Mutual inhibition between YAP and SRSF1 maintains long non-coding RNA, Malat1-induced tumourigenesis in liver cancer

Wang, Jiayi; Wang, Hongmei; Zhang, Yue; Zhen, Ni; Zhang, Li; Qiao, Yongxia; Weng, Wenhao; Liu, Xiangfan; Ma, Lifang; Xiao, Wenlei; Yu, Wenjun; Chu, Qinghua; Pan, Qiuhui; Sun, Fenyong

doi:10.1016/j.cellsig.2014.01.022

Cited by 93 publications

(93 citation statements)

References 46 publications

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“…Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a highly conserved and widely expressed lncRNA that is over 8 kb in length [9], and regulates proliferation as well as metastasis in many cancers [10,11]. Recently, some studies have reported a new regulatory model in which lncRNA can act as a competing endogenous RNA (ceRNA) and crosstalk with mRNAs by competitively binding their common miRNAs [12].…”

Section: Ping Linmentioning

confidence: 99%

Long Non-Coding MALAT1 Functions as a Competing Endogenous RNA to Regulate Vimentin Expression by Sponging miR-30a-5p in Hepatocellular Carcinoma

Pan

Tong

Cui

et al. 2018

Cell Physiol Biochem

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Background/Aims: Hepatocellular carcinoma (HCC) has a high morbidity as well as mortality and is believed to be one of the most prevalent cancers worldwide. The long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is involved in numerous cancers, including HCC. This study aimed to explore the role of MALAT1 in HCC progression. Methods: The expression levels of MALAT1 and Vimentin in HCC tissues and relative pair-matched adjacent normal liver tissues were analyzed by RT-PCR, and immunohistochemistry. Using bioinformatics analysis and dual-luciferase assay, we examined the correlation between MALAT1 and miR-30a-5p. Dual-luciferase assay and western blotting suggested that Vimentin was a target of miR-30a-5p. A wound healing assay and transwell assays were employed to determine the effect of MALAT1 and miR-30a-5p on cell migration and invasion in HCC. Results: Our data demonstrated that the levels of MALAT1 and Vimentin were upregulated in HCC tissues and that miR-30a-5p was a direct target of MALAT1. Silenced MALAT1 and overexpressed miR-30a-5p each inhibited cell migration and invasion. Additionally, dual-luciferase assay and western blotting demonstrated that MALAT1 could competitively sponge miR-30a-5p and thereby regulate Vimentin. Conclusion: Our data suggest that MALAT1 acts as an oncogenic lncRNA that promotes HCC migration and invasion. Therefore, the MALAT1-miR-30a-5p-Vimentin axis is a potential therapeutic target and molecular biomarker in HCC.

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Section: Ping Linmentioning

confidence: 99%

Long Non-Coding MALAT1 Functions as a Competing Endogenous RNA to Regulate Vimentin Expression by Sponging miR-30a-5p in Hepatocellular Carcinoma

Pan

Tong

Cui

et al. 2018

Cell Physiol Biochem

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“…The altered ASOs effectively reduced MALAT-1 expression compared with the control ASO (38). A study conducted by Wang et al indicated an interaction between the Yes-associated protein (YAP) and SRSF1 by Angiomotin regulated MALAT-1 (19). The MALAT-1-mediated tumorigenesis in HCC provided a novel mechanism for YAP regulation of gene expression at (Fig.…”

Section: Molecular Targets Of Malat-1mentioning

confidence: 99%

“…Numerous studies have assessed the biology of MALAT-1 in cancer (15)(16)(17)(18)(19)(20)(21)(22). The role of MALAT-1 in cellular transformation suggests that MALAT-1 has the potential to function as a biomarker and a target for novel therapeutic approaches in multiple myeloma (MM).…”

Section: Potential Clinical Applications Of Malat-1mentioning

confidence: 99%

“…For example, MALAT-1 was detected in the cerebellum of human alcoholics (14). However, MALAT-1 is a typical multifunctional gene that is important in a wide array of cancers, including bladder cancer (15,16), gallbladder carcinoma (GBC) (17,18), hepatocellular carcinoma (HCC) (19) and lung (20,21) and gastric cancer (GC) (22). Therefore, understanding the regulation function of MALAT-1 within the context of cancer is of considerable significance.…”

Section: Introductionmentioning

confidence: 99%

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Novel insight into MALAT-1 in cancer: Therapeutic targets and clinical applications

Ren

et al. 2016

Oncology Letters

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Abstract. Long non-protein-coding RNAs (lncRNAs) are emerging as important gene expression regulators that are linked to various biological processes at the post-transcriptional and transcriptional levels. lncRNAs are known to be important in cell proliferation, cell differentiation, apoptosis and metastasis. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1), a novel lncRNA, is highly conserved amongst mammals. In addition, it has been considered to act as an oncogene, depending on the tumor system. An increasing number of studies have indicated that MALAT-1 may be detected in certain types of human tumors, including lung and bladder cancer and hepatocellular carcinoma. MALAT-1 silencing may be an effective therapeutic approach against tumors. The present study reviews the current knowledge on the functional role of MALAT-1 in the control of various cancers.

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“…Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a critical regulator of maintaining the transformative phenotype in HCC, it associates with tumor metastasis and recurrence [102] . MALAT1 is a genuine target gene of the Wnt/TCF/β-catenin and Hippo/yes associated protein (YAP) signaling pathway.…”

Section: Metastasis-associated Lung Adenocarcinoma Transcriptmentioning

confidence: 99%

Long noncoding RNAs in hepatocellular carcinoma: Novel insights into their mechanism

Liu

Tang

Huang

et al. 2015

WJH

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Hepatocellular carcinoma (HCC) is the predominant subject of liver malignancies which arouse global concern. Advanced studies have found that long noncoding RNAs (lncRNAs) are differentially expressed in HCC and implicate they may play distinct roles in the pathogenesis and metastasis of HCC. However, the underlying mechanisms remain largely unclear. In this review, we summarized the functions and mechanisms of those known aberrantly expressed lncRNAs identified in human HCC tissues. We hope to enlighten more comprehensive researches on the detailed mechanisms of lncRNAs and their application in clinic, such as being used as diagnostic and prognostic biomarkers and the targets for potential therapy. Although studies on lncRNAs in HCC are still deficient, an improved understanding of the roles played by lncRNAs in HCC will lead to a much more effective utilization of those lncRNAs as novel candidates in early detection, diagnosis, prevention and treatment of HCC.

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Mutual inhibition between YAP and SRSF1 maintains long non-coding RNA, Malat1-induced tumourigenesis in liver cancer

Cited by 93 publications

References 46 publications

Long Non-Coding MALAT1 Functions as a Competing Endogenous RNA to Regulate Vimentin Expression by Sponging miR-30a-5p in Hepatocellular Carcinoma

Long Non-Coding MALAT1 Functions as a Competing Endogenous RNA to Regulate Vimentin Expression by Sponging miR-30a-5p in Hepatocellular Carcinoma

Novel insight into MALAT-1 in cancer: Therapeutic targets and clinical applications

Long noncoding RNAs in hepatocellular carcinoma: Novel insights into their mechanism

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