Myasthenia as an Autoimmune Disease: Clinical Aspects*

Wolf, Sheldon M.; Rowland, Lewis P.; Schotland, Donald L.; McKinney, Alexander S.; Hoefer, Paul F. A.; Aranow, Henry

doi:10.1111/j.1749-6632.1966.tb45500.x

Cited by 68 publications

(17 citation statements)

References 49 publications

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“…Despite individual case reports, myasthenia does not seem to show a strong relation to disorders linked with autoimmunity, other than thyroid disease (Wolf, Rowland, Schotland, McKinney, Hoefer, and Aranow, 1966). Increased incidence of thyroid, and, to a lesser extent, gastric parietal cell antibodies has been found in myasthenic patients (Simpson, 1964(Simpson, , 1966Downes, Greenwood, and Wray, 1966;Wright and Kerr, 1967), and reflects histological findings (Schade, Owen, Smart, and Hall, 1960;Wright, Whitehead, Wangel, Salem, and Schiller, 1966).…”

Section: Discussionmentioning

confidence: 99%

Experimental studies related to autoimmunity in myasthenia gravis.

Kaufman¹,

Rushworth²,

Wright³

1969

Journal of Neurology, Neurosurgery & Psychiatry

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Section: Discussionmentioning

confidence: 99%

Experimental studies related to autoimmunity in myasthenia gravis.

Kaufman¹,

Rushworth²,

Wright³

1969

Journal of Neurology, Neurosurgery & Psychiatry

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“…Myasthenia gravis has also been associated with pernicious anemia (26), systemic lupus erythematosus (9), rheumatoid arthritis (32) and auto‐immune hemolytic anemia (9, 7, 14). Myasthenia gravis and various other associated diseases may show a common underlying immune disorder (9).…”

Section: Discussionmentioning

confidence: 99%

Granulocytic Leukemia Associated with Myxedema Thyroiditis and Myasthenia Gravis

Sparagana

Grieble

Rubinstein

1972

Journal of the American Geriatrics Society

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A case of myxedema associated with Hashimoto's thyroiditis, myasthenia gravis, and granulocytic leukemia is described. The patient had the classical symptoms and signs of hypothyroidism. Profound myopathy, ptosis, and bulbar signs suggested myasthenia gravis and the diagnosis was confirmed by an anticholinesterase test. Treatment with cholinesterase inhibitors was ineffective and ACTH was given for increasing bulbar signs and ventilatory failure. Severe pneumonia supervened and was thought t o be the cause of a striking leukemoid blood picture. However, the leukemoid picture persisted after the pneumonia cleared. While convalescing, the patient died suddenly. At autopsy, granulocytic infiltrates of several organs and a hypercellular bone marrow with a preponderance of granulocytes, a decrease in erythrocytic elements and virtual absence of megakaryocytes were consistent with a diagnosis of granulocytic leukemia. The thyroid disease and the myasthenia gravis may have had an immunological basis and this may also have played a role in the development of the granulocytic leukemia.The association of myasthenia gravis, thyroid disease and certain other auto-immune disorders is well known. This report describes a patient who demonstrated the myxedema of Hashimo to's thyroiditis, myasthenia gravis and granulocytic leukemia. CASE REPORTN.D. was a 50-year-old married white male machinist. He was admitted to Hines Veterans

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“…[236][237][238] The prevalence of SLE is also increased in patients with myasthenia. The prevalence of rheumatoid arthritis in patients with myasthenia gravis may be 2 or 4 percent.…”

Section: Myasthenia Gravismentioning

confidence: 99%

Connective Tissue Diseases, Vasculitis, and the Nervous System

Rosenbaum¹

2008

Neurology and General Medicine

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Myasthenia as an Autoimmune Disease: Clinical Aspects*

Cited by 68 publications

References 49 publications

Experimental studies related to autoimmunity in myasthenia gravis.

Experimental studies related to autoimmunity in myasthenia gravis.

Granulocytic Leukemia Associated with Myxedema Thyroiditis and Myasthenia Gravis

Connective Tissue Diseases, Vasculitis, and the Nervous System

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