Mutual suppression of cardiovascular effects of some β-adrenoreceptor agonists in the cat

Atkinson, Judith M.; Rand, M. J.

doi:10.1111/j.2042-7158.1968.tb09674.x

Cited by 15 publications

(7 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Kingsley et al (1972) were unable to demonstrate tachyphylaxis to the acute heart rate effects of isoprenaline in normal human subjects. Atkinson & Rand (1968) observed decreased heart rate effects to injected isoprenaline (as well as to other catecholamines) given -during an isoprenaline--infusion in cats ( Figure 5 of their paper). The heait-rate response to injected isoprenaline was also decreased when it was injected during orciprenaline infusion ( Figure 6 of their paper).…”

Section: Discussionmentioning

confidence: 90%

“…Kingsley, Littlejohns & Prichard (1972) also studied heart rate increases in normal subjects to isoprenaline and concluded that there was no tachyphylaxis in terms of the dose required to produce a given peak heart rate. Tachyphylaxis to heart rate effects of isoprenaline has also been reported in dogs (Conolly et al, 1971) and cats (Atkinson & Rand, 1968).…”

Section: Introductionmentioning

confidence: 83%

See 1 more Smart Citation

Lack of Cardiac or Bronchodilator Tachyphylaxis to Isoprenaline in the Dog

Minatoya

Spilker

1975

British J Pharmacology

View full text Add to dashboard Cite

Tachyphylaxis to heart rate and bronchodilator effects of (±)‐isoprenaline was studied in anaesthetized open‐chest dogs by 5 procedures. Heart rate responses to a series of intravenous injections of isoprenaline were essentially unchanged before and after a 15 min infusion of isoprenaline (at 3 doses). Heart rate and bronchodilator responses in the same animal to an intravenous injection of isoprenaline were not significantly different before and after a 30 min infusion of isoprenaline (at 2 doses). Heart rate responses were relatively constant to an isoprenaline injection given every 30 min during a 4 h infusion of isoprenaline (at 3 doses), but the magnitude of the response was smallest for the largest infusion dose (highest background heart rate) and greatest for the smallest infusion dose (lowest background heart rate). Heart rate and bronchodilator responses in the same animal to isoprenaline were relatively constant during a 5 h infusion of isoprenaline (at 2 doses). Bronchodilator responses to intratracheally administered isoprenaline aerosol were essentially unchanged during a 4–5 h period using various doses and procedures. Tachyphylaxis to the heart rate or bronchodilator effects of isoprenaline was not observed. The present data give no support to the hypothesis that tachyphylaxis to isoprenaline aerosols is an important mechanism in asthma mortality.

show abstract

Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 83%

Lack of Cardiac or Bronchodilator Tachyphylaxis to Isoprenaline in the Dog

Minatoya

Spilker

1975

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…This was confirmed by Bouhuys, Douglas & Lewis (1972), but not by Pun, McCulloch & Rand (1971). Tolerance to the chronotropic actions of isoprenaline has also been reported as occurring in man and dogs (Conolly et al, 1971) and in cats (Atkinson & Rand, 1968). More recently, however, Minatoya & Spilker (1975) did not observe tolerance to the chronotropic or bronchodilator actions of isoprenaline in in vivo experiments on healthy dogs.…”

Section: Introductionmentioning

confidence: 82%

Investigation of Occurrence of Tolerance to Bronchodilator Drugs in Chronically Pretreated Guinea‐pigs

Anderson

Lees

1976

British J Pharmacology

View full text Add to dashboard Cite

I The actions of sympathomimetic amines on isolated preparations of atria, trachea and ileum were studied in vitro in guinea-pigs, which had been pretreated for 5 or 12 days, by subcutaneous injection, with adrenaline (5 jg/kg), salbutamol (0.5 gg/kg), methoxamine (250 gig/kg) or saline (0.9% w/v NaCl solution). 2 In the trachea, a decrease in sensitivity (tolerance) to the relaxant effect of adrenaline was induced by pretreatment, for 12 but not for 5 days, with adrenaline. In these animals, cross-tolerance to isoprenaline or salbutamol was not observed. Tolerance to the relaxant actions of adrenaline, isoprenaline or salbutamol was not observed after pretreatment with salbutamol. 3 In the trachea, pretreatment with methoxamine or adrenaline for 12 days did not change the sensitivity to the a-adrenoceptor-mediated contractor action of methoxamine. 4 In the atria from those guinea-pigs pretreated with adrenaline or salbutamol, there was no reduced sensitivity to the P-adrenoceptor agonist actions of adrenaline, isoprenaline or salbutamol. In animals pretreated with methoxamine or adrenaline, there was no observable tolerance or cross tolerance to methoxamine with respect to its a-adrenoceptor-mediated positive inotropic action in the atria and no unequivocal evidence of a reduced sensitivity to that action of adrenaline. 5It was confirmed that the twitch-like contractions of the longitudinal muscle of the electrically stimulated ileum were inhibited by sympathomimetic amines acting on a-and /i-adrenoceptors. There was no reduced sensitivity to the inhibitory actions of noradrenaline or isoprenaline on the twitch of ileum isolated from animals pretreated with adrenaline, salbutamol or methoxamine for 5 or 12 days. 6 From our results on these three preparations from the same animals, it is concluded that generalizations regarding changes in sensitivity to sympathomimetic amines following their prolonged administration should not be made in any one species.

show abstract

“…In these patients a normal bronchodilator response was followed by severe bronchoconstriction. A suggested mechanism is that following a period of ,B stimulation the , adrenoceptors become refractory to stimulation and thus unresponsive to endogenous and exogenous sympathetic stimulation (Atkinson & Rand, 1968;Conolly, Davies, Dollery & George, 1971). In normal human subjects the dose of isoprenaline by bolus injection to produce tachycardia was increased following an i.v.…”

Section: Discussionmentioning

confidence: 99%

Intravenous infusion of salbutamol in the treatment of asthma.

Spiro¹,

Johnson²

1975

Brit J Clinical Pharma

View full text Add to dashboard Cite

The effects of i.v. infusion of increasing rates of salbutamol for up to 4 h were documented in ten convalescent asthmatic patients. 2 The major bronchodilator effect was seen at 4.16 mug/minute. A small further improvement occurred at infusion rates up to 25.0 mug/min but was not significantly better than that seen at the lower infusion rate. 3 Cardiovascular effects were minimal after 60 min at the lower rate and even at 25.0 mug/min mean heart rate rose by only 17.1 beats/minute. All patients tolerated the 4 h infusion well. 4 It is concluded that i.v. infusion of salbutamol may be a useful addition to the treatment of the patient with a severe attack of asthma.

show abstract

Mutual suppression of cardiovascular effects of some β-adrenoreceptor agonists in the cat

Cited by 15 publications

References 9 publications

Lack of Cardiac or Bronchodilator Tachyphylaxis to Isoprenaline in the Dog

Lack of Cardiac or Bronchodilator Tachyphylaxis to Isoprenaline in the Dog

Investigation of Occurrence of Tolerance to Bronchodilator Drugs in Chronically Pretreated Guinea‐pigs

Intravenous infusion of salbutamol in the treatment of asthma.

Contact Info

Product

Resources

About