Myalgia and chronic fatigue syndrome following immunization: macrophagic myofasciitis and animal studies support linkage to aluminum adjuvant persistency and diffusion in the immune system

Gherardi, Romain K.; Crépeaux, Guillemette; Authier, Florence

doi:10.1016/j.autrev.2019.05.006

Cited by 45 publications

(34 citation statements)

References 209 publications

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“…Besides vaccine antigens, which could cause (due to the molecular mimicry phenomenon) the development of AAb targeting the central nervous system, the second component of HPV vaccines—aluminum adjuvants—could also induce a neuroinflammatory background in patients who develop adverse events following HPV vaccination. Signs of an inflammatory process in the CNS and the toxicity of Al adjuvant/Al-containing vaccines has been reported in different countries and in both mouse and large animal (sheep) models [110]. As was shown, Al particles are able to disseminate from the injection site within immune cells to the lymph nodes and to the brain, from which they do not recirculate [111].…”

Section: Human Papillomavirus Vaccination and Fmmentioning

confidence: 99%

Neuroimmunology: What Role for Autoimmunity, Neuroinflammation, and Small Fiber Neuropathy in Fibromyalgia, Chronic Fatigue Syndrome, and Adverse Events after Human Papillomavirus Vaccination?

Ryabkova

Чурилов

Shoenfeld

2019

IJMS

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Fibromyalgia is a disorder characterized by chronic widespread pain and non-pain symptoms, such as fatigue, dysautonomia, and cognitive and sleep disturbances. Its pathogenesis and treatment continue to be the subject of debate. We highlight the role of three mechanisms—autoimmunity, neuroinflammation, and small fiber neuropathy—in the pathogenesis of the disease. These mechanisms are shown to be closely interlinked (also on a molecular level), and the review considers the implementation of this relationship in the search for therapeutic options. We also pay attention to chronic fatigue syndrome, which overlaps with fibromyalgia, and propose a concept of “autoimmune hypothalamopathy” for its pathogenesis. Finally, we analyze the molecular mechanisms underlying the neuroinflammatory background in the development of adverse events following HPV vaccination and suggesting neuroinflammation, which could exacerbate the development of symptoms following HPV vaccination (though this is hotly debated), as a model for fibromyalgia pathogenesis.

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Section: Human Papillomavirus Vaccination and Fmmentioning

confidence: 99%

Neuroimmunology: What Role for Autoimmunity, Neuroinflammation, and Small Fiber Neuropathy in Fibromyalgia, Chronic Fatigue Syndrome, and Adverse Events after Human Papillomavirus Vaccination?

Ryabkova

Чурилов

Shoenfeld

2019

IJMS

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“…Other conditions have been associated with adjuvants, as assessed by a recent review of patients with myalgic encephalomyelitis/chronic fatigue syndrome in France, supporting the view that this recognized condition may be, at least in a percentage of cases, a result of adverse effects of vaccines containing poorly degradable particulate aluminium adjuvants [7].…”

Section: Discussionmentioning

confidence: 92%

Macrophagic myofasciitis: an atypical presentation for a rare disease with a challenging approach

Dias¹,

Faria²,

Ribeiro³

et al. 2020

Reumatologia

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Macrophagic myofasciitis (MMF) is a rare immune-mediated myopathy that seems to be triggered by aluminium hydroxide adjuvant used in vaccines. Its presentation is relatively heterogeneous and treatment with steroids leads to improvement, although there is little evidence regarding the role of other immunosuppressants. The histological findings in MMF seem to be the result of an abnormal presence in the inoculation site of aluminium, which can induce an immune-mediated muscular disease in susceptible persons. The authors describe the case of a patient with an atypical presentation of macrophagic myofasciitis, with histological confirmation in a muscle biopsy distant from the inoculation site, and a good therapeutic response to tacrolimus and mycophenolate mofetil, as well as a discussion on the pathologic basis, controversies and emerging treatments for this condition.

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“…Astrocytes on the other hand would be protected by the blood brain barrier. However, it has been proposed that aluminum in vaccines may persist in cells of the immune system (such as macrophages) and that these cells can travel to distal sites such as the brain J o u r n a l P r e -p r o o f and indirectly impact these tissues (Gherardi et al, 2019). Astrocytes are immunecompetent resident brain cells that play an important role in homeostatic regulation of the brain.…”

Section: Introductionmentioning

confidence: 99%

Distinctive cellular response to aluminum based adjuvants

Nies

Hidalgo

Bondy

et al. 2020

Environmental Toxicology and Pharmacology

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Myalgia and chronic fatigue syndrome following immunization: macrophagic myofasciitis and animal studies support linkage to aluminum adjuvant persistency and diffusion in the immune system

Cited by 45 publications

References 209 publications

Neuroimmunology: What Role for Autoimmunity, Neuroinflammation, and Small Fiber Neuropathy in Fibromyalgia, Chronic Fatigue Syndrome, and Adverse Events after Human Papillomavirus Vaccination?

Neuroimmunology: What Role for Autoimmunity, Neuroinflammation, and Small Fiber Neuropathy in Fibromyalgia, Chronic Fatigue Syndrome, and Adverse Events after Human Papillomavirus Vaccination?

Macrophagic myofasciitis: an atypical presentation for a rare disease with a challenging approach

Distinctive cellular response to aluminum based adjuvants

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