Mutual exclusion of t(11;18)(q21;q21) and numerical chromosomal aberrations in the development of different types of primary gastric lymphomas

Schreuder, Max I.; Hoeve, Marieke A.; Hebeda, Konnie M.; Verdijk, Marian A. J.; Ligtenberg, Marjolijn J. L.; Bot, Fredrik J.; Chott, Andreas; Krieken, J. Han J.M. van

doi:10.1046/j.1365-2141.2003.04630.x

Cited by 23 publications

(43 citation statements)

References 44 publications

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“…[21][22][23][24][25] In the largest series of 138 cases reported to date, Ye et al 20 detected the API2-MALT1 fusion transcript at exactly the same 23.9% as in our study. The detection of the t(11;18)(q21;q21) in gastric MALT lymphoma is clinically important as most translocation-positive tumors do not respond to H. pylori eradication therapy, are associated with more advanced stage of disease, and usually do not transform into aggressive lymphoma.…”

Section: Discussionsupporting

confidence: 55%

Variable frequencies of MALT lymphoma-associated genetic aberrations in MALT lymphomas of different sites

et al. 2004

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Although several recurrent genetic aberrations are known to occur in MALT lymphoma, no comprehensive study on the most prevalent MALT lymphoma-associated genetic aberrations is available. We therefore screened 252 primary MALT lymphomas for translocations t(11;18)(q21;q21), t(14;18) (q32;q21), and t(1;14)(p22;q32), and trisomies 3 and 18. The above-listed translocations occurred mutually exclusively and were detected overall in 13.5, 10.8, and 1.6% of the cases; trisomy 3 and/or 18 occurred in 42.1%. The frequency at which the translocations occurred varied markedly with the primary site of disease. The t(11;18)(q21;q21) was mainly detected in pulmonary and gastric tumors, whereas the t(14;18)(q32;q21) was most commonly found in lesions of the ocular adnexa/ orbit, skin, and salivary glands. Trisomies 3 and 18 each occurred most frequently in intestinal and salivary gland MALT lymphomas. Our results demonstrate that the three translocations and trisomies 3 and 18 occur at markedly variable frequencies in MALT lymphoma of different sites.

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Section: Discussionsupporting

confidence: 55%

Variable frequencies of MALT lymphoma-associated genetic aberrations in MALT lymphomas of different sites

et al. 2004

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“…These lymphomas may develop either de novo or by transformation out of a prior low-grade MZBCL. [48][49][50][51] Systemic lupus erythematosus patients were reported to have 8-fold and 3-fold higher incidences of, respectively, MZBCL and DLBCL as well. 48,52 Rheumatoid arthritis (RA) appears to be weakly associated with non-RA treatment related, development of DLBCL and lympho-plasmacytic lymphoma, with reported odd ratios of 1.8 and 2.5, respectively.…”

Section: Auto-immune Inflammatory Conditions Associated With B-cell Lmentioning

confidence: 99%

Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas

Bende¹,

Maldegem²,

Noesel³

2009

Haematologica

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Chronic autoimmune or pathogen-induced immune reactions resulting in lymphoid neogenesis are associated with development of malignant lymphomas, mostly extranodal marginal zone B-cell lymphomas (MZBCLs). In this review we address (i) chemokines and adhesion molecules involved in lymphoid neogenesis; (ii) the autoimmune diseases and pathogens which are associated with development of B-cell lymphomas; (iii) the molecular mechanisms involved in the initiation and progression of MZBCL; and (iv) 'potential' mouse models for MZBCL.Key words: B-cell non-Hodgkin's lymphoma, extranodal marginal zone B-cell lymphoma, immunoglobulin, B-cell antigen receptor, inflammation, lymphoid tissue neogenesis. Haematologica 2009;94:1109-1123. doi:10.3324/haematol.2009 This is an open-access paper. Citation: Bende RJ, van Maldegem F, and van Noesel CJM. Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B cell lymphomas. ABSTRACT Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas

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“…Nuclei were isolated from the paraffin-embedded tissues as described previously. 17 Briefly, 50-mm thick sections were dewaxed by xylene, disaggregated manually and digested with 0.1% protease in phosphate-buffered saline for 40 min at 371C. To make the target DNA accessible to the probes, the nuclear suspension was spun onto slides and subsequently incubated in a solution of 1 mol/l NaSCN at 801C for 30 min and in 0.1% pepsin (Sigma-Aldrich), pH 2.0 at 371C for 5-30 min.…”

Section: Fluorescence In Situ Hybridization (Fish) Analysismentioning

confidence: 99%

“…12 Four mutually exclusive and apparently sitespecific, chromosomal translocations have been implicated in the development and progression of extranodal marginal zone lymphoma of mucosaassociated lymphoid tissue. These extranodal marginal zone lymphoma-associated translocations, t(11;18)(q21;q21), 11,[13][14][15][16][17][18][19][20][21][22] t(1;14)(p22;q32), 13,14,23 t(14;18) (q32;q21) 14,15,24,25 and t(3;14)(p14.1;q32) 26 show substantial differences in prevalence at specific extranodal localizations. In addition, several studies have reported the presence of various cytogenetic numerical aberrations, including trisomy 3, 7, 12 and 18, in extranodal marginal zone lymphoma at different extranodal sites.…”

mentioning

confidence: 99%

“…In addition, several studies have reported the presence of various cytogenetic numerical aberrations, including trisomy 3, 7, 12 and 18, in extranodal marginal zone lymphoma at different extranodal sites. 8,15,17,[27][28][29][30][31][32][33][34][35] One may wonder whether these extranodal marginal zone lymphoma-associated translocations and numerical aberrations occur in extranodal diffuse large B-cell lymphoma with marginal zone lymphoma components, which may belong to the extranodal marginal zone lymphoma spectrum.…”

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confidence: 99%

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T(14;18)(q32;q21) involving MALT1 and IGH genes occurs in extranodal diffuse large B-cell lymphomas of the breast and testis

et al. 2013

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Primary B-cell lymphoma of the testis, breast and thyroid are rare and data concerning cytogenetic aberrations at these extranodal sites are scarce. We examined the presence of extranodal marginal zone lymphomaassociated translocations, t(11;18)(q21;q21), t(1;14)(p22;q32), t(14;18)(q32;q21), t(3;14)(p14.1;q32) and numerical aberrations of chromosomes 1, 3, 12 and 18 by fluorescence in situ hybridization in 6 extranodal marginal zone lymphomas and 24 diffuse large B-cell lymphomas with (n ¼ 9) or without (n ¼ 15) marginal zone lymphoma components, with primary localizations in the breast (n ¼ 15), testis (n ¼ 9) and thyroid (n ¼ 6). We found t(14;18)(q32;q21), with breakpoints in IGH and MALT1, in one testicular diffuse large B-cell lymphoma and in two diffuse large B-cell lymphomas of the breast. No other translocations, amplifications or deletions involving IGH, BCL-10, BCL-2, MALT1 and IAP2 were detected. Numerical aberrations occurred in 67% of the lymphomas, 67% of extranodal marginal zone lymphomas, 56% of diffuse large B-cell lymphomas with marginal zone lymphoma components and in 73% of 'de novo' diffuse large B-cell lymphomas. These included 78% of testis, 67% of thyroid and 60% of breast lymphomas, and included mainly trisomy 18 (n ¼ 16), trisomy 3 (n ¼ 8) and trisomy 1 (n ¼ 3). One testicular diffuse large B-cell lymphoma harbored both t(14;18)(q32;q21) and trisomy 3. Our results indicate that at least a few cases of diffuse large B-cell lymphoma of the testis and the breast belong to the spectrum of extranodal marginal zone lymphoma. Modern Pathology (2013) 26, 421-427; doi:10.1038/modpathol.2012; published online 28 September 2012Keywords: B-cell lymphoma; FISH; IGH; MALT1; numerical chromosomal aberrations; translocations Primary B-cell lymphoma of the testis, breast and thyroid are rare, each accounting for between 0.5 and 2.5% of all non-Hodgkin's lymphomas (NHLs). [1][2][3][4][5][6] Diffuse large B-cell lymphoma is the most common histological entity at these extranodal sites. Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue, commonly found in extranodal sites devoid of native lymphoid tissue, like the stomach, lung, salivary gland, thyroid and ocular adnexa, occur infrequently in the breast and testis. Although extranodal marginal zone lymphoma and diffuse large B-cell lymphoma are considered distinct clinicopathological entities in the World Health Organization (WHO) classification, 7 many extranodal diffuse large B-cell lymphomas have derived from a background of extranodal marginal zone lymphoma. [8][9][10][11] We found that a large subgroup of primary testicular diffuse large B-cell lymphoma has marginal zone lymphoma components, including small cell components and lymphoepithelial lesions. 12 Four mutually exclusive and apparently sitespecific, chromosomal translocations have been implicated in the development and progression of extranodal marginal zone lymphoma of mucosaassociated lymphoid tissue. These extranodal marginal zone lymphoma-associated translocations, t(11...

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Mutual exclusion of t(11;18)(q21;q21) and numerical chromosomal aberrations in the development of different types of primary gastric lymphomas

Cited by 23 publications

References 44 publications

Variable frequencies of MALT lymphoma-associated genetic aberrations in MALT lymphomas of different sites

Variable frequencies of MALT lymphoma-associated genetic aberrations in MALT lymphomas of different sites

Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas

T(14;18)(q32;q21) involving MALT1 and IGH genes occurs in extranodal diffuse large B-cell lymphomas of the breast and testis

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