Mutual promotion of oxidative stress amplification and calcium overload by degradable spatially selective self-cascade catalyst for synergistic tumor therapy

Wang, Xiang; Li, Chunlin; Jin, Hongbin; Wang, Xianyou; Ding, Cheng; Cao, Dongmiao; Zhao, Linjing; Deng, Guoying; Lü, Jie; Wan, Zhang; Liu, Xijian

doi:10.1016/j.cej.2021.134438

Cited by 26 publications

(19 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…46 In addition, high valence ions such as Fe 3+ and Cu 2+ can scavenge intracellular ROS, 51,230,231 further amplifying oxidative stress and damage. 232 In the context of CDT, metal peroxide (CuO 2 , 56,230,233 CaO 2 , 234–236 etc .) NPs have been developed to self-supply H 2 O 2 .…”

Section: Ros Upregulation-potentiated/synergized Cancer Therapymentioning

confidence: 99%

Reactive oxygen species-upregulating nanomedicines towards enhanced cancer therapy

et al. 2023

View full text Add to dashboard Cite

show abstract

Section: Ros Upregulation-potentiated/synergized Cancer Therapymentioning

confidence: 99%

Reactive oxygen species-upregulating nanomedicines towards enhanced cancer therapy

et al. 2023

View full text Add to dashboard Cite

show abstract

“…An oxidatively stressed environment will alter the protein functions and prevent the proper relay of the calcium signal in CAT-downregulated cancerous cells, resulting in unrestrained Ca 2+ build-up and cell death [167,168]. Similarly, nanosystems which used CaO 2 as an oxygen source and hematoporphyrin monomethyl as a photosensitizer have been synthesized and reported [169,170].…”

Section: Targeting Metal Ion Homeostasismentioning

confidence: 99%

Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

Mbugua

2022

Bioinorganic Chemistry and Applications

View full text Add to dashboard Cite

Solid tumors have a unique tumor microenvironment (TME), which includes hypoxia, low acidity, and high hydrogen peroxide and glutathione (GSH) levels, among others. These unique factors, which offer favourable microenvironments and nourishment for tumor development and spread, also serve as a gateway for specific and successful cancer therapies. A good example is metal peroxide structures which have been synthesized and utilized to enhance oxygen supply and they have shown great promise in the alleviation of hypoxia. In a hypoxic environment, certain oxygen-dependent treatments such as photodynamic therapy and radiotherapy fail to respond and therefore modulating the hypoxic tumor microenvironment has been found to enhance the antitumor impact of certain drugs. Under acidic environments, the hydrogen peroxide produced by the reaction of metal peroxides with water not only induces oxidative stress but also produces additional oxygen. This is achieved since hydrogen peroxide acts as a reactive substrate for molecules such as catalyse enzymes, alleviating tumor hypoxia observed in the tumor microenvironment. Metal ions released in the process can also offer distinct bioactivity in their own right. Metal peroxides used in anticancer therapy are a rapidly evolving field, and there is good evidence that they are a good option for regulating the tumor microenvironment in cancer therapy. In this regard, the synthesis and mechanisms behind the successful application of metal peroxides to specifically target the tumor microenvironment are highlighted in this review. Various characteristics of TME such as angiogenesis, inflammation, hypoxia, acidity levels, and metal ion homeostasis are addressed in this regard, together with certain forms of synergistic combination treatments.

show abstract

“…[16] In particular, US stimulation can be accurately exposed to the designated target to significantly inhibit the expression of P-glycoprotein (P-gp) and promote accumulation of chemotherapeutic drugs in tumor cells. [17] However, SDT is similar to other ROS-mediated tumor therapies, such as chemodynamic therapy (CDT), [18][19][20][21] photodynamic therapy (PDT), [22,23] RT, [24] and chemotherapy, [25][26][27] which is limited by the hypoxic condition in tumors and cellular self-protective mechanisms. [28] The oxygen plays a vital role in ensuring ROS-induced cellular damage.…”

Section: Introductionmentioning

confidence: 99%

Intracellular Mutual Amplification of Oxidative Stress and Inhibition Multidrug Resistance for Enhanced Sonodynamic/Chemodynamic/Chemo Therapy

Guan¹,

Liu²,

et al. 2022

Small

Self Cite

View full text Add to dashboard Cite

Emerging noninvasive treatments, such as sonodynamic therapy (SDT) and chemodynamic therapy (CDT), have developed as promising alternatives or supplements to traditional chemotherapy. However, their therapeutic effects are limited by the hypoxic environment of tumors. Here, a biodegradable nanocomposite-mesoporous zeolitic-imidazolateframework@MnO 2 /doxorubicin hydrochloride (mZMD) is developed, which achieves enhanced SDT/CDT/chemotherapy through promoting oxidative stress and overcoming the multidrug resistance. The mZMD decomposes under both ultrasound (US) irradiation and specific reactions in the tumor microenvironment (TME). The mZM composite structure reduces the recombination rate of e − and h + to improve SDT. MnO 2 not only oxidizes glutathione in tumor cells to enhance oxidative stress, but also converts the endogenic H 2 O 2 into O 2 to improve the hypoxic TME, which enhances the effects of chemotherapy/SDT. Meanwhile, the generated Mn 2+ catalyzes the endogenic H 2 O 2 into •OH for CDT, and acts as magnetic resonance imaging agent to guide therapy. In addition, dissociated Zn 2+ further breaks the redox balance of TME, and co-inhibits the expression of P-glycoprotein (P-gp) with generated ROS to overcome drug resistance. Thus, the as-prepared intelligent biodegradable mZMD provides an innovative strategy to enhance SDT/CDT/chemotherapy.

show abstract

Mutual promotion of oxidative stress amplification and calcium overload by degradable spatially selective self-cascade catalyst for synergistic tumor therapy

Cited by 26 publications

References 70 publications

Reactive oxygen species-upregulating nanomedicines towards enhanced cancer therapy

Reactive oxygen species-upregulating nanomedicines towards enhanced cancer therapy

Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

Intracellular Mutual Amplification of Oxidative Stress and Inhibition Multidrug Resistance for Enhanced Sonodynamic/Chemodynamic/Chemo Therapy

Contact Info

Product

Resources

About