MWCNT–CTAB modified glassy carbon electrode as a sensor for the determination of paracetamol

Abstract

An electrochemical sensor for sensitive detection of paracetamol (PCM) was developed by constructing the glassy carbon electrode (GCE) modified with multiwalled carbon nanotubecetyltrimethyl ammonium bromide (MWCNT-CTAB). Modification improves the redox kinetics of PCM with increased current intensity. A similar modification at CTAB modified GCE did not result in an impressive charge transfer. Detection limit of PCM was determined from differential pulse voltammetric (DPV) study and found to be 4.82×10 −9 M with a linear dynamic range of 4.0×10 −7 M to 4.0×10 −6 M. The interference studies showed that the modified electrode exhibits excellent selectivity in the presence of large excess of interferents and response is fast, stable, reliable, resistant to biofouling and can be applied for the real sample analysis in medical, pharmaceutical and biotechnological sectors.Kinetic parameters were determined using electrochemical approaches. The practical analytical application of this electrode was demonstrated by measurement of PCM content in PYREMOL 650 tablet and real sample analysis.

Experimental and computational studies of the interactions between carbon nanotubes and ionic liquids used for detection of acetaminophen

“…Because a linear correlation was obtained between the peak current and the scan rate, we conclude that the redox process is controlled by adsorption rather than the diffusion of ACOP on the electrode surface. This result is in agreement with previous literature reports [45][46][47][48][49].…”

Multiwalled carbon nanotubes decorated with bismuth (III) oxide for electrochemical detection of an antipyretic and analgesic drug paracetamol in biological samples

“…The aforementioned methods are sensitive and reliable. Conversely, they are expensive instrumental techniques that require substantial times for sample pretreatment and require qualified and experienced technicians making them unsuitable for routine analysis (Gowda et al 2015). In recent years, electrochemical methods have proven to be good since they offer the opportunities like portability, sensitivity, less expenses, reproducibility, and rapid methodologies (Gupta et al 2006;Moyo et al 2015;Bouabi et al 2016).…”

“…The modification has also been applied in an attempt to reduce poor voltammetric responses caused by sluggish electrode kinetics and electrode fouling encountered at bare electrode which decrease sensitivity and reproducibility (Bouabi et al 2016). Modifiers such as multiwalled carbon nanotube-cetyltrimethyl ammonium (Gowda et al 2015), chitosan (Bouabi et al 2016), graphene (Kang et al 2010), carbon nano-tube composite film (Li et al 2006), magnesium diboride microparticles (Zidan et al 2011a(Zidan et al , 2011b, nafion/TiO 2 -graphene (Fan et al 2011), bismuth oxide nanoparticles (Zidan et al 2011a(Zidan et al , 2011b, nickel and nickel-copper alloy (Feizbakhsh et al 2012), graphene oxide (Zidan et al 2014), multiwalled carbon nanotubes and dopamine nanospheres functionalized with gold nanoparticles (Liu et al 2014), nickel oxide nanoparticles and carbon black (Deroco et al 2014), cuprous oxide nanoparticles-graphene (Yang et al 2015), graphene (Fernandez et al 2015), single-walled carbon nanotube/ nickel nanocomposite (Ngai et al 2015), cadmium selenide microspheres (Yin et al 2012), and poly(glycine) (Kuskur et al 2015) have offered great success for the decrease in overpotential and increase of sensitivity during oxidation of paracetamol. Even though the aforementioned modifiers have proved to be effective, a search for new combinations should still continue so that better sensitivity, selectivity, and good stability are achieved during electrochemical detection.…”

Voltammetric Behaviors and Determination of Thiocyanate on Multiwalled Carbon Nanotubes‐Cetyltrimethylammonium Bromide Modified Electrode

“…It can not only help disperse CNTs in aqueous solution to fabricate CNTs‐modified electrode , but also further increase the response of analyte on CNTs‐modified electrode . Electrochemical sensors based on CNTs‐CTAB modified electrodes for determination of 4‐aminoantipyrine , paracetamol , tripelennamine hydrochloride and flavonoids have been described.…”