Mutual Benefit between Cu(II) and Polydopamine for Improving Photothermal–Chemodynamic Therapy

Abstract

Combination therapy has attracted extensive interest in alleviating the shortcomings of monotherapy and enhancing the treatment efficacy. In this work, hollow mesoporous silica nanoparticles (HMSNs) play the role of nanocarriers in the delivery of Cu­(II)-doped polydopamine (PDA), termed as HMSNs@PDA-Cu, for synergistic therapy. PDA acts as a traditional photothermal agent to realize photothermal treatment (PTT). Chemodynamic therapy (CDT) is realized by the reaction of Cu­(II) with intracellular glutathione (GSH), and subsequently, the generated Cu­(I) reacts with H2O2 to produce toxic hydroxyl radical (•OH) through a Fenton-like reaction. The photothermal performance of PDA is improved after its coordination with Cu­(II). On the other hand, PDA exhibits superoxide dismutase (SOD)-mimicking activity. PDA converts O2 •– to H2O2 and improves the production of H2O2, which promotes the therapeutic effect of CDT. Moreover, the high temperature caused by PTT further enhances the yield of •OH for CDT. This nanotheranostic platform perfectly applied to the tumor depletion of mice, presenting great potential for cancer metastasis therapy in vitro and in vivo.

Ultrasound and laser-promoted dual-gas nano-generator for combined photothermal and immune tumor therapy

“…When either laser or ultrasound irradiation was applied, CPM-treated cells showed stronger fluorescence intensity ( Figure 3C ), suggesting that both laser irradiation and ultrasound promoted ROS production. This result may be caused by ultrasound-enhanced mitochondrial Ca 2+ overload and laser-promoted CDT ( Zhang et al, 2021 ). As anticipated, the CPM + US + L group showed the strongest green fluorescence compared to the CPM + US and CPM + L groups, suggesting the superiority of the combination therapy.…”

Flexible Recyclable Cellulose Paper Templated Cu‐Doped Polydopamine Membranes with Dual Enzyme‐Like Activity

“…[27] This further verified the formation of Schiff base between DAC and PDA. The highresolution scan XPS spectrum of Cu 2p (Figure 2e) displayed two Cu + characteristic peaks at 933.2 and 952.7 eV, [28,29] and other two peaks were associated with iodine (I) ion. The spectrum in electron paramagnetic resonance (EPR) also showed Cu + signals at 3353-3364 G (Figure 2f).…”

Rapid In Situ Deposition of Iron-Chelated Polydopamine Coating on the Polyacrylamide Hydrogel Dressings for Combined Photothermal and Chemodynamic Therapy of Skin Wound Infection

“…These results suggested that PAM hydrogel, NIR laser irradiation and 0.5 mM H 2 O 2 had no antibacterial effect, and the photothermal effect of 150 μg/mL PDA was not enough to achieve antibacterial ability. [43][44][45]55 Compared with the PDA− PAM + NIR group, the FePDA−PAM + NIR treatment showed an obvious PTT antibacterial property (29.9%) due to the stronger absorbance and photothermal heating ability of FePDA. In the presence of H 2 O 2 , the FePDA−PAM hydrogel possessed a relatively better antibacterial effect (40.7%), which might be attributed to the ROS produced from FePDA effectively sterilizing bacteria by damaging cellular membranes, proteins, and DNA.…”

“…Fortunately, many studies have been reported on the acceleration of DA polymerization by reactive oxygen species (ROS) generated by metal ions and hydrogen peroxide (H 2 O 2 ). , It is worth noting that these transition metal ions (e.g., Fe 3+ , Cd 2+ , Cu 2+ , Ag + , Mn 2+ , Ni 2+ , etc.) can be assembled into the network structure of PDA in the polymerization process by chelating with catechol and/or imine groups − and show the Fenton or Fenton-like activity for the conversion of exogenous and endogenous H 2 O 2 to the highly toxic hydroxyl radicals ( • OH), − which can cause severe oxidative damage for chemodynamic therapy (CDT) of wound bacterial infection . For examples, Zhou et al prepared a novel divalent ion cross-linking alginate polyacrylamide hydrogel, which showed a spectrum of antibacterial activity and the ability to accelerate wound closure .…”