Myanmar Dengue Outbreak Associated with Displacement of Serotypes 2, 3, and 4 by Dengue 1

Thu, Hlaing Myat; Lowry, Kym; Myint, Thein; Shwe, Than Nu; Han, Aye Maung; Khin, Kyu Kyu; Thant, Kyaw Zin; Thein, Soe; Aaskov, John

doi:10.3201/eid1004.030216

Cited by 100 publications

(102 citation statements)

References 18 publications

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“…After exhaustively reviewing the phylogenetic literature on DENV we found only one case similar to what we describe here: the co-circulation of two lineages (B and C) of DENV-1 between 1998 and 2002 in Yangon, Myanmar, which replaced the previously circulating lineage A. 40 However, it is possible that other cases of co-circulation could have passed unnoticed because of limited sampling.…”

Section: Discussionmentioning

confidence: 96%

“…36,40 Dengue has been diagnosed in the Medellín area every single month since 2002, as reported in the laboratory-based surveillance system of this illness carried out in LDSP (Ospina MC, personal observation, data not shown). In this way the homogenizing effect of population bottlenecks could have been minimized and different lineages could have co-existed in a large and previously non-immune population.…”

Section: Discussionmentioning

confidence: 99%

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Prolonged Co-circulation of Two Distinct Dengue Virus Type 3 Lineages in the Hyperendemic Area of Medellín, Colombia

Ospina¹,

Díaz²,

Osorio³

2010

The American Society of Tropical Medicine and Hygiene

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During the past two decades, Dengue virus-3 (DENV-3) has re-emerged in the Western Hemisphere causing significant epidemics of dengue fever (DF) and dengue hemorrhagic fever (DHF). In an effort to understand the molecular evolution of DENV-3 and their relationships to other DENV-3 circulating in the western hemisphere, we conducted a phylogenetic study on DENV-3 isolates made between 2002 and 2007 in the metropolitan area of Medellín, Colombia. An unexpected co-circulation of two different variants of DENV-3 subtype III during at least 5 years in Medellín was found. In addition, a more complete analysis of DENV-3 viruses isolated in other South American regions revealed the existence of three different subtype III lineages, all derived from independent introductions. This study documents significant genetic diversity of circulating viruses within the same subtype and an unusual capacity of the population of this city to support continuous circulation of multiple variants of dengue virus.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Prolonged Co-circulation of Two Distinct Dengue Virus Type 3 Lineages in the Hyperendemic Area of Medellín, Colombia

Ospina¹,

Díaz²,

Osorio³

2010

The American Society of Tropical Medicine and Hygiene

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“…This is most evident in cases of lineage (or clade) replacement, in which there is a relatively abrupt change in the genetic composition of the infecting viruses in a specific population - that is, one viral lineage displaces another (60)(61)(62)(63)(64). There are a number of documented replacement events, and, in some of these cases, the evidence that the viruses also differ in fitness is compelling.…”

Section: Denvmentioning

confidence: 99%

RNA virus genomics: a world of possibilities

Holmes¹

2009

J. Clin. Invest.

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The increasing availability of complete genome sequences of RNA viruses has the potential to shed new light on fundamental aspects of their biology. Here, I use case studies of 3 RNA viruses to explore the impact of genomic sequence data, with particular emphasis on influenza A virus. Notably, the studies of RNA virus genomics undertaken to date largely focused on issues of evolution and epidemiology, and they have given these disciplines new impetus. However, genomic data have so far made fewer inroads into areas of more direct importance for disease, prevention, and control; thus, harnessing their full potential remains an important goal.

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“…What causes these disjunct phylogenetic patterns is unclear, although the lack of definitive evidence for fitness differences among strains has led most workers to conclude that clade extinction results from random population bottlenecks and stochastic fadeout (20,22,(24)(25)(26). We analyzed gene sequence data for all DENV serotypes circulating in Bangkok during the period 1973-2002 (see Methods) and found a concordance between episodes of clade extinction and changing levels of serotype abundance, with this process occurring on an Ϸ10-year time scale (Fig.…”

Section: Phylodynamics Of Dengue In Bangkokmentioning

confidence: 99%

Cross-protective immunity can account for the alternating epidemic pattern of dengue virus serotypes circulating in Bangkok

Adams

Holmes

Zhang

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

253

225

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Dengue virus, the causative agent of dengue fever and its more serious manifestation dengue hemorrhagic fever, is widespread throughout tropical and subtropical regions. The virus exists as four distinct serotypes, all of which have cocirculated in Bangkok for several decades with epidemic outbreaks occurring every 8 -10 years. We analyze time-series data of monthly infection incidence, revealing a distinctive pattern with epidemics of serotypes 1, 2, and 3 occurring at approximately the same time and an isolated epidemic of serotype 4 occurring in the intervening years. Phylogenetic analysis of virus samples collected over the same period shows that clade replacement events are linked to the epidemic cycle and indicates that there is an interserotypic immune reaction. Using an epidemic model with stochastic seasonal forcing showing 8-to 10-year epidemic oscillations, we demonstrate that moderate cross-protective immunity gives rise to persistent out-of-phase oscillations similar to those observed in the data, but that strong or weak cross-protection or cross-enhancement only produces in-phase patterns. This behavior suggests that the epidemic pattern observed in Bangkok is the result of cross-protective immunity and may be significantly altered by changes in the interserotypic immune reaction.cross-immunity ͉ mathematical model ͉ phylogenetics ͉ rsv ͉ phase pattern

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Myanmar Dengue Outbreak Associated with Displacement of Serotypes 2, 3, and 4 by Dengue 1

Cited by 100 publications

References 18 publications

Prolonged Co-circulation of Two Distinct Dengue Virus Type 3 Lineages in the Hyperendemic Area of Medellín, Colombia

Prolonged Co-circulation of Two Distinct Dengue Virus Type 3 Lineages in the Hyperendemic Area of Medellín, Colombia

RNA virus genomics: a world of possibilities

Cross-protective immunity can account for the alternating epidemic pattern of dengue virus serotypes circulating in Bangkok

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