlem²,

Feltkamp³

1968

Journal of Neurology, Neurosurgery & Psychiatry

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“…The small round cell of the aortic body tumour bears a superficial resemblance to the thymocyte. If relevant to the cause of human myasthenia, reports of myoid fibres withinthe thymus (Strauss, Kemp, and Douglas 1966) may be paralleled by such inclusions within aortic body tissues. While our cases do not mimic exactly all the clinical features of human myasthenia gravis, there seems to be sufficient evidence suggestive that a similar disease, and not solely a myasthenic syndrome, occurs in the dog.…”

Section: Discussionmentioning

confidence: 98%

Myasthenia gravis in the dog

Fraser

Palmer

Senior

et al. 1970

Journal of Neurology, Neurosurgery & Psychiatry

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“…Van der Geld et al (1964) observed binding of antibodies to striated muscle by certain thymic epithelial cells, that correspond to the myoid cells of early anatomists (Van der Velde and Friedman 1966). Though myoid cells exhibit immunological properties of skeletal muscle, they lack cross-striation (Strauss et al 1966). However, embryonic myoid cells do show cross-striation, but lose it during maturation (Weissenberg 1907).…”

Section: Myosin and Prekeratin In Epithelial Cellsmentioning

confidence: 99%

A comparative study of myosins and prekeratin in epithelial cells of methacarn-fixed tissues

et al. 1985

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Around the turn of the century, tonofibrils and contractile myofibrils were observed within the same cells. These findings have been largely forgotten. To clarify the topical relations of these proteins in epithelial cells, duplicate sections of methacarn-fixed human and canine tissues were treated with the tannic acid-phosphomolybdic acid (TP)-Levanol Fast Cyanine 5RN reaction for myosins and the PAP technic for prekeratin, respectively. In bronchi, lingual and sweat glands, liver and pancreas, myosin was confined to the terminal bar-terminal web system, including pericanalicular layers. Prekeratin occurred throughout the epithelium of bronchi and ducts; secretory cells showed little or no reaction. Observations on myosin in kidney confirmed data by Harper et al. (1970). The PAP technic colored transitional epithelium and collecting tubules intensely; convoluted tubules did not react. Staining of segments of Henle's loops varied from case to case. Both reactions colored thymic epithelial cells. In myoid cells of Hassall's corpuscles myosin was gradually replaced by prekeratin and keratin. Basal cells of epididymis reacted strongly with the PAP technic, but did not contain myosin. Prekeratin is apparently identical with epidermin, whose composition and structure were well known in the 1950's. Epidermin undergoes chemical changes as cells move from the stratum basale to the stratum corneum. According to DAKO, the antibodies used in this study were prepared with prekeratin extracted from stratum corneum. Data in the literature and observations in this investigation indicate that some samples of antibodies do not react with all tonofilaments.(ABSTRACT TRUNCATED AT 250 WORDS)

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Myasthenia Gravis

Cited by 50 publications

References 4 publications

Muscle pathology, thymoma, and immunological abnormalities in patients with myasthenia gravis.

Muscle pathology, thymoma, and immunological abnormalities in patients with myasthenia gravis.

Myasthenia gravis in the dog

A comparative study of myosins and prekeratin in epithelial cells of methacarn-fixed tissues

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